DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp13 and alpi.1

DIOPT Version :9

Sequence 1:	NP_649978.2	Gene:	Alp13 / 41236	FlyBaseID:	FBgn0037786	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001014375.1	Gene:	alpi.1 / 541539	ZFINID:	ZDB-GENE-050327-78	Length:	532	Species:	Danio rerio

Alignment Length:	524	Identity:	121/524 - (23%)
Similarity:	210/524 - (40%)	Gaps:	110/524 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LVAGTCLITVMVTLLCIGFMTRYEVENDVANVADVDYWKDKVATSQKIWYDKGIDELNEALR-PQ 86
            ||.|.....:::.||.:...|...:::......|..||.|:...:           |..||. |.
Zfish     3 LVYGRAPGALLLLLLALVLNTSCSLDSAAEWEKDPAYWNDQARRT-----------LQTALTLPL 56

  Fly    87 DLTYPKNVRIFVIQGIDGRDWAAFRF---PTSDASRGNTNFIWDRFPHLARLKNSCSQQFPCQVA 148
            .:...||:.:||..|:.....:|.|.   .....|...|....|.||:||..|..|..:.....|
Zfish    57 RVNRAKNIILFVGDGMGVSTVSAARILRGQMEGQSGEETILAMDTFPYLALSKTYCVDKQVADSA 121

  Fly   149 SVSRALWLGIPLD------KVPDNQQDCGRLFNATQG--PISILRQAQLAGLRTGFVTTQRI--T 203
            |.:.|...|:..:      .......:|    |.|.|  ..|:|.:|:..|...|.|||.|:  .
Zfish   122 STATAYHCGVKANAKTVGLSAKAVAYEC----NTTFGNEVFSVLHRAKAQGKSVGIVTTTRVQHA 182

  Fly   204 GPTGAALGNANGNFECDESMPLNSIKSGCQDIAQQLISDETGKFLNVLIGGGRQMLSSLVPNTKY 268
            .|..|...:.:..:..|..:|..:.:.||:|||.||:   |...::|::||||..::   |....
Zfish   183 SPAAAYAHSVSRKWYSDADVPSEARRQGCKDIATQLV---TNTDIDVILGGGRMYMT---PKGTP 241

  Fly   269 DPVDEMLCESNDG-----RNLLKDWRNQKLKESKINRIIFDLIQRRDELESLNSSSFDYLMGVMA 328
            ||  |....|:.|     :||:..|.|.:...:.      ..:..:::..:::..:.|.|||:..
Zfish   242 DP--EYSSSSHKGDRKDKKNLINVWLNARKGRNA------QYVWNKEQFNAVDVKTTDCLMGLFE 298

  Fly   329 NGDL-----SGNSKAPSLKLMVDKSLNVLTKYKQGYLLIVE-QFIPSGIDKREQLQLLNDTLV-- 385
            ..|:     ...::.||:..|.:|::.:|:|..:|:.|.|| ..|..|.........|.:|::
Zfish   299 PKDMRFEVFRNRTRDPSIVDMTEKAIQILSKNPKGFFLFVEGGRIDHGHHDGVAKLALTETIMFD 363

  Fly   386 -------NLHKDQDTLTLVLMT--------------NAIY---PKPSLD---------------- 410
                   .|..:.||||:|...              |.|:   ||.:.|
Zfish   364 RAIQRASELTSESDTLTVVTADHSHVFTFGGKTPRGNPIFGLAPKQAEDDLPYTSILYANGPGYD 428

  Fly   411 -VSEETETISLLPEIFNEAESEIQKRLHQMPSES--------LLFAQGPKSSIFQGVRKETFLAH 466
             |:.....:|:|     :...|..|:...:|.||        .::|:||.:.:|.||:::.::||
Zfish   429 HVNGTRGNVSVL-----DYYDEEYKQQAAVPLESETHGGEDVAIYAKGPMAHLFHGVKEQNYVAH 488

  Fly   467 AISH 470
            |:::
Zfish   489 AMAY 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp13	NP_649978.2	ALP_like	127..472	CDD:304875	98/416 (24%)
alpi.1	NP_001014375.1	PhoA	46..493	CDD:224699	111/481 (23%)
alpi.1	NP_001014375.1	Alk_phosphatase	61..496	CDD:278666	107/455 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593239
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.850