DRSC/TRiP Functional Genomics Resources

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Protein Alignment topi and ZNF878

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:XP_016882684.1 Gene:ZNF878 / 729747 HGNCID:37246 Length:567 Species:Homo sapiens


Alignment Length:623 Identity:152/623 - (24%)
Similarity:234/623 - (37%) Gaps:170/623 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 FHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSK 186
            |.|....:...:.:.|...||.:..|:|||::       :.|...|:|...|.|:        .|
Human    13 FLGIGYRNPVLSASLILLSTCGIFQDSVAFED-------VAVNFTQEEWALLDPS--------QK 62

  Fly   187 PASERVIRENQVRL--------RRYIKDE-------MKYDLATGIESSRKNAAKG------PN-- 228
            .....|::|....|        .:||:||       ::..:...:..|:::...|      |:  
Human    63 NLYREVMQETLRNLTSIGKKWNNQYIEDEHQNPRRNLRRLIGERLSESKESHQHGEVLTQVPDDT 127

  Fly   229 -----------ECTMCD-------------RKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAA 269
                       |.::|.             |.|.::|.|..|...|        |.|:|:     
Human   128 LKKKTPGVQSYESSVCGEIGIGLSSLNRHLRAFSYSSSLAIHGRTH--------TGEKPY----- 179

  Fly   270 GLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRA-DFNELLLDGEMLIDND 333
                  :|..||:.|..|....||..||.:      :.|.......:| .|              
Human   180 ------ECKECGKAFRFPSSVRRHERIHSA------KKPYECKQCGKAFSF-------------- 218

  Fly   334 PAFATSNQNTNPPKKEMFSSLILGSVL-------------------QCEFCEYIFADIAELLVHS 379
            |:....::..:..||. :.....|..|                   :|..|...|...:.|..|.
Human   219 PSSVRRHERIHSAKKP-YECKQCGKALSYLVSFQTHMRMHTGERPHKCNICGKAFFSPSSLKRHE 282

  Fly   380 ASHVAERRFECTACDIQMNTAKEASIHFQT-------DCIFMREAIRSLNV--------TLSRYF 429
            .||..|:|::|..||...|.......|.:|       :|...|:|.||:..        |..:.:
Human   283 KSHTGEKRYKCKQCDKAFNCPSSFQYHERTHSGEKPYECTQCRKAFRSVKYLRVHERKHTGEKPY 347

  Fly   430 VCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKK 494
            .|.:|...|.::        |||.|..:.:...|.  ..|..|...|.|..|...| |..|..:|
Human   348 ECKLCGKGFISS--------TSFRYHEKTHTGEKP--YECKKCVKAFSFVKDLRIH-ERTHTGEK 401

  Fly   495 KRE----------------KETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQE 543
            ..|                .|..:||.   :.|.|..|||::..:|.|.:|:|.|.|.||:.|::
Human   402 PFECKQCGKTFTSSNSFHYHERTHTGE---KPYECKQCGKAFRSASVLQKHIRTHTGEKPYGCKQ 463

  Fly   544 ENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFY 608
              |.:.|.:...|..| .:.||||:||.|..|||.|::.:....|:..|.||:.|:|::|||.|.
Human   464 --CGKVFRVASQLKMH-ERTHTGEKPYECKQCGKAFISSNSIRYHKRTHTGEKPYKCKQCGKAFI 525

  Fly   609 RADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIR 646
            .:::...|:|||||||||.|..|.|.||......||:|
Human   526 SSNSFLYHERIHTGEKPYECKQCGKAFRSASILQKHVR 563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368 6/32 (19%)
C2H2 Zn finger 277..297 CDD:275368 7/19 (37%)
C2H2 Zn finger 431..453 CDD:275368 5/21 (24%)
COG5048 <450..647 CDD:227381 75/213 (35%)
C2H2 Zn finger 469..490 CDD:275368 7/20 (35%)
zf-C2H2 511..533 CDD:278523 9/21 (43%)
C2H2 Zn finger 513..564 CDD:275368 17/50 (34%)
C2H2 Zn finger 541..561 CDD:275368 5/19 (26%)
zf-H2C2_2 555..581 CDD:290200 13/25 (52%)
C2H2 Zn finger 572..592 CDD:275368 6/19 (32%)
zf-H2C2_2 585..609 CDD:290200 10/23 (43%)
zf-C2H2 598..620 CDD:278523 8/21 (38%)
C2H2 Zn finger 600..620 CDD:275368 7/19 (37%)
zf-H2C2_2 612..637 CDD:290200 14/24 (58%)
C2H2 Zn finger 628..646 CDD:275368 7/17 (41%)
ZNF878XP_016882684.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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