Protein Alignment topi and CG17806

DIOPT Version :10

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_650658.1
• Gene: CG17806 / 42142
• FlyBaseID: FBgn0038548
• Length: 421
• Species: Drosophila melanogaster
• Alignment Length: 603
• Identity: 134/603 - (22%)
• Similarity: 197/603 - (32%)
• Gaps: 230/603 - (38%)

  Fly    86 QEADGKKG-FDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQF-DA 148
            |||:..|. ||.:|     ||.|:.:.  |:|       |....:......|| |.:||:.. ||
  Fly    10 QEAEHAKSLFDKEA-----RDVLSNIL--KLT-------GFWLRNQPGVPTRI-CLSCLLDLNDA 59

  Fly   149 VAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLA 213
            :||:                                     ||.||.|.....:..|.|
  Fly    60 IAFR-------------------------------------ERCIRTNSSWFEKQGKQE------ 81

  Fly   214 TGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHAL-------DLIPSQTSEQP------HT 265
               :|..:.|.:|.|. .:..|..|....:.:...:..|       |.:|.:|.|.|      ..
  Fly    82 ---DSDTETAREGGNN-RLESRVDVMPISIAQPQRRRILPQRSKKVDGVPLKTVETPIYPLVVPE 142

  Fly   266 IPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLI 330
            ||.|.|...::|....::..:||::..:.:     .|...:.|.:::|
  Fly   143 IPPADLVDPLRCEDPIQVKSEPQLSSDYPV-----ESMNHEEPASEMP----------------- 185

  Fly   331 DNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDI 395
                         ...|:|..:..::|                                    ::
  Fly   186 -------------QVMKEEPRTLQVIG------------------------------------EV 201

  Fly   396 QMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNE 460
            |.|..|                                                      ||
  Fly   202 QKNRRK------------------------------------------------------PR--- 209

  Fly   461 NGKKLLLPCDFCDVNFEFAHDFLAHSE--EKHLNKKKREK-ETRNT-GAGR------IRQYLCDI 515
             .|..|..|...|         :|..|  :...||.|.|| .|||. ||.:      .|.|.||.
  Fly   210 -SKGCLEECPGKD---------MAKIENIDSTTNKTKEEKYATRNKWGAAKRAYALEHRLYFCDQ 264

  Fly   516 CGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFL 580
            |||::::..:...|||.|:|.|.|.|||  |||....:..||.|:|..|.||.||:|..|||||.
  Fly   265 CGKTFSEKGNFNVHLRRHKGTKEFQCQE--CDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFD 327

  Fly   581 TGSVFYQHRLIHRG---ERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRD 642
            .......|...|:.   .|.:.|..|.|.|..:.|||:|..:||||:|:.|..|...|.:|....
  Fly   328 NCLKRLNHERNHKESPVHRPHVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTFFNRRNALA 392

  Fly   643 KHIRARHSHLDANSRLMM 660
            .|.:::|..|....:..|
  Fly   393 THYKSKHHRLKVEEQSKM 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	2/19 (11%)
		C2H2 Zn finger	277..297	CDD:275370	3/19 (16%)
		C2H2 Zn finger	431..453	CDD:275368	0/21 (0%)
		COG5048	<450..647	CDD:227381	74/209 (35%)
		C2H2 Zn finger	469..490	CDD:275368	4/22 (18%)
		C2H2 Zn finger	513..564	CDD:275368	22/50 (44%)
		C2H2 Zn finger	541..561	CDD:275368	9/19 (47%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:463886	12/24 (50%)
		C2H2 Zn finger	628..646	CDD:275368	5/17 (29%)
CG17806	NP_650658.1	zf-AD	4..75	CDD:462262	27/116 (23%)
		zf-C2H2	260..282	CDD:395048	9/21 (43%)
		C2H2 Zn finger	262..282	CDD:275368	8/19 (42%)
		C2H2 Zn finger	290..311	CDD:275368	10/22 (45%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		ZnF_U1	375..407	CDD:197732	8/31 (26%)
		C2H2 Zn finger	378..396	CDD:275368	5/17 (29%)