Protein Alignment CG42795 and EVI5

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: XP_016857758.1
• Gene: EVI5 / 7813
• HGNCID: 3501
• Length: 930
• Species: Homo sapiens
• Alignment Length: 1208
• Identity: 219/1208 - (18%)
• Similarity: 386/1208 - (31%)
• Gaps: 450/1208 - (37%)

  Fly   136 SARLTSPTK--NSLSSNNTITTPGSNNRSPS---------------------STKTTMLTRNGGG 177
            ::::.||:.  ::.||:.|::||..:..|||                     :...::.:.||
Human    46 ASQVASPSTSLHTTSSSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNG-- 108

  Fly   178 HGTSPTASGSGHAPSATAAAD--------------------------DEATSDYNQWL------- 209
               |...|||....|::|:::                          ::....:..|:
Human   109 ---SRRNSGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKPFECWVLYHHSQL 170

  Fly   210 -----------HAMKLVARLPGGTPPEFRRKLWLSLADKY---LKSKNVDWAQQREKCFCEEWRE 260
                       |..:||.:   |.|..||..:|..|....   :|.:..:..:....|
Human   171 CRFQVHYLKRSHTEELVHK---GIPHHFRAIVWQLLCSAQSMPIKDQYSELLKMTSPC------- 225

  Fly   261 DDEELGIQIVKDLHRT-GSNLCTGPAGSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVM 324
              |:|   |.:|:.|| ..:.......|:.|..|..::..|:..:.|||||||...:..|:|  |
Human   226 --EKL---IRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLL--M 283

  Fly   325 DKEEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFE 389
            ...|||:..|.:.|::.......|..||..|...|..|..::|..||.|..|.|      ..:|.
Human   284 QMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQ------SQSFH 342

  Fly   390 PPLTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVISVRSADEFY 454
               |:::...||||:|.|..|:....|::|:.:.||.:::.|..|.|..:.:
Human   343 ---TSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQ------------- 391

  Fly   455 GKMGSYSSELLNGHLVDSNGLIERVVKLGPIEDLRQLRDKHLYNIAPLRHKQ-GLQLYYDEEDTH 518
                   :||:.   :|..|:::...|:.|          |.::..|.:..| ..|:.|:.:...
Human   392 -------AELMQ---LDMEGMLQHFQKVIP----------HQFDGVPDKLIQAAYQVKYNSKKMK 436

  Fly   519 S-DEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLLKKQYDRLRERQKQAHVILT 582
            . ::|...:.|               ...::|||.| ||..:..|||::.:.|.:.
Human   437 KLEKEYTTIKT---------------KEMEEQVEIK-RLRTENRLLKQRIETLEKE--------- 476

  Fly   583 TACSTAARQGSGPASSSQPAVPVNQLLLGRPAIVTNKGKRVGAPLGAIPPARKPSLPAVLHTKPT 647
             :.|.|.|...|..:.:|.| ..|.|:                         |..|..:......
Human   477 -SASLADRLIQGQVTRAQEA-EENYLI-------------------------KRELATIKQQSDE 514

  Fly   648 SEKQLRRGETLLWRDTDPSRRRRDSLTWKEIKADRAAMIREGVDVSSVRTQKLRTRFGKSDSSSY 712
            :..:|.:.|..:       |:.:....|.:.                              ||:|
Human   515 ASAKLEQAENTI-------RKLQHQQQWHKC------------------------------SSNY 542

  Fly   713 SED--------------SDGEQESGTGGGGGSSTDTSLCDDDDPKSTEKSPKQKAKLARKLKEQK 763
            :||              |:.|.:...........|....::..|.....:..|:..:|.||:|.:
Human   543 NEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAE 607

  Fly   764 QLAGSRETSLERQRPKSWAPSSHEIPFMLMGTDSGDEKEDKSTKEGPITGDQAEDSATESGHYEF 828
            .:.|.:|.   ||:.|                   |.:|                      |::
Human   608 AIMGLKEL---RQQVK-------------------DLEE----------------------HWQ- 627

  Fly   829 DRELHLVSSKMEPLKLPFDPEFTGMTSVSPIPTPREKSEAEEDLLDERKPFDVSDDGVTNQYFER 893
             |.|...:.:.:      ||           |.....:|.:::|:..|.. :........:..:|
Human   628 -RHLARTTGRWK------DP-----------PKKNAMNELQDELMTIRLR-EAETQAEIREIKQR 673

  Fly   894 VNSVERPNRLELTYSLNEEETDTNAIYLEEREKVEGHSGDREYNSLPPFYPRENDDGVQGGGKVP 958
            :..:|..|::...:....|:   ..|.|:|                                ||.
Human   674 MMEMETQNQINSNHLRRAEQ---EVISLQE--------------------------------KVQ 703

  Fly   959 QIRDDNIPGENKDDYKELLSMTIEENTVYKPPTPTASTLSNASRKRRDPRRKTLTRSSTIEIEER 1023
            .:...|         |.||:.                 ||.|.||:.:           ||.:.:
Human   704 YLSAQN---------KGLLTQ-----------------LSEAKRKQAE-----------IECKNK 731

  Fly  1024 YQALERRISQDQPSGDRQAKYIPSTAALEERFNTLEKQLSAEKQRKELSEMEAEYPIKSERIPST 1088
            .:.:..|:        |:|..|.:.|.|.:....||.|....|.:.:|:        ||:.....
Human   732 EEVMAVRL--------READSIAAVAELRQHIAELEIQKEEGKLQGQLN--------KSDSNQYI 780

  Fly  1089 ADLESRFNSLTKQ-----------------------MSSSESSSKTPIDLKDEDRPSGSSSKNQ- 1129
            .:|:.:...|..:                       ||..:.||.|...||.:...||....:.
Human   781 GELKDQIAELNHEGELGREGRNVIPDWHSPHAEGNLMSGKQHSSPTLRCLKGQRGFSGQPPFDGI 845

  Fly  1130 -------KDSEKTSKLHKSEEP-ESNTKETTG------ETEASDSNDSKIGEKETEQPRIKKLPS 1180
                   .|.|   ..|.|:|. ..|:.:.||      ....|.|.|..:.:           .|
Human   846 HIVNHLIGDDE---SFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVAD-----------GS 896

  Fly  1181 TAELEDRFNALERKMSVQKSSPSKNKKEPPDEEESKST 1218
            .:|.||  :.||    .::|:....|:.||...||.||
Human   897 ESETED--SVLE----TRESNQVVQKERPPRRRESYST 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	51/175 (29%)
		DUF4682	560..689	CDD:464830	18/128 (14%)
		PTZ00121	<1112..2009	CDD:173412	29/122 (24%)
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
EVI5	XP_016857758.1	TBC	187..395	CDD:214540	63/253 (25%)
		Smc	<433..>752	CDD:440809	81/551 (15%)