Protein Alignment CG42795 and tbc1d8b

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: XP_009299628.1
• Gene: tbc1d8b / 566657
• ZFINID: ZDB-GENE-030131-3135
• Length: 1152
• Species: Danio rerio
• Alignment Length: 832
• Identity: 173/832 - (20%)
• Similarity: 281/832 - (33%)
• Gaps: 259/832 - (31%)

  Fly   214 LVARLPGGTPPEFRRKLWL--SLADKYLKSKNVDWAQQREKCF------CEEWREDDEELGIQIV 270
            |:.|   |.|...|.:||:  |.|...:.|....:.:..|.|.      |:|           |.
Zfish   465 LIVR---GVPETLRGELWMLFSGAVHDMISHPGYYGRLLEDCMGSSSLACDE-----------IE 515

  Fly   271 KDLHRTGSNLCTGPA--GSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMK 333
            :||||   :|...||  .....:.|:|:|..||..||::||||..|:|.:::|  :..:|||:..
Zfish   516 RDLHR---SLPEHPAFQSDTGISALRRVLTAYAHRNPKIGYCQAMNILTSVLL--LYAKEEEAFW 575

  Fly   334 VMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTM 398
            :::.:.|.:|| .||...:.|...|..||.||::..|.:|.:|:..|.          ..:..::
Zfish   576 LLVAVCERMLP-DYFNRRIIGALVDQAVFEELIREHLTQLTEHMTDLS----------FFSSVSL 629

  Fly   399 QWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVI-------SVRSADEFYGK 456
            .||||:|.:.||:...:.|.|....:|...:|:..|.:.....:.::       :|...:.|:..
Zfish   630 SWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAVLDYNMDNLLCCNDDAEAVTVLNRFFDS 694

  Fly   457 MGSYSSEL-------------LNGHLVDSNGLI-ERVVKLGPI--EDLRQLRDKH-LYNIAPLRH 504
            :.:..|.|             .:...||.:.|| |...|.|.|  |::..:|.:: ||.|..|
Zfish   695 VTNKDSPLPATVQQASATANDKSIQKVDISDLIKEAYEKYGDIRTEEVENMRKRNKLYVIQTL-- 757

  Fly   505 KQGLQLYYDEEDTHSDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLLKKQYDR 569
                      |||                            .||.|.:.  :|.|:.....|.|.
Zfish   758 ----------EDT----------------------------TKQNVLRV--VAQDVKFSASQLDE 782

  Fly   570 LRERQKQAHVILT--TACSTAARQGSGPASSSQPAVPVNQLLLGRPAIVTNKGKRVGAPLGAIPP 632
            |....|:.|.:..  :.||.|.:.
Zfish   783 LYLLFKRQHFVCCYWSVCSPALQN----------------------------------------- 806

  Fly   633 ARKPSLPAVLHTKPTSEKQLRRGETLL--WRDTDPSRR-RRDSLTWKEIKADRAAMIRE---GVD 691
             ..|||| .|......:.|......||  |.....||. .|.:....:...|.....:|   |:|
Zfish   807 -HDPSLP-YLDQYQLDQSQFSSLFNLLQPWTTHTHSRSLARSAFHLLDENGDGLVNFKEFICGLD 869

  Fly   692 VSSVR--TQKLRTRF------GKSD-----SSSYSEDSDGEQESGTGGGGGSSTDTSLCDDDDPK 743
            :...|  |:||:..|      |..:     ||.:...           |...|..|.|.|..:..
Zfish   870 ILYNRSFTEKLKLLFKLHLQPGNQECKILPSSRFFPP-----------GEDHSFSTRLSDSAEDG 923

  Fly   744 STEKSPKQ---KAKLARKLKEQKQLAGSRETSLERQRPKSWAPSSHEIPFM-----LMGTDSGDE 800
            ...|.|::   |..|...||:.::....||.:::.      .|..:::.|:     |.....|||
Zfish   924 VIRKCPERGRAKVDLQEYLKQWQEDLQRREENIKD------LPRINQVQFISLTKTLYSVFHGDE 982

  Fly   801 KED-----------------------------KSTKEGPITGDQAEDSATESGHYEFDRELHLVS 836
            :|:                             |:.:..|.:..|.|.|.|:....|.:......|
Zfish   983 EEESLYRAVARVTSLLLRMEEVGRKLQDSSPQKTPQTTPTSTSQPESSPTKPTSPESETPAESRS 1047

  Fly   837 SKMEPLK-------LPFDPEFTGMTSVSPIPTPREKSEAEEDLLDERKPFDVSD------DGVTN 888
            :..:|..       .|...:.|..::..|.......:|....:||  .|.|...      ||..:
Zfish  1048 THDQPESPVSQHETAPSHSDITPNSTSHPSTPTSSPTETSSPVLD--TPTDTPSSPCTVRDGDWS 1110

  Fly   889 QYFERVNSVERPNRLELTYSLNEE----------ETDTNAIYLEEREKVEGH 930
            ..||::          |...|||.          .|||......:.:..:.|
Zfish  1111 FSFEQI----------LASLLNEPSVVRFFERVVNTDTLITRARKNQLKDAH 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	52/176 (30%)
		DUF4682	560..689	CDD:464830	22/136 (16%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
tbc1d8b	XP_009299628.1	PH-like	154..252	CDD:473070
		PH-GRAM2_TBC1D8B	294..386	CDD:270159
		TBC	468..676	CDD:214540	65/237 (27%)
		PRK12495	<1028..1144	CDD:183558	25/127 (20%)