Protein Alignment CG42795 and TBC1D9B

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: NP_942568.2
• Gene: TBC1D9B / 23061
• HGNCID: 29097
• Length: 1250
• Species: Homo sapiens
• Alignment Length: 1038
• Identity: 208/1038 - (20%)
• Similarity: 327/1038 - (31%)
• Gaps: 365/1038 - (35%)

  Fly    45 QLAQLA-------SGMVGDR------------SSLERLDVRKLIDVCAILKVEILMLGYLLERVL 90
            |||.||       .|.:.|:            |:|:|       |:.|..|.|.....:.|.|
Human   243 QLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKR-------DLDARAKNECYRATFRLPR-- 298

  Fly    91 VARDRLQRH------------------------------QEVLCEFV---TAVLIVESDDAQPKM 122
              .:||..|                              :|..|..:   ..|.|||..|:.
Human   299 --DERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSS--- 358

  Fly   123 RFSLSPPPQKAITSARLT----------------------SPTKNSLSSNNTITTPGS-NNRSPS 164
              |:.|.|....|.:::|                      :|:|.          ||| .:|..|
Human   359 --SVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQ----------PGSIGSRKAS 411

  Fly   165 ----STKTTMLTRNGGGHGTSPTASGSG-------HAPSAT-----------------AAADDEA 201
                ||:::...:.|.....||.:..|.       .||:|:                 |....|.
Human   412 VVDPSTESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEK 476

  Fly   202 TSDYNQWLH------------AMKLVARLPGGTPPEFRRKLWLSLADKYLKSKNVDWAQQREKCF 254
            ..:.:..:|            ..|..|.:..|.|...|.:|||                    .|
Human   477 MKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWL--------------------LF 521

  Fly   255 CEEWREDDEELGI-----------------QIVKDLHRTGSNLCTGPA--GSINQAKLKRILLGY 300
            ...|.|.....|.                 :|.:||||   ::...||  ..:..|.|:|:|..|
Human   522 SGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHR---SMPEHPAFQNELGIAALRRVLTAY 583

  Fly   301 ARYNPEVGYCQGFNMLGALILQVMDKEEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGVFREL 365
            |..||.:||||..|::.:::|  :...|||:..:::.|.|.:|| .|:...:.|...|.|:|.||
Human   584 AFRNPTIGYCQAMNIVTSVLL--LYGSEEEAFWLLVALCERMLP-DYYNTRVVGALVDQGIFEEL 645

  Fly   366 MQTRLPRLAKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLRVWDLVLIEGSDVLL 430
            .:..||:|::.:|.| |.:.:         .::.||||:|.:.:|....:.:.|....||..|:|
Human   646 TRDFLPQLSEKMQDL-GVISS---------ISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVIL 700

  Fly   431 RTALVLWSLLEERVISVRSADEFYGKMGSYSSELLNGHLVDSNGLIERVVKLGPIEDLRQLRD-- 493
            :.||.:.....|:::......|....:|.|...::|...|..           ||..||.|..
Human   701 QVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSP-----------PIPHLRALLSSS 754

  Fly   494 -------------KHLY---------NIAPLRHKQGLQLYYDEEDTHSDEERLAVATVFGLN--- 533
                         |..|         :|..:|.||.|::....|||.......|:....|.:
Human   755 DDPPAEVDIFELLKVSYEKFSSLRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEE 819

  Fly   534 -----------------W-------GRR---------------------GSVGPAAAGKQQVEQK 553
                             |       |||                     .|:.|.|.|..
Human   820 LEDLYMVFKAKHLASQYWGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSH----- 879

  Fly   554 DRLALDISLLKKQYDRLRERQKQA---------------HVILTTACSTAARQGSGPASSSQPAV 603
                  ..||..:..||.:..|.:               |..||.......:....||.|.:.|
Human   880 ------TPLLAGRMFRLLDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEA- 937

  Fly   604 PVNQLLLGRPAIVTNKGKRVGAPLGA-----IPPARKPSLPAVLHTKPTSEKQLRRGETLLWRDT 663
               :..|......|.......:||.:     :|...:.:||........||:   |||.   :.|
Human   938 ---ESALEAAHYFTEDSSSEASPLASDLDLFLPWEAQEALPQEEQEGSGSEE---RGEE---KGT 993

  Fly   664 DPSRRRRDSLTWKEIKADRAAMIREGVDVSSVRTQKLRTRFGKSDSSSYSED---SD-------- 717
            .....|.....|.:.|..:...|:   |:..:..::. ....|:..:.:|||   .|
Human   994 SSPDYRHYLRMWAKEKEAQKETIK---DLPKMNQEQF-IELCKTLYNMFSEDPMEQDLYHAIATV 1054

  Fly   718 -------GEQESGTGGGGGSSTDTSLCDDDDPKSTEKSPKQKAKLARKLKEQKQLAGSRETSLER 775
                   ||.........|........::|:|    .:|:.....||:|  |...||..:.....
Human  1055 ASLLLRIGEVGKKFSARTGRKPRDCATEEDEP----PAPELHQDAAREL--QPPAAGDPQAKAGG 1113

  Fly   776 QRPKSWAPSSHEI------------PFMLMGTDSGDEKEDKSTKEGPI--TGD-QAEDSATES 823
            ......||...::            |..|:..|  :.|:|.|.....:  ||. |.||.|.::
Human  1114 DTHLGKAPQESQVVVEGGSGEGQGSPSQLLSDD--ETKDDMSMSSYSVVSTGSLQCEDLADDT 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	54/176 (31%)
		DUF4682	560..689	CDD:464830	29/148 (20%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
TBC1D9B	NP_942568.2	PH-GRAM1_TCB1D9_TCB1D9B	153..251	CDD:275420	5/7 (71%)
		PH-GRAM2_TCB1D9_TCB1D9B	299..394	CDD:270161	15/99 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..443		13/55 (24%)
		TBC	505..715	CDD:214540	65/245 (27%)
		EFh	886..911	CDD:197492	3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	974..999		8/30 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1069..1093		4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1157		6/30 (20%)