Protein Alignment CG42795 and USP6NL

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: XP_006717605.1
• Gene: USP6NL / 9712
• HGNCID: 16858
• Length: 856
• Species: Homo sapiens
• Alignment Length: 939
• Identity: 187/939 - (19%)
• Similarity: 299/939 - (31%)
• Gaps: 284/939 - (30%)

  Fly   199 DEATSDYN---------------QWLHAM----------KLVARLPGGTPPEFRRKLWLSL---- 234
            :|...|:|               :||..:          |...|:..|.|.:.|.::|..|
Human    81 EEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIP 145

  Fly   235 ------ADKYLKSKNVDWAQQREKCFCEEWREDDEELGIQIVKDLHRT-GSNLCTGPAGSINQAK 292
                  .|.|.|.|:      |.:....:.|        ||..|::|| ..::.......:.|..
Human   146 KMKEETRDLYSKLKH------RARGCSPDIR--------QIDLDVNRTFRDHIMFRDRYGVKQQS 196

  Fly   293 LKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMKVMIYLVEGVLPT----GYFYGSMG 353
            |..:|..|:.||.|||||||.:.:.||:|..|:  ||::...::.|..|  |.    |:|.....
Human   197 LFHVLAAYSIYNTEVGYCQGMSQITALLLMYMN--EEDAFWALVKLFSG--PKHAMHGFFVQGFP 257

  Fly   354 GLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLRVW 418
            .|........:::...|.:|.:||..         :...|:.:||:||...|....|.:..||:|
Human   258 KLLRFQEHHEKILNKFLSKLKQHLDS---------QEIYTSFYTMKWFFQCFLDRTPFTLNLRIW 313

  Fly   419 DLVLIEGSDVLLRTALVLWSLLEERV--ISVRSADEFYGKMGSYSSELLNGHLVDSNGLIERVVK 481
            |:.:.||..||...:..:..|.::.:  :|:....||      :...|......:.:.:||: ::
Human   314 DIYIFEGERVLTAMSYTILKLHKKHLMKLSMEELVEF------FQETLAKDFFFEDDFVIEQ-LQ 371

  Fly   482 LGPIEDLRQLRDKHLYNIAPLRHKQGLQLYYDEEDTHSDEERLAVATVFGLNWGRRGSVG---PA 543
            :...|..|...|      .|   :.|.:..|.::........|....|..|:.|:| |||   |.
Human   372 ISMTELKRAKLD------LP---EPGKEDEYPKKPLGQLPPELQSWGVHHLSNGQR-SVGRPSPL 426

  Fly   544 AAGKQQVEQKDRLALDISLLKKQYDRLRERQKQAHVILTTACSTAARQGSGPASSSQPAVPVNQL 608
            |:|:::.....|                                  |....|...|
Human   427 ASGRRESGAPHR----------------------------------RHEHSPHPQS--------- 448

  Fly   609 LLGRPAIVTNKGKRVGAPLGAIPPARK-------------------PSLP---------AVLHTK 645
                         |.|.|..|.||.||                   ||.|         |..:..
Human   449 -------------RTGTPERAQPPRRKSVEEESKKLKDEADFQRKLPSGPQDSSRQYNHAAANQN 500

  Fly   646 PTSEKQLRRGETLLW-RDTDPSRRRRDSLTWKEIKADRAAMIREGVDV---SSVRTQKLRTRFGK 706
            ..:...:|:.....| :.:|.|...|.:....|.|. |||.....|.|   :.||...:|.:...
Human   501 SNATSNIRKEFVPKWNKPSDVSATERTAKYTMEGKG-RAAHPALAVTVPGPAEVRVSNVRPKMKA 564

  Fly   707 SDSSSYSEDSDGEQESGTGG---GGGSSTDTSLCDDDDPKSTEKSPKQKAKLARKLKEQKQLAGS 768
            .|:......|...|.....|   ..|:|.:.:|     .::..:||:. |......::..:.:.|
Human   565 LDAEDGKRGSTASQYDNVPGPELDSGASVEEAL-----ERAYSQSPRH-ALYPPSPRKHAEPSSS 623

  Fly   769 RETSLERQRPKSWAPSSHEIPFMLMGTDSGDEKEDKSTKEGPITGDQAEDSATESGHYEFDRELH 833
            ......:...|...||....|..|.|...|.......:......|:..:...|.:..:.
Human   624 PSKVSNKFTFKVQPPSHARYPSQLDGEARGLAHPPSYSNPPVYHGNSPKHFPTANSSFA------ 682

  Fly   834 LVSSKMEPLKLPFDPEFTGMTSVSPIPTPREKSEAEEDLLDERKPFDVSDDGVTNQYFERVNSVE 898
                         .|:|:..|.::|...|...:     |.....|               ..|..
Human   683 -------------SPQFSPGTQLNPSRRPHGST-----LSVSASP---------------EKSYS 714

  Fly   899 RPNRLELTYSLNEE-ETDTNAIYLEEREKVEGHSGDREYNSLPPFYPRENDDGVQGGGK--VPQI 960
            ||:.|.|..|..|. ..||.|         .|:||               :.|....||  :|.:
Human   715 RPSPLVLPSSRIEVLPVDTGA---------GGYSG---------------NSGSPKNGKLIIPPV 755

  Fly   961 RDDNIPGENKDDYKELLSMTIEENTVYKPPTPTASTLSNASRKRRDPRRKTLTRSSTIEIEERYQ 1025
              |.:| :|:        ...|.:..|:|.|...|...:|||...                .:|.
Human   756 --DYLP-DNR--------TWSEVSYTYRPETQGQSWTRDASRGNL----------------PKYS 793

  Fly  1026 ALERRISQDQ----PSGDRQAKYIPSTAA 1050
            |.:....||.    .|.|...:|..|.||
Human   794 AFQLAPFQDHGLPAVSVDSPVRYKASPAA 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	50/179 (28%)
		DUF4682	560..689	CDD:464830	25/157 (16%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
USP6NL	XP_006717605.1	TBC	125..340	CDD:214540	61/241 (25%)
		PHA03247	<422..751	CDD:223021	77/454 (17%)