DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and CG1792

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_651878.1	Gene:	CG1792 / 43727	FlyBaseID:	FBgn0039860	Length:	372	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	85/346 - (24%)
Similarity:	133/346 - (38%)	Gaps:	78/346 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 FECTACDIQMNTA---KEASIHFQTDCIFMREAIRSLNVTLSRYFVCNV-CELKFAN-------T 441
            |.|:.|::.:.||   :|..|..|..   ::|:....|..|...|...| .|:::|.       .
  Fly    52 FICSPCELDLQTAIAFRERVIRTQKT---LQESPNLGNAELIESFAVGVEKEIQYAEEVTEIEVI 113

  Fly   442 DLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKET------ 500
            |||.|.     |......|       |.:.|:.|.:  ......::||.|.:..:...|
  Fly   114 DLLPEE-----HLLEETEE-------PYEICEQNEQ--PQVKVPAQEKKLRRSTKTTPTVFTSVK 164

  Fly   501 --RNTGAGRI-------------------RQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEE 544
              .|:.|.|.                   |..:|:.||:.:|..|:...||..|.|||.|.|  :
  Fly   165 FADNSQATRTQWSRLTEDEVVALKRERRKRDCICEQCGRHFTCPSNFKLHLLRHTGVKSFAC--D 227

  Fly   545 NCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQH-RLIHRGERRYECEECGKRFY 608
            .|.::|.....|..| ::.|.|...:.|..|...:...|...|| |:.|...:.:.|:||.|.|.
  Fly   228 QCSQQFYTATLLRRH-QELHAGNALFQCRYCEATYSNASGRIQHERMRHTNVKPFTCKECNKSFA 291

  Fly   609 RADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRAR-HSHLDANSRLMMQMQKFQLETAAA 672
            .:..|:.|...|||.:.:.|..|..:|.:|.....|.|:: |:|                 |::|
  Fly   292 MSGKLRTHMLSHTGVRAFHCDSCQVSFVRRSHLTSHYRSKGHAH-----------------TSSA 339

  Fly   673 QKAQSHNPEQQDNDVAGGAST 693
            |.|.. ||.:.|...:.|..|
  Fly   340 QAALD-NPVELDVKASNGMQT 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	431..453	CDD:275368	7/29 (24%)
		COG5048	<450..647	CDD:227381	54/224 (24%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		zf-C2H2	511..533	CDD:278523	7/21 (33%)
		C2H2 Zn finger	513..564	CDD:275368	17/50 (34%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		zf-H2C2_2	555..581	CDD:290200	6/25 (24%)
		C2H2 Zn finger	572..592	CDD:275368	6/20 (30%)
		zf-H2C2_2	585..609	CDD:290200	9/24 (38%)
		zf-C2H2	598..620	CDD:278523	7/21 (33%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	8/24 (33%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
CG1792	NP_651878.1	zf-AD	6..80	CDD:214871	8/30 (27%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		C2H2 Zn finger	226..243	CDD:275368	5/19 (26%)
		C2H2 Zn finger	254..275	CDD:275368	6/20 (30%)
		zf-C2H2	281..303	CDD:278523	7/21 (33%)
		C2H2 Zn finger	283..303	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..320	CDD:290200	8/23 (35%)
		C2H2 Zn finger	311..329	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910