Protein Alignment CG42795 and TBC1D3I

DIOPT Version :10

• Sequence 1: NP_001287272.1
• Gene: CG42795 / 41252
• FlyBaseID: FBgn0261928
• Length: 3213
• Species: Drosophila melanogaster
• Sequence 2: XP_006722286.1
• Gene: TBC1D3I / 102724862
• HGNCID: 32709
• Length: 610
• Species: Homo sapiens
• Alignment Length: 682
• Identity: 141/682 - (20%)
• Similarity: 215/682 - (31%)
• Gaps: 262/682 - (38%)

  Fly   204 DYNQWLHAMKLVARLPGGTPPEFRRKLW-LSLADKYLKSKNVDWAQ---QREKCFCEEWREDDEE 264
            |:.::..:.||:.|...|.|...|..:| :.|..:.:|.||....|   ::.|...|..:..|.:
Human   145 DWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKMKNPGRYQIMKEKGKRSSEHIQRIDRD 209

  Fly   265 LGIQIVKDL---HRTGSNLCTGPAGSINQAKLKRILLGYARYNPEVGYCQGFNMLGALILQVMDK 326
            :...:.|.:   .|.|:          .|.:|..|||.|..||||||||:..:.:.||.|..:
Human   210 VSGTLRKHIFFRDRYGT----------KQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYL-- 262

  Fly   327 EEEESMKVMIYL-------VEGV-LPTGYFYGSMGGLQADMGVFRELMQTRLPRLAKHLQRLQGP 383
            .||::...::.|       ::|. .|.|   |::.|||...   ..::.|..|:...|..:..
Human   263 PEEDAFWALVQLLASERHSLQGFHSPNG---GTVQGLQDQQ---EHVVATSQPKTMGHQDKKD-- 319

  Fly   384 VENAFEPPLTNVFTMQWFLTMFC-TCLPMSCV-------------LRVWDLVLIEGSDVLLRTAL 434
                                 .| .|.|:.|:             ||:||:.|:||...|:....
Human   320 ---------------------LCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITR 363

  Fly   435 VLWSLLEERVISVRSADEFYGKMGSYSSELLNGHLVDSNGLIERVVKLGPIEDLRQLRDKHL-YN 498
            :.:.:.::|:......    |....:.:..::....|.:.::                 ||| .:
Human   364 IAFKVQQKRLTKTSRC----GPWARFCNRFVDTWARDEDTVL-----------------KHLRAS 407

  Fly   499 IAPLRHKQGLQLYYDEEDTHSDEERLAVATVFGLNWGRRGSVGPAAAGKQQVEQKDRLALDISLL 563
            :..|..||                               |.:.|.|
Human   408 MKKLTRKQ-------------------------------GDLPPPA------------------- 422

  Fly   564 KKQYDRLRERQKQAHVILTTACSTAARQGSGPASSSQPAVPVNQLLLGRPAIVTNKGKRVGAPLG 628
                                    ...|||   |:|:| ||.:     |......||.| .||.|
Human   423 ------------------------KPEQGS---SASRP-VPAS-----RGGKTLCKGDR-QAPPG 453

  Fly   629 AIPPARKPSLPAVLHTKPTSEKQLRRGETLLWRDTDPSRRRRDSLTWKEIKADRAAMIREGVDVS 693
              ||||.|        :|            :| ...|.|..|.|....      ...:||  |..
Human   454 --PPARFP--------RP------------IW-SASPPRAPRSSTPCP------GGAVRE--DTY 487

  Fly   694 SVRTQKLRTRFGKSDSSSYSEDSDGEQESGTGGGGGS------------STDTSLCDDDDPKSTE 746
            .|.||.:       .|.:.::          ||..||            .||   .|.:.|....
Human   488 PVGTQGV-------PSPALAQ----------GGPQGSWRFLQWNSMPRLPTD---LDVEGPWFRH 532

  Fly   747 KSPKQKAKLARKLKEQKQLA--GSRETSLERQRPKSWAPSSHEIPFMLMGTDSGDEKEDKSTKEG 809
            ...:|.. ..|.:.::.|||  ...|...||.|....|||          |||     |:.|
Human   533 YDFRQSC-WVRAISQEDQLAPCWQAEHPAERVRSAFAAPS----------TDS-----DQGT--- 578

  Fly   810 PITGDQAEDSATESGHYEFDRELHLVSSKMEP 841
            |......:..|..||.....  |||.||:..|
Human   579 PFRARDEQQCAPTSGPCLCG--LHLESSQFPP 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42795	NP_001287272.1	RabGAP-TBC	268..443	CDD:459855	45/199 (23%)
		DUF4682	560..689	CDD:464830	27/128 (21%)
		PTZ00121	<1112..2009	CDD:173412
		PTZ00121	<1740..2340	CDD:173412
		PTZ00449	<2270..2610	CDD:185628
TBC1D3I	XP_006722286.1	TBC	160..373	CDD:214540	57/253 (23%)
		PHA03381	<417..>529	CDD:177618	42/215 (20%)