Protein Alignment topi and MAZ

DIOPT Version :10

• Sequence 1: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_001036004.1
• Gene: MAZ / 4150
• HGNCID: 6914
• Length: 493
• Species: Homo sapiens
• Alignment Length: 680
• Identity: 128/680 - (18%)
• Similarity: 198/680 - (29%)
• Gaps: 265/680 - (38%)

  Fly    47 VSHEELSRFF-----AVGPAGALPMPTDVVVERTLADPAFKQILQEADGKKGFDPQAEQMKIRDF 106
            |..|..||||     |..|..|.|.|           |...|.           |.||.::: |.
Human    44 VGAELQSRFFASQGCAQSPFQAAPAP-----------PPTPQA-----------PAAEPLQV-DL 85

  Fly   107 LAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKP 171
            |..:.:::   |.:....:.:.::|:.......|......|..|.:.......|
Human    86 LPVLAAAQ---ESAAAAAAAAAAAAAVAAAPPAPAAASTVDTAALKQPPAPPPP----------- 136

  Fly   172 HLVPTVSAPPAPLSKPASERVIR----------ENQVRLRRYIKDEMKYDLATGIESSRKNAAKG 226
              .|.||||.|..:.|||...|.          .:.|.:.         .:|:.:|  :|..:||
Human   137 --PPPVSAPAAEAAPPASAATIAAAAATAVVAPTSTVAVA---------PVASALE--KKTKSKG 188

  Fly   227 PNECTMCDRKFVHASGLVRHMEKHA---LDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQ 288
            |..|.:|.::|.:...|.||...|.   ...:||...:.|..:|.:.|.|             ||
Human   189 PYICALCAKEFKNGYNLRRHEAIHTGAKAGRVPSGAMKMPTMVPLSLLSV-------------PQ 240

  Fly   289 VAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSS 353
            ::...|                  ....|...    .|...:.......|:.......|..
Human   241 LSGAGG------------------GGGEAGAG----GGAAAVAAGGVVTTTASGKRIRKNH---- 279

  Fly   354 LILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAI 418
                   .||.|...|.|:..|..|..||..|:.::|.
Human   280 -------ACEMCGKAFRDVYHLNRHKLSHSDEKPYQCP--------------------------- 310

  Fly   419 RSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFL 483
                          ||:.:|...|.:      |:|.                       .:||..
Human   311 --------------VCQQRFKRKDRM------SYHV-----------------------RSHDGA 332

  Fly   484 AHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDR 548
            .|                       :.|.|..||||:::..|
Human   333 VH-----------------------KPYNCSHCGKSFSRPDH----------------------- 351

  Fly   549 KFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADAL 613
                   ||.|:|:.|:.|||:.|..|...|.|......|.:.|  |.:..|..|||....| .:
Human   352 -------LNSHVRQVHSTERPFKCEKCEAAFATKDRLRAHTVRH--EEKVPCHVCGKMLSSA-YI 406

  Fly   614 KNHQRIHTGEKPYSCLFCTKTF------RQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAA- 671
            .:|.::|:....:.|..|.|.|      |....:|..::|..:     .|::.::.....:|.|
Human   407 SDHMKVHSQGPHHVCELCNKGFTTAAYLRIHAVKDHGLQAPRA-----DRILCKLCSVHCKTPAQ 466

  Fly   672 -AQKAQSHNPEQQDNDVAGGAS---TSDVP 697
             |...|:|         .|||:   ..|.|
Human   467 LAGHMQTH---------LGGAAPPVPGDAP 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275370	3/19 (16%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	40/202 (20%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		C2H2 Zn finger	513..564	CDD:275368	10/50 (20%)
		C2H2 Zn finger	541..561	CDD:275368	3/19 (16%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	612..637	CDD:463886	6/30 (20%)
		C2H2 Zn finger	628..646	CDD:275368	6/23 (26%)
MAZ	NP_001036004.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..78		8/40 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..146		8/37 (22%)
		C2H2 Zn finger	192..212	CDD:275368	6/19 (32%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		SFP1	<303..360	CDD:227516	22/179 (12%)
		C2H2 Zn finger	309..329	CDD:275368	7/89 (8%)
		C2H2 Zn finger	339..357	CDD:275368	9/47 (19%)
		C2H2 Zn finger	368..388	CDD:275368	5/19 (26%)
		C2H2 Zn finger	394..413	CDD:275368	6/19 (32%)
		KREPA	<400..>451	CDD:483960	10/56 (18%)
		C2H2 Zn finger	421..437	CDD:275368	5/15 (33%)
		C2H2 Zn finger	454..474	CDD:275368	4/19 (21%)