DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and ZNF311

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_005249076.1	Gene:	ZNF311 / 282890	HGNCID:	13847	Length:	699	Species:	Homo sapiens

Alignment Length:	605	Identity:	152/605 - (25%)
Similarity:	231/605 - (38%)	Gaps:	181/605 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 DPAFKQI-LQEADGKKGFDPQAEQMKIRDFLAG---VTSSKMTTEQSVFHGSRSNSSASTVNRI- 137
            ||..::: :|:...:..::....: |:|:...|   ||..|...::.:......||..|..|::
Human   211 DPKVREVCVQDVKLENQWETSIRE-KLREEKEGSEEVTCKKGKNQKVLSKNLNPNSKHSQCNKVL 274

  Fly   138 ------KCPTCLVQFDAVAFQNHSCEAKPIEVAVPQQ----EKPHLVPTVSAPPAPLSKPASERV 192
                  :|..|     ...|..||      ::.:.:|    ||||           :.....:..
Human   275 IAQKLHECARC-----GKNFSWHS------DLILHEQIHSGEKPH-----------VCNECGKAF 317

  Fly   193 IRENQVRLRRYIKDEMKYDLATGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPS 257
            ...||:.:.|.|                 :..:.|..||.|.:.|...|.|.||.:.|
Human   318 KTRNQLSMHRII-----------------HTGEKPFNCTQCGKAFNSRSALCRHKKTH------- 358

  Fly   258 QTSEQPHTIPAAG----------LHVVV-------KCNSCGRIFYDPQVAFRHGL-IHDSEHSTM 304
             :.|:||.....|          :|.::       |||.||:.|     .|:|.| ||...|:
Human   359 -SGEKPHECRDCGKAFKTRNRLCMHQLIHTGEKPYKCNCCGKAF-----QFKHSLTIHGRIHT-- 415

  Fly   305 RQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIF 369
                                 ||                              ...:||.|...|
Human   416 ---------------------GE------------------------------KPYECEECGKAF 429

  Fly   370 ADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVC 434
            :..::|..|...|..||.:||:.|....:.:.:.|.|.:   |..||          :::.|..|
Human   430 SGSSDLTKHIRIHTGERPYECSKCGRAFSRSSDLSKHKR---IHTRE----------KHYGCPQC 481

  Fly   435 ELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKE 499
            ...|:....|.:||        |::...|:  ..|:.|...|            :| |.|:|..|
Human   482 GKDFSIKAELTKHR--------RIHTEEKR--YRCEECGKAF------------RH-NCKRRAHE 523

  Fly   500 TRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCH 564
            ..:||.   :.|.|..|||::.....|..|.|.|.|.||:.|.|  |.:.|:.:.:|.:| |:.|
Human   524 REHTGE---KPYQCRDCGKTFQDKHCLTIHQRIHTGEKPYKCLE--CGKAFSGKSNLTNH-RRIH 582

  Fly   565 TGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCL 629
            |||:|:.|.|||..|...||..||:.||.||:.|.|.|||..|.:..||..|:|:|||||||.|.
Human   583 TGEKPHKCEVCGMAFHHSSVLRQHKRIHTGEKPYTCSECGTSFRQGSALIGHKRVHTGEKPYECE 647

  Fly   630 FCTKTFRQRGDRDKHIRARH 649
            .|.|.||...:...|.:.:|
Human   648 ECGKAFRVSSNLTGHKKRKH 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	8/20 (40%)
		C2H2 Zn finger	431..453	CDD:275368	6/21 (29%)
		COG5048	<450..647	CDD:227381	72/196 (37%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		zf-C2H2	511..533	CDD:278523	8/21 (38%)
		C2H2 Zn finger	513..564	CDD:275368	18/50 (36%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	13/25 (52%)
		C2H2 Zn finger	572..592	CDD:275368	9/19 (47%)
		zf-H2C2_2	585..609	CDD:290200	12/23 (52%)
		zf-C2H2	598..620	CDD:278523	10/21 (48%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	15/24 (63%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
ZNF311	XP_005249076.1	KRAB	97..157	CDD:214630
		KRAB	97..136	CDD:279668
		C2H2 Zn finger	282..302	CDD:275368	6/30 (20%)
		zf-H2C2_2	294..319	CDD:290200	5/35 (14%)
		COG5048	306..>633	CDD:227381	116/462 (25%)
		C2H2 Zn finger	310..330	CDD:275368	4/36 (11%)
		zf-H2C2_2	323..347	CDD:290200	7/40 (18%)
		C2H2 Zn finger	338..358	CDD:275368	8/19 (42%)
		zf-H2C2_2	353..375	CDD:290200	7/29 (24%)
		C2H2 Zn finger	366..386	CDD:275368	2/19 (11%)
		C2H2 Zn finger	394..414	CDD:275368	10/24 (42%)
		zf-C2H2	420..442	CDD:278523	6/21 (29%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		zf-H2C2_2	434..459	CDD:290200	8/24 (33%)
		C2H2 Zn finger	450..470	CDD:275368	4/22 (18%)
		C2H2 Zn finger	478..498	CDD:275368	7/27 (26%)
		zf-H2C2_2	490..515	CDD:290200	8/46 (17%)
		C2H2 Zn finger	506..526	CDD:275368	8/32 (25%)
		zf-H2C2_2	520..541	CDD:290200	9/23 (39%)
		C2H2 Zn finger	534..554	CDD:275368	7/19 (37%)
		zf-H2C2_2	547..570	CDD:290200	10/24 (42%)
		C2H2 Zn finger	562..582	CDD:275368	7/22 (32%)
		zf-H2C2_2	574..599	CDD:290200	13/25 (52%)
		C2H2 Zn finger	590..610	CDD:275368	9/19 (47%)
		zf-H2C2_2	603..627	CDD:290200	12/23 (52%)
		C2H2 Zn finger	618..638	CDD:275368	9/19 (47%)
		zf-H2C2_2	634..653	CDD:290200	12/18 (67%)
		C2H2 Zn finger	646..664	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910