DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and Znf48

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_008758156.1	Gene:	Znf48 / 103690203	RGDID:	9115869	Length:	590	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	113/506 - (22%)
Similarity:	162/506 - (32%)	Gaps:	194/506 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 KGPNE----CTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIFY 285
            :|.|:    |..|.:.|...|.||:|...|        |.|:|:           ||..||:.|.
  Rat    76 QGSNDRAAVCGECGKSFRQMSDLVKHQRTH--------TGEKPY-----------KCGVCGKGFG 121

  Fly   286 DPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKKEM 350
            |.....:|...|..|      .|....|                    ||       ..|||...
  Rat   122 DSSARIKHQRTHTGE------KPYRVRP--------------------PA-------PGPPKMPR 153

  Fly   351 FSSLILGS-VLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQT----- 409
             |.:..|. ...|..|...|...::|:.|..:|..|:.::|..|......:.....|.:|
  Rat   154 -SRIPAGERPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCGICGKGFGDSSARIKHQRTHRGDQ 217

  Fly   410 ---DCIFMREAIRSLNVTLSR------YFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKL 465
               ..:..|:..::......|      .::|..|                           ||:.
  Rat   218 LPRPVVPRRQPSQAAPEATHRPKAQDKPYICTDC---------------------------GKRF 255

  Fly   466 LLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHL 530
            :|.|           ..|:| :..||..|               .:.||:|||.:.:.|.|.:||
  Rat   256 VLSC-----------SLLSH-QRSHLGPK---------------PFGCDVCGKEFARGSDLVKHL 293

  Fly   531 RFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIH--- 592
            |.|.|.||::|.|  |.:.|........|:| .|:|:||:.|..|.:.|...|...:|||.|
  Rat   294 RVHTGEKPYLCPE--CGKGFADSSARVKHLR-THSGQRPHACPECNRSFSLSSTLLRHRLTHMEP 355

  Fly   593 --------------------------------------------------------------RGE 595
                                                                          .|:
  Rat   356 QDFSFSAYPVAPLIPSPPPPPLGTSPSLTPRSPSQSSDGPFGLPGLEPEPGGPQAGEPPPPLAGD 420

  Fly   596 RRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIR 646
            :.::|.||||.|.|:..|..|.|:|||||||.|..|.|.|.....|.||:|
  Rat   421 KPHKCPECGKGFRRSSDLVKHHRVHTGEKPYLCPECGKGFADSSARVKHLR 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	431..453	CDD:275368	2/21 (10%)
		COG5048	<450..647	CDD:227381	67/262 (26%)
		C2H2 Zn finger	469..490	CDD:275368	3/20 (15%)
		zf-C2H2	511..533	CDD:278523	10/21 (48%)
		C2H2 Zn finger	513..564	CDD:275368	20/50 (40%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		zf-H2C2_2	555..581	CDD:290200	9/25 (36%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		zf-H2C2_2	585..609	CDD:290200	11/88 (13%)
		zf-C2H2	598..620	CDD:278523	10/21 (48%)
		C2H2 Zn finger	600..620	CDD:275368	10/19 (53%)
		zf-H2C2_2	612..637	CDD:290200	14/24 (58%)
		C2H2 Zn finger	628..646	CDD:275368	7/17 (41%)
Znf48	XP_008758156.1	zf-C2H2	84..105	CDD:278523	7/20 (35%)
		COG5048	85..471	CDD:227381	110/495 (22%)
		C2H2 Zn finger	85..105	CDD:275368	7/19 (37%)
		zf-H2C2_2	97..120	CDD:290200	11/41 (27%)
		C2H2 Zn finger	113..133	CDD:275368	6/19 (32%)
		C2H2 Zn finger	165..185	CDD:275368	5/19 (26%)
		zf-C2H2	165..185	CDD:278523	5/19 (26%)
		zf-H2C2_2	177..200	CDD:290200	6/22 (27%)
		C2H2 Zn finger	193..213	CDD:275368	3/19 (16%)
		C2H2 Zn finger	248..268	CDD:275368	8/58 (14%)
		C2H2 Zn finger	276..296	CDD:275368	10/19 (53%)
		zf-H2C2_2	288..312	CDD:290200	11/25 (44%)
		C2H2 Zn finger	304..324	CDD:275368	6/22 (27%)
		zf-H2C2_2	319..340	CDD:290200	8/21 (38%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		zf-C2H2	423..445	CDD:278523	10/21 (48%)
		C2H2 Zn finger	425..445	CDD:275368	10/19 (53%)
		zf-H2C2_2	437..461	CDD:290200	13/23 (57%)
		C2H2 Zn finger	453..537	CDD:275368	8/19 (42%)
		COG5048	495..>563	CDD:227381
		zf-C2H2	515..537	CDD:278523
		zf-H2C2_2	529..552	CDD:290200
		C2H2 Zn finger	545..565	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910