Protein Alignment FoxP and FOXP3

DIOPT Version :9

• Sequence 1: NP_001247011.1
• Gene: FoxP / 41182
• FlyBaseID: FBgn0262477
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_016885056.1
• Gene: FOXP3 / 50943
• HGNCID: 6106
• Length: 473
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 122/476 - (25%)
• Similarity: 186/476 - (39%)
• Gaps: 153/476 - (32%)

  Fly    50 PPTGFLNNSITFASHVVKCS---SPASSIDESSTAAQQHESNPHMHIQGQHMMA------PVPDL 105
            |...|....:...:|....|   .|.|.:..|:..|  |...|.:.:......|      |....
Human    58 PGGTFQGRDLRGGAHASSSSLNPMPPSQLQLSTVDA--HARTPVLQVHPLESPAMISLTPPTTAT 120

  Fly   106 GFYNVP--------------EFISEQEKLMFSDAERFLRSKDNEVCNNDFSYMHDEFAMRKYYHP 156
            |.:::.              |::|.:..|:.:........||:.:.           |:.:..:|
Human   121 GVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKDSTLS-----------AVPQSSYP 174

  Fly   157 LFAHGICRWPGCEMDLEDITSFVKHLNTEHGLDDRSTAQARVQMQVVSQLESHLQKERDRLQAMM 221
            |.|:|:|:|||||...|:...|:||...:|.||::..||..:|.::|..||..|..|:::|.||.
Human   175 LLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQ 239

  Fly   222 HHLYLSKQLLSPTKIDRKDVPGREGKFCRSPLTVNSIGRPIRQTNSPSPL----NLPMVNSTNLC 282
            .||.....|...:.:...|    :|..|            |....|..|:    :.|.....:|.
Human   240 AHLAGKMALTKASSVASSD----KGSCC------------IVAAGSQGPVVPAWSGPREAPDSLF 288

  Fly   283 SIKKR---NHDKNTFSINGGLPYMLERAGLDVQQEIHRNREFYKNADVRPPFTYASLIRQAIIDS 344
            ::::.   :|..:||                  .|...|.:::|..::|||||||:|||.||:::
Human   289 AVRRHLWGSHGNSTF------------------PEFLHNMDYFKFHNMRPPFTYATLIRWAILEA 335

  Fly   345 PDKQLTLNEIYNWFQNTFCYFRRNAATWK------------------------------------ 373
            |:||.||||||:||...|.:||.:.||||
Human   336 PEKQRTLNEIYHWFTRMFAFFRNHPATWKVSSSEVAVTGMASSAIAAQSGQAWVWAHRHIGEERD 400

  Fly   374 ------------------------NAIRTNLSLHKCFVRYEDDFGSFWMVDDNEFVKRRHLSRGR 414
                                    ||||.||||||||||.|.:.|:.|.||:.||.|:|
Human   401 VGCWWWLLASEVDAHLLPVPGLPQNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKR------ 459

  Fly   415 PRKYEPSSSPNSCQSGNGVPT 435
                  |..|:.|.:    ||
Human   460 ------SQRPSRCSN----PT 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:292777	27/66 (41%)
		FH	328..400	CDD:238016	47/131 (36%)
FOXP3	XP_016885056.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5407
eggNOG	1	0.900	-	-		E2759_KOG4385
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	177	1.000	Inparanoid score	I4046
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.960