Protein Alignment CG42795 and RABGAP1

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_036329.3
• Gene: RABGAP1 / 23637
• HGNCID: 17155
• Length: 1069
• Species: Homo sapiens
• Alignment Length: 742
• Identity: 151/742 - (20%)
• Similarity: 277/742 - (37%)
• Gaps: 196/742 - (26%)

  Fly    84 YLLE---RVLVARDRL---------------------QRHQEVLCEFVTAVLIVESDDAQPKMRF 124
            :|||   ||....:||                     ||.::...:.:..|:.:||:..:.:.:.
Human   424 FLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRERKNNTDTLYEVVCLESESERERRKT 488

  Fly   125 SLSPP---PQKAITSARLTSPTKNSLSSNNTITTPGSNNRSPSSTKTTMLTRNGGGHGTSPTASG 186
            :.||.   ||....|:.:.||.::....:|                            ..|..||
Human   489 TASPSVRLPQSGSQSSVIPSPPEDDEEEDN----------------------------DEPLLSG 525

  Fly   187 SGHAPSATAAADDEATSD-YNQW-----LHAMKLVARLPGGTPPEFRRKLWLSLADKYLKSKNVD 245
            ||......|....|...: .::|     :...:|.:.:..|.|...|.::|..||..:    |.|
Human   526 SGDVSKECAEKILETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCH----NND 586

  Fly   246 WAQQREKCFCEEWREDDEELGIQIVKDLHRTGSNLCTGPA-------GSINQAKLKRILLGYARY 303
            ...::.:....:....|.    .|.:|::|      |.||       |...|..|.:|...|:.|
Human   587 HLVEKYRILITKESPQDS----AITRDINR------TFPAHDYFKDTGGDGQDSLYKICKAYSVY 641

  Fly   304 NPEVGYCQGFNMLGALILQVMDKEEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGVFRELMQT 368
            :.|:|||||.:.|.|::|..|.:|:..|:.|.|....|:  ...|..:...|.........|||.
Human   642 DEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGL--RELFKQNFEDLHCKFYQLERLMQE 704

  Fly   369 RLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLLRTA 433
            .:|.|..|.      ::.:.|   .:::..|||||:|....|:..|..:.||:|.||..|:...|
Human   705 YIPDLYNHF------LDISLE---AHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVA 760

  Fly   434 LVLWSLLEERVISVRSADEFYGKMGSYSSELLNGHLVDSNGLIERVVKLGPIEDLRQLRDKHLYN 498
            |.|....::.::    ..:|.|.:..:..:|...:..:.|.  :::::|.....:.|.:
Human   761 LGLLKTSKDDLL----LTDFEGALKFFRVQLPKRYRSEENA--KKLMELACNMKISQKK------ 813

  Fly   499 IAPLRHKQGLQLYYDEEDTHSDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLL 563
                     |:.|  |::.|:..|                         ||.:|:|    .|...
Human   814 ---------LKKY--EKEYHTMRE-------------------------QQAQQED----PIERF 838

  Fly   564 KKQYDRLRE---RQKQ-----AHVILTTACSTAARQGSGPASSSQPAVPVNQLLLGRPAIVTNKG 620
            :::..||:|   |.:|     ||.::|:  ..|.|:....|.....|:....|:..:..|...:.
Human   839 ERENRRLQEANMRLEQENDDLAHELVTS--KIALRKDLDNAEEKADALNKELLMTKQKLIDAEEE 901

  Fly   621 KRVGAPLGAIPPARKPSLPAVLHTKPTSEKQLRRGETLLWRDTDPSRRRRDSL--TWKEIKADRA 683
            ||           |.....|.|  |....::|.:.|:.:        ::..|:  .:|:|.:..:
Human   902 KR-----------RLEEESAQL--KEMCRRELDKAESEI--------KKNSSIIGDYKQICSQLS 945

  Fly   684 AMIREGVDVSSVRTQKLRTRFGKSDSSSYSEDSDGEQESGTGGGGGSSTDTSLCDDDDPKSTEKS 748
            ..:.:....:.|..:|:|.:....:......:.:|..:      |.|||...|.:|.|
Human   946 ERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVK------GISSTKEVLDEDTD------- 997

  Fly   749 PKQKAKLARKLKEQK-QLAGSRETSLE 774
             ::|..|..:|:|.: :||   :|.|:
Human   998 -EEKETLKNQLREMELELA---QTKLQ 1020

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	53/181 (29%)
		DUF4682	560..689	CDD:464830	26/138 (19%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
RABGAP1	NP_036329.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..79
		PTB_Rab6GAP	145..273	CDD:269922
		DUF3694	307..437	CDD:463599	5/12 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..527		11/72 (15%)
		TBC	563..772	CDD:214540	62/233 (27%)
		SMC_prok_B	<825..>1032	CDD:274008	50/265 (19%)