DRSC/TRiP Functional Genomics Resources

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Protein Alignment topi and LOC100496074

DIOPT Version :9

Sequence 1:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster
Sequence 2:XP_002938649.3 Gene:LOC100496074 / 100496074 -ID:- Length:385 Species:Xenopus tropicalis


Alignment Length:216 Identity:75/216 - (34%)
Similarity:99/216 - (45%) Gaps:21/216 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   481 DFLAHSEEKHLNKKKREKETRNTGAG--------------RIRQYLCDICGKSYTQSSHLWQHLR 531
            |....:|.|.:.|:...:..|:.|..              :.|.|:|.:||||:..:|.|.:|:|
 Frog   176 DIFEKNEPKSIPKEGPNESERDEGLACTNPVKMDQKPSVPKERLYICSVCGKSFGGNSLLVRHMR 240

  Fly   532 FHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGER 596
            .|.|.|||.|  .:||:.|..:..|..|:| .||||:||.|.||.|.|...|....|..||.|||
 Frog   241 IHTGEKPFAC--NHCDKSFNDKSYLLRHLR-THTGEKPYSCSVCLKCFSQNSSVIAHMRIHTGER 302

  Fly   597 RYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQ 661
            .::|.||.|||........|.|.|:|||||.|..|.|.|.|......|:|.   |..........
 Frog   303 PFQCPECEKRFSDKSYFVRHMRTHSGEKPYKCSHCEKCFSQTSSLTSHMRI---HTGEKPYKCSD 364

  Fly   662 MQK-FQLETAAAQKAQSHNPE 681
            ..| |...::.|...:.|.||
 Frog   365 CGKCFSQNSSLALHKRLHKPE 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275368
C2H2 Zn finger 277..297 CDD:275368
C2H2 Zn finger 431..453 CDD:275368
COG5048 <450..647 CDD:227381 67/179 (37%)
C2H2 Zn finger 469..490 CDD:275368 2/8 (25%)
zf-C2H2 511..533 CDD:278523 10/21 (48%)
C2H2 Zn finger 513..564 CDD:275368 21/50 (42%)
C2H2 Zn finger 541..561 CDD:275368 6/19 (32%)
zf-H2C2_2 555..581 CDD:290200 14/25 (56%)
C2H2 Zn finger 572..592 CDD:275368 7/19 (37%)
zf-H2C2_2 585..609 CDD:290200 12/23 (52%)
zf-C2H2 598..620 CDD:278523 8/21 (38%)
C2H2 Zn finger 600..620 CDD:275368 8/19 (42%)
zf-H2C2_2 612..637 CDD:290200 12/24 (50%)
C2H2 Zn finger 628..646 CDD:275368 6/17 (35%)
LOC100496074XP_002938649.3 KRAB 10..66 CDD:214630
COG5048 <203..373 CDD:227381 65/175 (37%)
C2H2 Zn finger 222..242 CDD:275368 9/19 (47%)
C2H2 Zn finger 250..270 CDD:275368 7/22 (32%)
C2H2 Zn finger 278..298 CDD:275368 7/19 (37%)
C2H2 Zn finger 306..326 CDD:275368 8/19 (42%)
C2H2 Zn finger 334..354 CDD:275368 7/22 (32%)
C2H2 Zn finger 362..382 CDD:275368 3/19 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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