Protein Alignment Rfx and Rfx1

DIOPT Version :10

• Sequence 1: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: XP_011246631.1
• Gene: Rfx1 / 19724
• MGIID: 105982
• Length: 1073
• Species: Mus musculus
• Alignment Length: 1027
• Identity: 365/1027 - (35%)
• Similarity: 497/1027 - (48%)
• Gaps: 228/1027 - (22%)

  Fly     7 PQRQFILSTRSAIVDATSPPEDSAEEQQQLTVEVESATNGVITNSTTSPPPHAEQFEFCT--EDG 69
            ||.|::...:|. ...|.||    ..|:|...|:.:|. .....:|.:|.|.|:|:...|  |..
Mouse    44 PQPQYVTELQSP-QPQTQPP----GSQKQYVAELPAAP-APSQPATPAPSPVAQQYIVVTVSEGA 102

  Fly    70 VVVSATLED-----------VMTQVKLFPLLQNCQLLQKKLVDEDDDSTGVGATDADQLEVISVV 123
            :..|.|:.:           |.|||     :|..|..|::|:.:.......|  ....|::.::.
Mouse   103 MRASETVSEASPSSTASQTGVPTQV-----VQQVQGTQQRLLVQASVQAKPG--HVSPLQLTNIQ 160

  Fly   124 LPMDA-------EDSTSDAHLHGHVV---------------------NSSSDTMGTITTTEPNGT 160
            :|..|       ..|.:.....|.|.                     ||:|.|.||...|
Mouse   161 VPQQAIPTQHLVVQSPAPGTKSGQVSLTVHSAQQVHSAPERSPVQANNSTSKTAGTPAAT----- 220

  Fly   161 TVTHSIPIHSMADLAAIKDGVDLAQQVANGQVTVVQTTEDDDGTPFITVTVSGQEQNYQVQYVDS 225
              ...:.:||      ::..|.:.|     :.:|||.|......|...:||.|.:..:..|....
Mouse   221 --VQQLQVHS------VQQSVPVTQ-----ERSVVQATPQTKAGPVQQLTVQGLQPVHVAQESSG 272

  Fly   226 ELYHSNSSQTQMTYPFCP--------------------VGDYQGNGQTAYYST------------ 258
            ..:.:..::.|.|.|..|                    :|..|   |..:|..
Mouse   273 SQFPARKAEQQETRPTPPPEPPPRPPGPGPVCCGEVLQLGSEQ---QPLHYEPGVEQWVELVGML 334

  Fly   259 -------------TGQYGTTSSAGGSSNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGRD 310
                         ..|.|.::.|        |..|...:.....:|:.|:|..:.|....    .
Mouse   335 PPHLLLPQQRVVFEPQRGLSARA--------SPDLRVRIHRMPQVLVFGTALKVQQLPQV----P 387

  Fly   311 SPHSLT-----VSSRDWERDADRVNGTNRHWVQEVAYIQEA-------------QSTPQT----- 352
            .||..:     |...|....|..:..:...:.:...|.|.|             .|||.|
Mouse   388 VPHVYSSQVQYVEGGDASYTASAIRSSTYQYPETPIYTQTAGTSYYEASGTAAQVSTPATSQTVA 452

  Fly   353 ---------------PTSTTTTHSASGGSLGTGG-------GGASPDSDQSALGS---------- 385
                           .:|:::...||..|:|.||       ||.|..|..|..|:
Mouse   453 SSGSVPMYVSGSPIVASSSSSEAGASNSSVGAGGNGGGGSSGGGSGGSSGSGAGTYVIQGGYMLG 517

  Fly   386 --------SNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSV 442
                    :.:.:.||::||..|||||:||||||||||.||:.||.|.|||||||||||||||||
Mouse   518 NASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSV 582

  Fly   443 FSGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTS 507
            |.|||||||||||||||||||:|||..|.| .:.|:|:|.:|....|.|..........|..|
Mouse   583 FMGLRTRRLGTRGNSKYHYYGLRIKASSPL-LRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGV-- 644

  Fly   508 STAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSFPPIELNHSFNSE-L 571
                    :||:..|   :.|.|....:.:.:.|:   |:: |.:.:||.|..::|......| :
Mouse   645 --------ANGVAVG---QQSTGLSDISAQVQQYQ---QFL-DASRSLPDFAELDLQGKVLPEGV 694

  Fly   572 TLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRASDNNNLDECEE----------EKY 626
            ...|:..|:.|||||||:.:|.::||:|..||.|.:.|||    .||.:..|          ||.
Mouse   695 GPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWR----YNLSQPSEAPPLAVHDEAEKR 755

  Fly   627 LSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESM 691
            |.:..|.||.....|.::.:..|...||..|:::||||||.||:|||||||||||:||.||..:|
Mouse   756 LPRASLVLLSKFQPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAM 820

  Fly   692 LGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAA 756
            :.:||::.::|.:|..||.||||||||||||||||||||||.|||:|||||||||||.||||||:
Mouse   821 VNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQAS 885

  Fly   757 WVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFY 821
            ||.:|...||||||.|||..||||:||||||:||..||...::.|.|...:.:||:.||||||||
Mouse   886 WVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSSGFPKAAKLFLLKWSFY 950

  Fly   822 SSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICE 873
            |||:|||||||||:|||||||||||:||||:||:||::|:|:.:|.|||:.|
Mouse   951 SSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGE 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	63/75 (84%)
Rfx1	XP_011246631.1	RFX1_trans_act	214..467	CDD:461362	45/285 (16%)
		RFX_DNA_binding	531..608	CDD:460512	63/76 (83%)