DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and hic2

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_878289.2	Gene:	hic2 / 359828	ZFINID:	ZDB-GENE-030619-1	Length:	560	Species:	Danio rerio

Alignment Length:	525	Identity:	107/525 - (20%)
Similarity:	178/525 - (33%)	Gaps:	196/525 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 AGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPH 172
            :|.|:::..:..|:...|..::|.||.|.       ..||......:....:|:|:.|.:.|:
Zfish   218 SGSTATEEVSPSSIPQESPQSASESTANS-------ASFDENPNTQNLTAGEPMELGVGECEE-- 273

  Fly   173 LVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKF 237
                 |.||..:.:..|.|.:    .|.||..|.|.|               ||.:
Zfish   274 -----SQPPPDVDQHKSSRQV----TRQRRQPKSEGK---------------KGED--------- 305

  Fly   238 VHASGLVRHMEKHALDLIPSQTSEQ----PHTIPAAGLHVVVKCNSCGRIFYDPQVAFR-----H 293
                     ||:..|   |:..|::    ...:||.|     ..||        :|:|:     .
Zfish   306 ---------MERVTL---PNGVSKRLKVAGERLPAGG-----NGNS--------EVSFQCKDEEE 345

  Fly   294 GLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGS 358
            ||.:..|.|  .:|..::....|...|.:.                       ::|.|...:..:
Zfish   346 GLENGQEQS--EESGQSENEGGRNSANYVY-----------------------RQEGFEPALGDN 385

  Fly   359 VLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTA--KEASIHFQTDCIFMREAIRSL 421
            :..|..|...|....||..|..:|..|..:    ...:.|.:  ||..:..:.    :...|..:
Zfish   386 LYVCIPCGKGFPSSEELNAHVETHTEEELY----IKEEDNDSYPKEDEVEAED----LSSQITQV 442

  Fly   422 NVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHS 486
            :.|.:|.|.|:||...:.:...|::|..|  |:.
Zfish   443 HGTETRRFSCSVCNKSYKDPATLRQHEKT--HWL------------------------------- 474

  Fly   487 EEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFT 551
                                 .|.:.|:||||.:||...:.:|:|.|.|:|||.|:|  |..:||
Zfish   475 ---------------------TRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACEE--CGMRFT 516

  Fly   552 IRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNH 616
            .:..|.:|:|                             :|.||:.|||:.||.:|.:...|.:|
Zfish   517 RQYRLTEHMR-----------------------------VHSGEKPYECQLCGGKFTQQRNLISH 552

  Fly   617 QRIHT 621
            .|:||
Zfish   553 LRMHT 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	2/19 (11%)
		C2H2 Zn finger	277..297	CDD:275368	6/24 (25%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	39/172 (23%)
		C2H2 Zn finger	469..490	CDD:275368	0/20 (0%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	22/50 (44%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		zf-H2C2_2	555..581	CDD:290200	3/25 (12%)
		C2H2 Zn finger	572..592	CDD:275368	0/19 (0%)
		zf-H2C2_2	585..609	CDD:290200	9/23 (39%)
		zf-C2H2	598..620	CDD:278523	9/21 (43%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	5/10 (50%)
		C2H2 Zn finger	628..646	CDD:275368
hic2	NP_878289.2	BTB	18..118	CDD:279045
		BTB	25..120	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..163
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..367		44/217 (20%)
		C2H2 Zn finger	389..409	CDD:275368	6/19 (32%)
		zf-C2H2	450..472	CDD:278523	7/23 (30%)
		C2H2 Zn finger	452..472	CDD:275368	6/21 (29%)
		zf-C2H2	478..500	CDD:278523	9/21 (43%)
		C2H2 Zn finger	480..500	CDD:275368	9/19 (47%)
		zf-H2C2_2	493..517	CDD:290200	11/25 (44%)
		C2H2 Zn finger	508..528	CDD:275368	8/50 (16%)
		zf-H2C2_2	521..545	CDD:290200	12/52 (23%)
		C2H2 Zn finger	536..556	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910