DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and Zfp74

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_848471.2	Gene:	Zfp74 / 72723	MGIID:	107784	Length:	679	Species:	Mus musculus

Alignment Length:	773	Identity:	190/773 - (24%)
Similarity:	276/773 - (35%)	Gaps:	227/773 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GEYTLAEIEVELDQ----QLTPDDLQPGATVLATNESTGGLERIVSHEELSRFFAVGPAGALPMP 67
            |..|..::.::..|    ||.|              :...|.|.|..|..:....|||  .|..|
Mouse     6 GLVTFKDVAIDFTQEEWKQLDP--------------TQRNLYRNVMLENYNNLITVGP--PLTKP 54

  Fly    68 TDV----------VVER-TLADPAFKQILQEADGKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSV 121
            ..:          |||| .|..|...:||       |.|   |..||:|             ..|
Mouse    55 EVIFKLEQEEEPCVVEREVLWRPCPGEIL-------GID---EHQKIQD-------------GQV 96

  Fly   122 FHGSRSNSSASTVNRIKCPTCLVQFDAVAFQN-------HS---CEA-----KP------IEVAV 165
            |.|....|.||     :||.   :|.:..|.|       ||   |:.     :|      ::..:
Mouse    97 FEGIVVTSEAS-----ECPE---EFASTFFPNADSIPSMHSLFECDGVGECLEPNFGDDDVQYPL 153

  Fly   166 PQQE-------------KPHLVPTVSAPPAPL-----SKPASERVIRENQVRLRRYIKDEMKYDL 212
            |:::             .||.|.|      |.     .|..|:.:.....:|:....|....:..
Mouse   154 PEEQFEYDDAMQPFHTSSPHFVLT------PFKCNHCGKGFSQTLDLIRHLRVHTGGKLYECHQC 212

  Fly   213 ATGIESSRK-------NAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAG 270
            ..|.....|       ::.:...||:.|.:.|:..|.|:||...|        |.|:|:.....|
Mouse   213 GKGFSHKEKLINHHKLHSREQCYECSECGKTFIKMSNLIRHQRIH--------TGEKPYVCQECG 269

  Fly   271 --------------LHV---VVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRAD 318
                          :|.   ..|||.||:.|...|....|..:|..|      .|.......:|
Mouse   270 KSFGQKSNLIDHEKIHTGEKPYKCNECGKSFSQKQSLVAHQKVHTGE------KPYACNECGKA- 327

  Fly   319 FNELLLDGEMLIDNDPAFAT------SNQNTNPPKKE-------MFSSLIL-------GSVLQCE 363
                          .|..|:      .:....|.|.:       .||.||:       ....:|.
Mouse   328 --------------FPRVASLALHMRGHTGEKPYKCDKCGKAFSQFSMLIIHVRVHTGEKPYECG 378

  Fly   364 FCEYIFADIAELLVHSASHVAERRFECTAC----DIQMNTAKEASIHFQ------TDC----IFM 414
            .|...|:..:.|.||..||..|:.:||..|    ..:.|......||.:      .:|    |.|
Mouse   379 ECGKAFSQSSALTVHIRSHTGEKPYECKECRKSFSHKKNFITHQKIHTREKPYGCNECGKAFIQM 443

  Fly   415 REAIRSLNV-TLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLP--CDFCDVNF 476
            ...:|...: |..:.::|..|...|:....|..|.  ..|       :|:|   |  |:.|...|
Mouse   444 SNLVRHQRIHTGEKPYLCKECGKAFSQKSNLIAHE--KIH-------SGEK---PYECNECGKAF 496

  Fly   477 EFAHDFLAHSEEKHLNKKKREKETRNTGAGRI-------------RQYLCDICGKSYTQSSHLWQ 528
            ....:|:.| ::.|..:|..:.........:|             :.|.|:.|||:::|.|.|..
Mouse   497 SQKQNFITH-QKVHTGEKPYDCNKCGKAFSQIASLTLHLRSHTGEKPYECEKCGKAFSQCSLLNL 560

  Fly   529 HLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHR 593
            |:|.|.|.||:||.|  |.:.|:.|..|..|:|. ||||:||.|..|||.|...|....|...|.
Mouse   561 HMRSHTGEKPYVCNE--CGKAFSQRTSLIVHMRG-HTGEKPYECNKCGKAFSQSSSLTIHIRGHT 622

  Fly   594 GERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSH 651
            ||:.::|..|||.|.:..:|..|.|.|||||||.|:.|.|.|.|:....:|.|. |:|
Mouse   623 GEKPFDCSNCGKAFSQISSLTLHMRKHTGEKPYVCIECGKAFSQKSHLVRHQRI-HTH 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	72/211 (34%)
		C2H2 Zn finger	469..490	CDD:275368	5/20 (25%)
		zf-C2H2	511..533	CDD:278523	10/21 (48%)
		C2H2 Zn finger	513..564	CDD:275368	22/50 (44%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	14/25 (56%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	9/23 (39%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:290200	14/24 (58%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
Zfp74	NP_848471.2	KRAB	8..68	CDD:214630	14/75 (19%)
		C2H2 Zn finger	181..201	CDD:275368	3/19 (16%)
		COG5048	205..638	CDD:227381	118/477 (25%)
		C2H2 Zn finger	209..229	CDD:275368	2/19 (11%)
		C2H2 Zn finger	237..257	CDD:275368	7/19 (37%)
		C2H2 Zn finger	265..285	CDD:275368	1/19 (5%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
		C2H2 Zn finger	321..341	CDD:275368	3/34 (9%)
		C2H2 Zn finger	349..369	CDD:275368	4/19 (21%)
		C2H2 Zn finger	377..397	CDD:275368	6/19 (32%)
		C2H2 Zn finger	405..425	CDD:275368	3/19 (16%)
		C2H2 Zn finger	433..453	CDD:275368	4/19 (21%)
		C2H2 Zn finger	461..481	CDD:275368	5/21 (24%)
		C2H2 Zn finger	489..509	CDD:275368	5/20 (25%)
		C2H2 Zn finger	517..537	CDD:275368	1/19 (5%)
		C2H2 Zn finger	545..565	CDD:275368	9/19 (47%)
		C2H2 Zn finger	573..593	CDD:275368	8/22 (36%)
		C2H2 Zn finger	601..621	CDD:275368	7/19 (37%)
		C2H2 Zn finger	629..649	CDD:275368	8/19 (42%)
		zf-H2C2_2	641..666	CDD:372612	14/24 (58%)
		C2H2 Zn finger	657..677	CDD:275368	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910