Protein Alignment Alp13 and ALPP

DIOPT Version :10

• Sequence 1: NP_649978.2
• Gene: Alp13 / 41236
• FlyBaseID: FBgn0037786
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001623.3
• Gene: ALPP / 250
• HGNCID: 439
• Length: 535
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 129/521 - (24%)
• Similarity: 226/521 - (43%)
• Gaps: 115/521 - (22%)

  Fly    26 GTCLITVMVTL-----LCIGFMTRYEVENDVANVADVDYWKDKVATSQKIWYDKGIDELNEA--L 83
            |.|::.:::.|     |.:|.:. .|.||.       |:|..:.|           :.|..|  |
Human     3 GPCMLLLLLLLGLRLQLSLGIIP-VEEENP-------DFWNREAA-----------EALGAAKKL 48

  Fly    84 RPQDLTYPKNVRIFVIQGIDGRDWAAFRF---PTSDASRGNTNFIWDRFPHLARLKN-SCSQQFP 144
            :|.. |..||:.||:..|:......|.|.   ...|..........||||::|..|. :..:..|
Human    49 QPAQ-TAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVP 112

  Fly   145 CQVASVSRALWLGIPLDKVPDNQQDCG-------RLFNATQG--PISILRQAQLAGLRTGFVTTQ 200
            ...|:.:..|.      .|..|.|..|       ...|.|:|  .||::.:|:.||...|.|||.
Human   113 DSGATATAYLC------GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTT 171

  Fly   201 RI--TGPTGAALGNANGNFECDESMPLNSIKSGCQDIAQQLISDETGKFLNVLIGGGRQMLSSL- 262
            |:  ..|.|......|.|:..|..:|.::.:.||||||.||||:..   ::|::||||:.:..:
Human   172 RVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMD---IDVILGGGRKYMFRMG 233

  Fly   263 VPNTKYDPVDEMLCESN-DGRNLLKDWRNQKLKESKINRIIFDLIQRRDELESLNSSSFDYLMGV 326
            .|:.:| |.|.....:. ||:||:::|    |.:.:..|.:::   |.:.:::....|..:|||:
Human   234 TPDPEY-PDDYSQGGTRLDGKNLVQEW----LAKRQGARYVWN---RTELMQASLDPSVTHLMGL 290

  Fly   327 MANGDLS-----GNSKAPSLKLMVDKSLNVLTKYKQGYLLIVE-QFIPSGIDKREQLQLLNDTLV 385
            ...||:.     .::..|||..|.:.:|.:|::..:|:.|.|| ..|..|..:....:.|.:|::
Human   291 FEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIM 355

  Fly   386 ---------NLHKDQDTLTLV--------------LMTNAIY---PKPSLDVS------------ 412
                     .|..::|||:||              |..::|:   |..:.|..
Human   356 FDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPG 420

  Fly   413 ---------EETETISLLPEIFNEAESEIQKRLHQMPSESLLFAQGPKSSIFQGVRKETFLAHAI 468
                     :.||:.|..||...::...:.:..| ...:..:||:||::.:..||:::||:||.:
Human   421 YVLKDGARPDVTESESGSPEYRQQSAVPLDEETH-AGEDVAVFARGPQAHLVHGVQEQTFIAHVM 484

  Fly   469 S 469
            :
Human   485 A 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp13	NP_649978.2	ALP_like	127..472	CDD:474031	105/410 (26%)
ALPP	NP_001623.3	Alk_phosphatase	55..490	CDD:395188	113/449 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	425..449		5/23 (22%)