Protein Alignment FoxP and FOXP4

DIOPT Version :10

• Sequence 1: NP_001247011.1
• Gene: FoxP / 41182
• FlyBaseID: FBgn0262477
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_011512591.1
• Gene: FOXP4 / 116113
• HGNCID: 20842
• Length: 687
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 158/387 - (40%)
• Similarity: 193/387 - (49%)
• Gaps: 96/387 - (24%)

  Fly   155 HPLFAHGICRWPGCEMDLEDITSFVKHLNTEHGLDDRSTAQARVQMQVVSQLESHLQKERDRLQA 219
            |||:.||.|:|||||...||:..|:|||||||.||||||||.|||||||.|||..|.||.:||||
Human   308 HPLYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQA 372

  Fly   220 MMHHLYLSKQLLSPTKIDRKDVPGREGKFCRSPLTVNS-------IGRPIRQTNSP-SPLNLPMV 276
            ||.||::......|.......||| ...|  |.:||::       :..|.....:| :||..|.:
Human   373 MMAHLHMRPSEPKPFSQPLNPVPG-SSSF--SKVTVSAADSFPDGLVHPPTSAAAPVTPLRPPGL 434

  Fly   277 NSTNLCSIKKRNHDKNTFSINGGLPYMLERAGLD-----VQQEIHRNREFYKNADVRPPFTYASL 336
            .|.               |::||.|  ..|...|     :..|:.:|.|||||||||||||||||
Human   435 GSA---------------SLHGGGP--ARRRSSDKFCSPISSELAQNHEFYKNADVRPPFTYASL 482

  Fly   337 IRQAIIDSPDKQLTLNEIYNWFQNTFCYFRRNAATWKNAIRTNLSLHKCFVRYEDDFGSFWMVDD 401
            |||||:::||:|||||||||||...|.|||||.||||||:|.||||||||||.|:..|:.|.||:
Human   483 IRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDE 547

  Fly   402 NEFVKRR----------------HLSRGR-PRKYEPS---------SSPNSCQSGN--------- 431
            .|:.|||                .||.|. ...|:.:         :||.....|:
Human   548 REYQKRRPPKMTGSPTLVKNMISGLSYGALNASYQAALAESSFPLLNSPGMLNPGSASSLLPLSH 612

  Fly   432 ---GVPTDKNPCDNCTQHCTSLPP-------------------------GADNPLDSNNPND 465
               |.|.:..|.:..:......||                         ||.||..|..|.|
Human   613 DDVGAPVEPLPSNGSSSPPRLSPPQYSHQVQVKEEPAEAEEDRQPGPPLGAPNPSASGPPED 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:465036	46/66 (70%)
		FH_FOX	327..408	CDD:469596	58/80 (73%)
FOXP4	XP_011512591.1	FOXP-CC	310..377	CDD:465036	46/66 (70%)
		COG5025	<371..>567	CDD:227358	95/215 (44%)
		FH_FOXP4	474..560	CDD:410841	59/85 (69%)