DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment topi and LOC100125368

DIOPT Version :9

Sequence 1:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001132959.1	Gene:	LOC100125368 / 100125368	RGDID:	1642422	Length:	501	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	120/474 - (25%)
Similarity:	176/474 - (37%)	Gaps:	154/474 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 RKNAAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTSEQPHTIPAAGLHVVVKCNSCGRIF 284
            |.|..:.|.:|:.|.:.|.:...|.:|.:.|        |.|:|:           :|:.||:.|
  Rat    98 RINTEEKPYKCSQCSKAFANFRSLQKHEKNH--------TREKPY-----------ECSHCGKAF 143

  Fly   285 YDPQVAFRHGL-IHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQNTNPPKK 348
              |.   |..| ||:..|:                       ||...|
  Rat   144 --PS---RSSLQIHERTHT-----------------------GEKPFD----------------- 163

  Fly   349 EMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIHFQTDCIF 413
                         |..|...||..:.|.:|..:|..|:.::|..|....:|.....||
  Rat   164 -------------CSECGKAFARHSNLDIHKRTHTGEKPYDCNECGKAFSTRSHLQIH------- 208

  Fly   414 MREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKLLLP--CDFCDVNF 476
              |.:.    |..:.:|||.|...||....|:.|..|         ..|:|   |  |:.|. |.
  Rat   209 --EILH----TGEKPYVCNQCGKAFAYRSNLEAHDKT---------HTGEK---PYECNQCG-NA 254

  Fly   477 EFAHDFLAHSEEKHLNKK------------KREK----ETRNTGAGRIRQYLCDICGKSYTQSSH 525
            ..:...|.:.|:.|..:|            :|..    |..:||.   :.|:|:.|||::.:.|.
  Rat   255 YASRSSLRNHEKHHTGEKLYGCNECGRAFARRSSLEIHERTHTGE---KPYVCNQCGKAFARRSS 316

  Fly   526 LWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIR-------------------KC-------- 563
            |..|.|.|.|.||:.|.:  |.:.|..|..|.:|.:                   ||
  Rat   317 LQIHERTHTGEKPYGCNQ--CGKAFASRTSLQNHEKHHTGEKPYGCNQCGKAFELKCDLQIHERT 379

  Fly   564 HTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSC 628
            ||||:||.|..|||.|::......|...|..|:.|:|.:|||.|.....|:.|::.|||||||.|
  Rat   380 HTGEKPYRCNQCGKAFVSRRYLRNHEKHHTLEKLYDCSQCGKSFAIFRYLQKHKKTHTGEKPYKC 444

  Fly   629 LFCTKTFRQRGDRDKHIRA 647
            ..|.|.|..|.:..:|.|:
  Rat   445 THCGKAFAYRSNLYRHERS 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/20 (35%)
		C2H2 Zn finger	431..453	CDD:275368	8/21 (38%)
		COG5048	<450..647	CDD:227381	71/241 (29%)
		C2H2 Zn finger	469..490	CDD:275368	5/20 (25%)
		zf-C2H2	511..533	CDD:278523	9/21 (43%)
		C2H2 Zn finger	513..564	CDD:275368	20/77 (26%)
		C2H2 Zn finger	541..561	CDD:275368	6/19 (32%)
		zf-H2C2_2	555..581	CDD:290200	15/52 (29%)
		C2H2 Zn finger	572..592	CDD:275368	6/19 (32%)
		zf-H2C2_2	585..609	CDD:290200	9/23 (39%)
		zf-C2H2	598..620	CDD:278523	8/21 (38%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:290200	13/24 (54%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)
LOC100125368	NP_001132959.1	KRAB	4..>47	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	104..476	CDD:227381	118/468 (25%)
		C2H2 Zn finger	108..128	CDD:275368	5/19 (26%)
		zf-H2C2_2	120..143	CDD:290200	9/41 (22%)
		C2H2 Zn finger	136..156	CDD:275368	9/24 (38%)
		zf-H2C2_2	148..173	CDD:290200	10/77 (13%)
		C2H2 Zn finger	164..184	CDD:275368	6/19 (32%)
		zf-H2C2_2	176..201	CDD:290200	6/24 (25%)
		C2H2 Zn finger	192..212	CDD:275368	6/28 (21%)
		zf-H2C2_2	204..229	CDD:290200	9/37 (24%)
		C2H2 Zn finger	220..240	CDD:275368	8/28 (29%)
		C2H2 Zn finger	248..268	CDD:275368	5/20 (25%)
		C2H2 Zn finger	276..296	CDD:275368	2/19 (11%)
		zf-H2C2_2	288..313	CDD:290200	8/27 (30%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		C2H2 Zn finger	332..352	CDD:275368	6/21 (29%)
		C2H2 Zn finger	360..380	CDD:275368	2/19 (11%)
		zf-H2C2_2	372..397	CDD:290200	11/24 (46%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		zf-H2C2_2	428..453	CDD:290200	13/24 (54%)
		C2H2 Zn finger	444..464	CDD:275368	7/20 (35%)
		zf-H2C2_2	456..481	CDD:290200	2/8 (25%)
		C2H2 Zn finger	472..492	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910