DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and ZNF728

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001254645.1	Gene:	ZNF728 / 388523	HGNCID:	32463	Length:	622	Species:	Homo sapiens

Alignment Length:	570	Identity:	138/570 - (24%)
Similarity:	193/570 - (33%)	Gaps:	196/570 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 HGSRSN-SSASTVNRI-------KCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSA 179
            ||...| |||.|..||       ||..|     ..||...|...|
Human   206 HGKAFNWSSALTYKRIHTGEKPCKCEEC-----GKAFSKFSILTK-------------------- 245

  Fly   180 PPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATG---IESSRKNAAKGPNECTMCDRKFVHAS 241
                      .:||...:   :.|..:|........   ||..|.:|.:.|.:|..|.:.|..||
Human   246 ----------HKVIHTGE---KHYKCEECGKAFTRSSSLIEHKRSHAGEKPYKCEECGKAFSKAS 297

  Fly   242 GLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQ 306
            .|..|...||        .|:|:           ||..||:.|........|..||..|
Human   298 TLTAHKTIHA--------GEKPY-----------KCEECGKAFNRSSNLMEHKRIHTGE------ 337

  Fly   307 SPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFAD 371
                                                 .|.|              ||.|...|.:
Human   338 -------------------------------------KPCK--------------CEECGKAFGN 351

  Fly   372 IAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCEL 436
            .:.|..|...|..|:.::|..|....:.....:.|            :.::.. .:.:.|..|..
Human   352 FSTLTKHKVIHTGEKPYKCEECGKAFSWPSSLTEH------------KRIHAG-DKPYKCEECGK 403

  Fly   437 KFANTDLLQEHRCTSFHYFPRLNENGKKLLLP--CDFCDVNF----EFAHDFLAHSEEKHLNKKK 495
            .|..:..|.:|         ::...|:|   |  |:.|...|    ......:.|:.|||
Human   404 TFKWSSTLTKH---------KIIHTGEK---PYKCEECGKAFTTFSSLTKHKVIHTGEKH----- 451

  Fly   496 REKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHI 560
                           |.|:.|||.::.||.|..|...|.|.|.:.|:|  |.:.|....:|.:|
Human   452 ---------------YKCEECGKVFSWSSSLTTHKAIHAGEKLYKCEE--CGKAFKWSSNLMEH- 498

  Fly   561 RKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKP 625
            ::.||||:||.|..|||.|...:...:|::||.||::|:||||||.|..:..|..|:||||||||
Human   499 KRIHTGEKPYKCEECGKAFSKVANLTKHKVIHTGEKQYKCEECGKAFIWSSRLSEHKRIHTGEKP 563

  Fly   626 YSCLFCTKTFRQRGDRDKH--IRA---------------RHSHLDANSRL 658
            |.|..|.|.|......:||  |.|               :.|||..:.|:
Human   564 YKCEECGKAFSWVSVLNKHKKIHAGKKFYKCEECGKDFNQSSHLTTHKRI 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	431..453	CDD:275368	5/21 (24%)
		COG5048	<450..647	CDD:227381	70/204 (34%)
		C2H2 Zn finger	469..490	CDD:275368	5/24 (21%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	17/50 (34%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	13/25 (52%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	13/23 (57%)
		zf-C2H2	598..620	CDD:278523	11/21 (52%)
		C2H2 Zn finger	600..620	CDD:275368	10/19 (53%)
		zf-H2C2_2	612..637	CDD:290200	15/24 (63%)
		C2H2 Zn finger	628..646	CDD:275368	6/19 (32%)
ZNF728	NP_001254645.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	146..167	CDD:275370
		C2H2 Zn finger	175..195	CDD:275368
		COG5048	186..583	CDD:227381	131/538 (24%)
		C2H2 Zn finger	230..250	CDD:275368	7/54 (13%)
		C2H2 Zn finger	258..278	CDD:275368	4/19 (21%)
		C2H2 Zn finger	286..306	CDD:275368	7/19 (37%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		zf-H2C2_2	326..349	CDD:290200	9/79 (11%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		zf-H2C2_2	355..378	CDD:290200	6/22 (27%)
		C2H2 Zn finger	370..390	CDD:275368	3/31 (10%)
		zf-H2C2_2	382..406	CDD:290200	3/36 (8%)
		C2H2 Zn finger	398..418	CDD:275368	5/28 (18%)
		zf-H2C2_2	411..435	CDD:290200	8/35 (23%)
		C2H2 Zn finger	426..446	CDD:275368	3/19 (16%)
		C2H2 Zn finger	454..474	CDD:275368	8/19 (42%)
		C2H2 Zn finger	482..502	CDD:275368	6/22 (27%)
		zf-H2C2_2	494..518	CDD:290200	12/24 (50%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
		zf-H2C2_2	522..545	CDD:290200	12/22 (55%)
		C2H2 Zn finger	538..558	CDD:275368	10/19 (53%)
		zf-H2C2_2	551..574	CDD:290200	14/22 (64%)
		C2H2 Zn finger	566..586	CDD:275368	6/19 (32%)
		C2H2 Zn finger	594..614	CDD:275368	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910