DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and STP3

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_013479.3	Gene:	STP3 / 851089	SGDID:	S000004367	Length:	343	Species:	Saccharomyces cerevisiae

Alignment Length:	374	Identity:	84/374 - (22%)
Similarity:	134/374 - (35%)	Gaps:	130/374 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 AGVTSSKMTTEQSVFHG---SRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKP-------IE 162
            ||.:|| |.:.|.:.|.   ||||||:|.:..::.||   :..|.|.:. |..|.|       ::
Yeast    56 AGASSS-MLSYQLLPHSNDVSRSNSSSSFLPSVQQPT---EGSASASET-SSSASPSRSISPILK 115

  Fly   163 VAVPQQEKPHLVPTVSAPPAPLSKPASERV---IRENQVRLRRYIKDEMKYDLATGIESSRKNAA 224
            ||.|.          |...|.:|.|.|.::   .::.|..:.|.....:....||.:....:
Yeast   116 VAGPS----------SVGGAGVSTPHSTKINKPRKKKQCPICRNFYANLTTHKATHLTPEDR--- 167

  Fly   225 KGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQV 289
              |::|.:|.|.|...:.|:||.::|..|.|.||:.             |:..::.|
Yeast   168 --PHKCPICHRGFARNNDLLRHKKRHWKDEILSQSG-------------VLSNHNDG-------- 209

  Fly   290 AFRHGLIHDSEHST-MRQSPMTQVP-------------SNRADFNELLLDGEMLIDNDP------ 334
              :.|.:..::..| .:.:||..|.             :.:..||..|:..:|  |..|
Yeast   210 --KGGSVSPNDDDTHEKMTPMNSVTDYAQLKSLHQIKGTFKCPFNSTLIQLDM--DMYPYKLKPL 270

  Fly   335 AFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNT 399
            .|.|||.:    :..:||                                       .||...|.
Yeast   271 NFETSNCH----QTGVFS---------------------------------------RCDTFKNH 292

  Fly   400 AKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDL-LQEH 447
            .|  ::||:......:   :..||...|   |..|.|||.|.|: |.||
Yeast   293 LK--ALHFEYPPGTKK---KDRNVVPGR---CKHCGLKFENVDVWLNEH 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	2/19 (11%)
		C2H2 Zn finger	431..453	CDD:275368	10/18 (56%)
		COG5048	<450..647	CDD:227381
		C2H2 Zn finger	469..490	CDD:275368
		zf-C2H2	511..533	CDD:278523
		C2H2 Zn finger	513..564	CDD:275368
		C2H2 Zn finger	541..561	CDD:275368
		zf-H2C2_2	555..581	CDD:290200
		C2H2 Zn finger	572..592	CDD:275368
		zf-H2C2_2	585..609	CDD:290200
		zf-C2H2	598..620	CDD:278523
		C2H2 Zn finger	600..620	CDD:275368
		zf-H2C2_2	612..637	CDD:290200
		C2H2 Zn finger	628..646	CDD:275368
STP3	NP_013479.3	COG5048	<137..295	CDD:227381	40/232 (17%)
		C2H2 Zn finger	144..161	CDD:275368	2/16 (13%)
		C2H2 Zn finger	171..191	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100