Protein Alignment Rfx and RFX4

DIOPT Version :10

• Sequence 1: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: NP_001193620.1
• Gene: RFX4 / 5992
• HGNCID: 9985
• Length: 744
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 182/552 - (32%)
• Similarity: 266/552 - (48%)
• Gaps: 104/552 - (18%)

  Fly   323 ERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPDSDQSALGSSN 387
            :|...|...:...|::..  :.|:::      ...::|        |..|..|.|.::.   ..|
Human    13 DRTRPRRRRSTESWIERC--LNESEN------KRYSSH--------TSLGNVSNDENEE---KEN 58

  Fly   388 KIAS------ATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGL 446
            ..||      ||::||..|||.|:||.:|||.||.||:..|.::..:|||||||||:||..|..|
Human    59 NRASKPHSTPATLQWLEENYEIAEGVCIPRSALYMHYLDFCEKNDTQPVNAASFGKIIRQQFPQL 123

  Fly   447 RTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAG 511
            .||||||||.||||||||.:|.    :||..|                          |..|..|
Human   124 TTRRLGTRGQSKYHYYGIAVKE----SSQYYD--------------------------VMYSKKG 158

  Fly   512 QLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQY-----IGDGTSALPSFPPI-ELNHSFNSE 570
            ....|                 .|.|.|..:..:.|     :|   :.||.||.: :||  ..:.
Human   159 AAWVS-----------------ETGKKEVSKQTVAYSPRSKLG---TLLPEFPNVKDLN--LPAS 201

  Fly   571 LTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRASDNNNLDECEEEKYLSKTKLYLL 635
            |..|.|.||..:||.||:..||.|:...|:.|:..|..||:....:.|.               :
Human   202 LPEEKVSTFIMMYRTHCQRILDTVIRANFDEVQSFLLHFWQGMPPHMLP---------------V 251

  Fly   636 CHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQ 700
            ...:.|...|...|...|:....|::|.||:::|::|||.||.|||.|:.||..::..:||.|..
Human   252 LGSSTVVNIVGVCDSILYKAISGVLMPTVLQALPDSLTQVIRKFAKQLDEWLKVALHDLPENLRN 316

  Fly   701 IKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWVSQCA--- 762
            ||......|.|.|||.||||||.||:|.|:.:.....|||.|...||.:::.:|..:..:.:
Human   317 IKFELSRRFSQILRRQTSLNHLCQASRTVIHSADITFQMLEDWRNVDLNSITKQTLYTMEDSRDE 381

  Fly   763 -PAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGK--PTYARAARQFLLKWSFYSSM 824
             ..::.:|..:|...|::||.:|.:..||..:|:..:.:...|  .:..:.|:||||.||.:.:.
Human   382 HRKLITQLYQEFDHLLEEQSPIESYIEWLDTMVDRCVVKVAAKRQGSLKKVAQQFLLMWSCFGTR 446

  Fly   825 IIRDLTLRSASSFGSFHLIRLLFDEYMFYLVE 856
            :|||:||.||.||||||||.|:||:|:.||:|
Human   447 VIRDMTLHSAPSFGSFHLIHLMFDDYVLYLLE 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	47/75 (63%)
RFX4	NP_001193620.1	RFX_DNA_binding	67..145	CDD:460512	47/77 (61%)