DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment topi and ZXDB

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_009088.1	Gene:	ZXDB / 158586	HGNCID:	13199	Length:	803	Species:	Homo sapiens

Alignment Length:	825	Identity:	174/825 - (21%)
Similarity:	255/825 - (30%)	Gaps:	277/825 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PGATVLA--TNESTGGLERIVSHEELSRFFAV--GPAGALPMPTDVVVERTLADPAFKQILQEAD 89
            ||.::||  |::.:||     .......||.|  .|.|.   ..:.......|.|..::..:|..
Human    69 PGPSLLAPRTDQPSGG-----GGGGGDDFFLVLLDPVGG---DVETAGSGQAAGPVLREEAEEGP 125

  Fly    90 GKKGFDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNH 154
            |.:|.:..|..       ||.|:..                         |.||
Human   126 GLQGGESGANP-------AGPTALG-------------------------PRCL----------- 147

  Fly   155 SCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLATGIESS 219
                             ..|||    |||:|.|
Human   148 -----------------SAVPT----PAPISAP-------------------------------- 159

  Fly   220 RKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDL-IPSQTSEQPHTIPAAGLHVVVKCNSCGRI 283
                  || .........:|...|:...|...|.| .|...:.:|...||.....::.
Human   160 ------GP-AAAFAGTVTIHNQDLLLRFENGVLTLATPPPHAWEPGAAPAQQPGCLIA------- 210

  Fly   284 FYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNP--- 345
               ||..|.|. .|..:...:....:...|:..|                ||.|...:...|
Human   211 ---PQAGFPHA-AHPGDCPELPPDLLLAEPAEPA----------------PAPAPEEEAEGPAAA 255

  Fly   346 --PKKEMFS--SLILGSVLQCEFCEYIFADIAELLVHSASHVA---ERRFECT--ACDIQMNTAK 401
              |:..:.|  .::|....:.: |...||...:|.||..:|.:   :|.|:|.  .|.....|:.
Human   256 LGPRGPLGSGPGVVLYLCPEAQ-CGQTFAKKHQLKVHLLTHSSSQGQRPFKCPLGGCGWTFTTSY 319

  Fly   402 EASIHFQTDCIFMREAIRSLNVTLSRYFVCNV--CELKFANTDLLQEHRCTSFHYFPRLNENGKK 464
            :...|.|:     .:.:|.        |.|..  |...|.....|:.|  ...|.    .||..|
Human   320 KLKRHLQS-----HDKLRP--------FGCPAEGCGKSFTTVYNLKAH--MKGHE----QENSFK 365

  Fly   465 LLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDI--CGKSYTQSSHLW 527
                |:.|:.:|.......|| :..|...:              |.|.|..  |.|::...|.|:
Human   366 ----CEVCEESFPTQAKLSAH-QRSHFEPE--------------RPYQCAFSGCKKTFITVSALF 411

  Fly   528 QHLRFH-QGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLV--CGKRFLTGSVFYQHR 589
            .|.|.| :..:.|.|....|.:::.....|..|:|. ||||||:||..  ||..|.:.|...:|:
Human   412 SHNRAHFREQELFSCSFPGCSKQYDKACRLKIHLRS-HTGERPFLCDFDGCGWNFTSMSKLLRHK 475

  Fly   590 LIHRGERRYEC--EECGKRFYRADALKNHQRIHTGEKPYSC--------------LF-------- 630
            ..|..:||:.|  |.|||.|.||:.||.|...|.|.||:.|              |:
Human   476 RKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHLQ 540

  Fly   631 -------------CTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLETAAAQKAQSHNPEQ 682
                         |.|.|..:.....|:..||.        :.|....|||.|.:....|....|
Human   541 DVDTWKSRCPISSCNKLFTSKHSMKTHMVKRHK--------VGQDLLAQLEAANSLTPSSELTSQ 597

  Fly   683 QDNDVAGG---ASTSDVPS------------GSGFMSTE-PSVAEMQYSITPEQQEEMVCVPIDE 731
            :.||::..   :..||||.            .||.::.: .||:.......|......|...:|.
Human   598 RQNDLSDAEIVSLFSDVPDSTSAALLDTALVNSGILTIDVASVSSTLAGHLPANNNNSVGQAVDP 662

  Fly   732 VNNSFFMSHYMQAV---PMEEDGS---GQHIIVFEQPGQNMDMMS 770
            .:        :.|.   |...|.|   |.....|:|...|||.:|
Human   663 PS--------LMATSDPPQSLDTSLFFGTAATGFQQSSLNMDEVS 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	3/19 (16%)
		C2H2 Zn finger	277..297	CDD:275368	4/19 (21%)
		C2H2 Zn finger	431..453	CDD:275368	5/23 (22%)
		COG5048	<450..647	CDD:227381	63/238 (26%)
		C2H2 Zn finger	469..490	CDD:275368	5/20 (25%)
		zf-C2H2	511..533	CDD:278523	8/23 (35%)
		C2H2 Zn finger	513..564	CDD:275368	14/53 (26%)
		C2H2 Zn finger	541..561	CDD:275368	4/19 (21%)
		zf-H2C2_2	555..581	CDD:290200	14/27 (52%)
		C2H2 Zn finger	572..592	CDD:275368	6/21 (29%)
		zf-H2C2_2	585..609	CDD:290200	10/25 (40%)
		zf-C2H2	598..620	CDD:278523	11/23 (48%)
		C2H2 Zn finger	600..620	CDD:275368	11/21 (52%)
		zf-H2C2_2	612..637	CDD:290200	12/59 (20%)
		C2H2 Zn finger	628..646	CDD:275368	6/52 (12%)
ZXDB	NP_009088.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..140		6/26 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..260		8/58 (14%)
		Required for interaction with ZXDC. /evidence=ECO:0000250	271..577		86/353 (24%)
		C2H2 Zn finger	273..295	CDD:275368	6/22 (27%)
		zf-C2H2_aberr	304..449	CDD:293622	39/183 (21%)
		zf-C2H2	304..328	CDD:278523	6/28 (21%)
		C2H2 Zn finger	306..328	CDD:275368	5/26 (19%)
		C2H2 Zn finger	336..358	CDD:275368	5/23 (22%)
		zf-H2C2_2	350..373	CDD:290200	8/32 (25%)
		zf-C2H2	364..386	CDD:278523	6/26 (23%)
		C2H2 Zn finger	366..386	CDD:275368	5/20 (25%)
		C2H2 Zn finger	395..417	CDD:275368	7/21 (33%)
		C2H2 Zn finger	429..448	CDD:275368	4/19 (21%)
		COG5048	<441..572	CDD:227381	40/131 (31%)
		C2H2 Zn finger	456..478	CDD:275368	6/21 (29%)
		zf-H2C2_2	471..497	CDD:290200	10/25 (40%)
		C2H2 Zn finger	486..508	CDD:275368	11/21 (52%)
		C2H2 Zn finger	516..538	CDD:275370	2/21 (10%)
		Required for transcriptional activation. /evidence=ECO:0000250	576..703		31/132 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910