Protein Alignment CG42795 and TBC1D1

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: XP_011511961.1
• Gene: TBC1D1 / 23216
• HGNCID: 11578
• Length: 1295
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 115/520 - (22%)
• Similarity: 194/520 - (37%)
• Gaps: 147/520 - (28%)

  Fly   128 PPPQKAITSARLTSPTKNSLSSNNTITTPGSNNRSPSSTKTTMLTRNGGGHGTSPTASGSGHAPS 192
            ||.:|..||..|....:.::.....:......|:...:::..:|.:
Human   836 PPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNK------------------- 881

  Fly   193 ATAAADDEATSDYNQWLHAMKLVARL-------PG-----------------GTPPEFRRKLWLS 233
                   ....||.:....:|.|..:       ||                 |.|...|.::|..
Human   882 -------RLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKF 939

  Fly   234 LADKY-LKSKNVDWAQQREKCFCEEWREDDEELGIQ---IVKDLHRTGSNLCTGPAGS----INQ 290
            ||::: ||.:.....|.::    ..::|..::|..|   |:.||.||   ..|.|..|    ..|
Human   940 LAEQFHLKHQFPSKQQPKD----VPYKELLKQLTSQQHAILIDLGRT---FPTHPYFSAQLGAGQ 997

  Fly   291 AKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDKEEEESMKVMIYLVEGVLPTGYFYGSMGGL 355
            ..|..||..|:..:.|||||||.:.:..::|  :...|||:.|::.:|:
Human   998 LSLYNILKAYSLLDQEVGYCQGLSFVAGILL--LHMSEEEAFKMLKFLM---------------- 1044

  Fly   356 QADMGVFRE------LMQTRLPRLAKHLQRLQGPVENAFE-----PPLTNVFTMQWFLTMFCTCL 409
             .|||:.::      ::|.::.:|::.|......:.|..|     |.|   :...||||||.:..
Human  1045 -FDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSL---YAAPWFLTMFASQF 1105

  Fly   410 PMSCVLRVWDLVLIEGSDVLLRTALVLWSL----------LEERVISVRSADEFYGKMGSYSSE- 463
            |:..|.||:|::.::|::|:.:.||.|...          ||..|..::|.   ...:|....|
Human  1106 PLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKST---LPNLGLVQMEK 1167

  Fly   464 ------------LLNGHLVDSNGLIERVVKLGPIEDLRQLRDKHLYNIAPLRHKQGLQLYYDEED 516
                        .|..:.|:.:.|.|.::...|:.| .|..||.....:.|| ||.|.|.
Human  1168 TINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSD-NQRMDKLEKTNSSLR-KQNLDLL----- 1225

  Fly   517 THSDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDR-----LALDISLLKKQYDRLRERQKQ 576
                 |:|.||.      ||..|:..........|.|.:     |.|:.|.|.:..:.||.|..:
Human  1226 -----EQLQVAN------GRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAE 1279

  Fly   577  576
            Human  1280  1279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	55/202 (27%)
		DUF4682	560..689	CDD:464830	5/17 (29%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
TBC1D1	XP_011511961.1	PTB	21..150	CDD:269911
		PTB_TBC1D1_like	164..391	CDD:269967
		DUF3350	817..872	CDD:463365	7/35 (20%)
		TBC	924..1141	CDD:214540	64/245 (26%)
		ZapB	1221..1283	CDD:442308	18/75 (24%)