DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and Zfp53

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_038871.1	Gene:	Zfp53 / 24132	MGIID:	99200	Length:	652	Species:	Mus musculus

Alignment Length:	458	Identity:	123/458 - (26%)
Similarity:	173/458 - (37%)	Gaps:	135/458 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 RKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIF 284
            |.:..|.|.:|::|.:.|...:.|..|...|        |.|:|:           ||..||:.|
Mouse   246 RIHTGKKPYKCSVCGKSFTQCTNLKTHQRLH--------TGEKPY-----------KCKECGKSF 291

  Fly   285 YDPQVAF--RHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPK 347
              ||::.  .|..||..|.                                            |.
Mouse   292 --PQLSALKSHQKIHTGER--------------------------------------------PY 310

  Fly   348 KEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCI 412
            |             |:.|:..||..:....|..:|.||....|..|...::.......|::..
Mouse   311 K-------------CKECDKSFAHCSSFRRHQKTHRAEEHCSCPECGKVLHQLSHLRSHYRLH-- 360

  Fly   413 FMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCT-SFHYFPRLNENGKKLL---------- 466
                       |..:.:.||.|:..|......:.|:.| |...|.:..|.||..|
Mouse   361 -----------TGEKPYKCNECDRSFTYYASYRRHQKTHSLDKFYKCKECGKSFLELSHLKRHYR 414

  Fly   467 -------LPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSS 524
                   ..|:.||.:|.     :..:.:.||.....||           .:.|..|.||:|:.|
Mouse   415 IHTGEKPYKCEVCDKSFT-----VNSTLKTHLKIHTGEK-----------PFKCRECDKSFTKCS 463

  Fly   525 HLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHR 589
            ||.:|...|.|.||:.|:|  ||:.||....|..| :|.||||:||.|..|.|.|:..|....|:
Mouse   464 HLRRHQSVHTGEKPYRCKE--CDKSFTECSTLRAH-QKIHTGEKPYKCRECDKSFIQRSNLIIHQ 525

  Fly   590 LIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDA 654
            .:|.|||.|.|:||||.|.:...|:.||:||||||||.|:.|.|:|.|    |.|:|. |..:..
Mouse   526 RVHTGERPYICKECGKSFTKCSTLQIHQKIHTGEKPYKCMECNKSFTQ----DSHLRT-HQRVHT 585

  Fly   655 NSR 657
            ..|
Mouse   586 GER 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/21 (33%)
		C2H2 Zn finger	431..453	CDD:275368	7/22 (32%)
		COG5048	<450..647	CDD:227381	78/214 (36%)
		C2H2 Zn finger	469..490	CDD:275368	4/20 (20%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	22/50 (44%)
		C2H2 Zn finger	541..561	CDD:275368	8/19 (42%)
		zf-H2C2_2	555..581	CDD:290200	13/25 (52%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	12/23 (52%)
		zf-C2H2	598..620	CDD:278523	10/21 (48%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		zf-H2C2_2	612..637	CDD:290200	15/24 (63%)
		C2H2 Zn finger	628..646	CDD:275368	7/17 (41%)
Zfp53	NP_038871.1	KRAB	53..93	CDD:396083
		COG5048	223..627	CDD:227381	123/458 (27%)
		C2H2 Zn finger	228..248	CDD:275368	1/1 (100%)
		C2H2 Zn finger	256..276	CDD:275368	5/19 (26%)
		C2H2 Zn finger	284..304	CDD:275368	7/21 (33%)
		C2H2 Zn finger	312..332	CDD:275368	5/19 (26%)
		C2H2 Zn finger	340..360	CDD:275368	3/19 (16%)
		C2H2 Zn finger	370..388	CDD:275368	3/17 (18%)
		C2H2 Zn finger	396..416	CDD:275368	4/19 (21%)
		C2H2 Zn finger	424..444	CDD:275368	6/24 (25%)
		C2H2 Zn finger	452..472	CDD:275368	9/19 (47%)
		C2H2 Zn finger	480..500	CDD:275368	9/22 (41%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	536..556	CDD:275368	9/19 (47%)
		C2H2 Zn finger	564..584	CDD:275368	9/24 (38%)
		C2H2 Zn finger	592..612	CDD:275368
		C2H2 Zn finger	620..640	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910