Protein Alignment CG42795 and tbc1d1

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: XP_031751223.1
• Gene: tbc1d1 / 733547
• XenbaseID: XB-GENE-5959648
• Length: 1286
• Species: Xenopus tropicalis
• Alignment Length: 581
• Identity: 124/581 - (21%)
• Similarity: 222/581 - (38%)
• Gaps: 164/581 - (28%)

  Fly    30 CRDPVHKRSPKKKKGQLAQLAS-----------------GMVGDRSSLERLD----VRKLIDVCA 73
            |..||..|....::....::|:                 |.:..||.||.:.    ||..:.|..
 Frog   765 CESPVRTRRHSWRQQIFLRVATPQKGCDSPNRYDDHSDLGDIAPRSPLEPVSEDGPVRSAVAVRH 829

  Fly    74 ILKVEI--LMLGYLLERVLVARDRLQRHQEVLCEFVTAVLIVESDDAQPKMRFSLS----PPPQK 132
            ....|:  |....:|:::|:.|...:..:          |....:|.|.| |..|.    .|..|
 Frog   830 RTTEELRELWKKAILQQILLLRMEKENQK----------LQASENDLQNK-RLKLDYEEITPCLK 883

  Fly   133 AITSARLTSPTKNSLSSNNTITTPGSNNRSPSSTKTTMLTRNGGGHGTSPTASGSGHAPSATAAA 197
            .:|           |.....::|||   ||...|.|.
 Frog   884 DVT-----------LVWEKMLSTPG---RSKIKTDTE---------------------------- 906

  Fly   198 DDEATSDYNQWLHAMKLVARLPGGTPPEFRRKLWLSLADKY-LKSKNVDWAQQREKCFCEEWRED 261
                           |:.|.:..|.|.:.|.::|..|:::| |:.:::...|.::    ..::|.
 Frog   907 ---------------KIHAAVGQGVPRQHRGEIWKFLSEQYQLRHQHISKNQLKD----TPYKEL 952

  Fly   262 DEELGIQ---IVKDLHRTGSNLCTGPAGS----INQAKLKRILLGYARYNPEVGYCQGFNMLGAL 319
            .::|..|   |:.||.||   ..|.|..|    ..|..|..||..|:..:||||||||.:.:..:
 Frog   953 LKQLTTQQHAILIDLGRT---FPTHPYFSAQLGAGQLSLYNILKAYSLLDPEVGYCQGLSFVAGV 1014

  Fly   320 ILQVMDKEEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQ-GP 383
            :|  :...||::.|::.:|:..:.....:...|..||..|.....|:......|..||:..: ||
 Frog  1015 LL--LHMTEEDAFKMLKFLMYDLGLRKQYRPDMITLQIQMYQLSRLLHDYHRDLYNHLETYEIGP 1077

  Fly   384 VENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVISVR 448
                      :::...||||||.:..|:..|.||:|::.::||:|:.:.||.|
 Frog  1078 ----------SLYAAPWFLTMFASQFPLGFVARVFDMIFLQGSEVIFKVALSL------------ 1120

  Fly   449 SADEFYGKMGSYSSELLNGHLVDSNGLIERVVKLGPIEDLRQLRDKHLYNIAPLRHKQGLQLYYD 513
                    :||:...:|....::|  ::|.:....|...|.|: :|.:..:..:...:.||.|
 Frog  1121 --------LGSHKPLILQHENLES--IVEFIKNTLPNLGLVQM-EKTINQVFEMDISKQLQAY-- 1172

  Fly   514 EEDTHSDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLLKKQYDRLRERQ 574
            |.:.|..::.|..::....|              |::.:.::  .:.:|.|:.:|.|.|.|
 Frog  1173 EVEYHVLQDELIDSSPLSDN--------------QRINKLEK--ANSTLRKQNFDLLEELQ 1217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	54/182 (30%)
		DUF4682	560..689	CDD:464830	6/15 (40%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
tbc1d1	XP_031751223.1	PTB_TBC1D1_like	166..397	CDD:269967
		DUF3350	805..860	CDD:463365	12/64 (19%)
		TBC	912..1129	CDD:214540	66/255 (26%)
		SMC_prok_B	<1150..>1269	CDD:274008	17/87 (20%)