Protein Alignment FoxP and FOXP3

DIOPT Version :10

• Sequence 1: NP_001247011.1
• Gene: FoxP / 41182
• FlyBaseID: FBgn0262477
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_054728.2
• Gene: FOXP3 / 50943
• HGNCID: 6106
• Length: 431
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 109/331 - (32%)
• Similarity: 164/331 - (49%)
• Gaps: 68/331 - (20%)

  Fly   112 EFISEQEKLMFSDAERFLRSKDNEVCNNDFSYMHDEFAMRKYYHPLFAHGICRWPGCEMDLEDIT 176
            |::|.:..|:.:........||:.:.           |:.:..:||.|:|:|:|||||...|:..
Human   159 EWVSREPALLCTFPNPSAPRKDSTLS-----------AVPQSSYPLLANGVCKWPGCEKVFEEPE 212

  Fly   177 SFVKHLNTEHGLDDRSTAQARVQMQVVSQLESHLQKERDRLQAMMHHLYLSKQLLSPTKIDRKDV 241
            .|:||...:|.||::..||..:|.::|..||..|..|:::|.||..||.....|...:.:...|
Human   213 DFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSD- 276

  Fly   242 PGREGKFCRSPLTVNSIGRPIRQTNSPSPL----NLPMVNSTNLCSIKKR---NHDKNTFSINGG 299
               :|..|            |....|..|:    :.|.....:|.::::.   :|..:||
Human   277 ---KGSCC------------IVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTF----- 321

  Fly   300 LPYMLERAGLDVQQEIHRNREFYKNADVRPPFTYASLIRQAIIDSPDKQLTLNEIYNWFQNTFCY 364
                         .|...|.:::|..::|||||||:|||.||:::|:||.||||||:||...|.:
Human   322 -------------PEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAF 373

  Fly   365 FRRNAATWKNAIRTNLSLHKCFVRYEDDFGSFWMVDDNEFVKRRHLSRGRPRKYEPSSSPNSCQS 429
            ||.:.||||||||.||||||||||.|.:.|:.|.||:.||.|:|            |..|:.|.:
Human   374 FRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKR------------SQRPSRCSN 426

  Fly   430 GNGVPT 435
                ||
Human   427 ----PT 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:465036	27/66 (41%)
		FH_FOX	327..408	CDD:469596	52/80 (65%)
FOXP3	NP_054728.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..68
		Nuclear export signal. /evidence=ECO:0000269|PubMed:22678915	68..76
		LXXLL motif. /evidence=ECO:0000269|PubMed:18354202	92..96
		Interaction with ZFP90. /evidence=ECO:0000269|PubMed:23543754	106..198		9/49 (18%)
		Essential for transcriptional repressor activity and for interaction with KAT5 and HDAC7. /evidence=ECO:0000269|PubMed:17360565	106..190		6/41 (15%)
		Interaction with IKZF4. /evidence=ECO:0000250|UniProtKB:Q99JB6	149..199		10/50 (20%)
		FOXP-CC	193..260	CDD:465036	27/66 (41%)
		Leucine-zipper	239..260		8/20 (40%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:22678915	239..248		4/8 (50%)
		Interaction with RUNX1. /evidence=ECO:0000269|PubMed:17377532	278..336		13/87 (15%)
		FH_FOXP3	337..417	CDD:410840	52/79 (66%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22678915	414..417		1/2 (50%)