Protein Alignment CG42795 and TBC1D8B

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_060222.2
• Gene: TBC1D8B / 54885
• HGNCID: 24715
• Length: 1120
• Species: Homo sapiens
• Alignment Length: 1019
• Identity: 196/1019 - (19%)
• Similarity: 340/1019 - (33%)
• Gaps: 377/1019 - (36%)

  Fly    90 LVARDRL-------QRHQEVLCEFVTAVLIVESDDAQPKMRFSLSPPPQKAITSARLTSPTKNSL 147
            |||:.||       |.|.      ::..|.:.|:..:|...|.:     :::||.|..|.|.|:.
Human   380 LVAKLRLRCGAASTQYHD------ISTELAISSESTEPSDNFEV-----QSLTSQRECSKTVNTE 433

  Fly   148 SSNNTITTPGSNNRSPSSTKTTMLTRNGG------GHGTSPTASGSGHAPSATAAADDEATSDYN 206
            :.............:....|..|..::..      |.|.|...:              :.|.|
Human   434 ALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRT--------------KKTRD-- 482

  Fly   207 QWLHAMKLVARLPGGTPPEFRRKLWL----SLADKYLKSKNVDWAQQREKCFCEEWREDDEELGI 267
                   ||.|   |.|...|.:||:    ::.|   .:.|.|:..:          ..::.||.
Human   483 -------LVVR---GIPETLRGELWMLFSGAVND---MATNPDYYTE----------VVEQSLGT 524

  Fly   268 ------QIVKDLHRTGSNLCTGPA--GSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVM 324
                  :|.:||.|   :|...||  .....:.|:|:|..||..||::||||..|:|.:::|  :
Human   525 CNLATEEIERDLRR---SLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLL--L 584

  Fly   325 DKEEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGPVENAFE 389
            ..:|||:..:::.:.|.:|| .||...:.|...|..||.||::..||:|.:|:.          :
Human   585 YAKEEEAFWLLVAVCERMLP-DYFNRRIIGALVDQAVFEELIRDHLPQLTEHMT----------D 638

  Fly   390 PPLTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTALVLWSLLEERVI-------SV 447
            ....:..::.||||:|.:.||:...:.|.|....:|...:|:..|.:.....::::       :|
Human   639 MTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAV 703

  Fly   448 RSADEFYG-------------KMGSYSSELLNGHL-VDSNGLI-ERVVKLGPI--EDLRQLRDKH 495
            .:.:.|:.             :.||..|:....|. ||...|| |...|.|.|  ||:..:|.::
Human   704 TALNRFFDNVTNKDSPLPSNVQQGSNVSDEKTSHTRVDITDLIRESNEKYGNIRYEDIHSMRCRN 768

  Fly   496 -LYNIAPLRHKQGLQLYYDEEDTHSDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALD 559
             ||.|..|           ||.|..:..|:....|                 |..:::.|.|.:
Human   769 RLYVIQTL-----------EETTKQNVLRVVSQDV-----------------KLSLQELDELYV- 804

  Fly   560 ISLLKKQYDRLRERQKQAHVILTTACSTAARQGSGPASSSQPAVPVNQLLLGRPAIVTNKGKRVG 624
              :.||:              |..:|                     ...||.|.:
Human   805 --IFKKE--------------LFLSC---------------------YWCLGCPVL--------- 823

  Fly   625 APLGAIPPARKPSLPAVLHTKPTSEKQLRRGETLL--WRDTDPSRRRRDSL---TWKEIKADRAA 684
                   ....|||| .|.......:|.|....||  |..:    ..:|||   |::.:..:...
Human   824 -------KHHDPSLP-YLEQYQIDCQQFRALYHLLSPWAHS----ANKDSLALWTFRLLDENSDC 876

  Fly   685 MIR-----EGVDV--SSVRTQKLRTRFGKSDSSSYSEDSDGEQESGTGGGGGSSTDTSLCDDDDP 742
            :|.     ..:|:  :...|:||:..|......:|:|              ..|.|.|..|:
Human   877 LINFKEFSSAIDIMYNGSFTEKLKLLFKLHIPPAYTE--------------VKSKDASKGDE--- 924

  Fly   743 KSTEKSPKQKAKLARKLKEQKQLAGSRETSLERQRPKSWAPSSHEIPFMLMGTDSGDEKEDKSTK 807
                            |.:::.|..|:   |...:|                   .:|||.:|.|
Human   925 ----------------LSKEELLYFSQ---LHVSKP-------------------ANEKEAESAK 951

  Fly   808 EGPITGDQAEDSATESGHYEFDRELHLVSSKMEPLKLPFDPEFTGMTSVSPIPTPREKSEAEEDL 872
            ..|           |.|..:.|.:.:|                               |:.:::|
Human   952 HSP-----------EKGKGKIDIQAYL-------------------------------SQWQDEL 974

  Fly   873 LDERKPFDVSDDGVTNQYFERVNSVERPNRLELTYSLNEEETDTNAIY---------LEEREKVE 928
            .  :|..::.|       ..|:|..:.....:..|:|..|:.:..::|         |...|:|
Human   975 F--KKEENIKD-------LPRMNQSQFIQFSKTLYNLFHEDPEEESLYQAIAVVTSLLLRMEEV- 1029

  Fly   929 GHSGDREYNSLPPFYPRENDDGVQG-----GGKVPQIRDDNIPGENKDD---------------- 972
                .|:.:|     |..:..|..|     ||          |.|.|..
Human  1030 ----GRKLHS-----PTSSAKGFSGTVCGSGG----------PSEEKTGSHLEKDPCSFREEPQW 1075

  Fly   973 ---YKELLSMTIEENTV---YKPPTPTASTLSNASRKRRDPRRK 1010
               ::::|:..:.|..:   ::.|....:.|.||...:...|.|
Human  1076 SFAFEQILASLLNEPALVRFFEKPIDVKAKLENARISQLRSRTK 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	51/176 (29%)
		DUF4682	560..689	CDD:464830	22/138 (16%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
TBC1D8B	NP_060222.2	PH-GRAM1_TBC1D8B	156..254	CDD:275419
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	5/7 (71%)
		TBC	486..694	CDD:214540	62/239 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1066		9/45 (20%)