Protein Alignment FoxP and FOXP4

DIOPT Version :9

• Sequence 1: NP_001247011.1
• Gene: FoxP / 41182
• FlyBaseID: FBgn0262477
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_011512591.1
• Gene: FOXP4 / 116113
• HGNCID: 20842
• Length: 687
• Species: Homo sapiens
• Alignment Length: 387
• Identity: 158/387 - (40%)
• Similarity: 193/387 - (49%)
• Gaps: 96/387 - (24%)

  Fly   155 HPLFAHGICRWPGCEMDLEDITSFVKHLNTEHGLDDRSTAQARVQMQVVSQLESHLQKERDRLQA 219
            |||:.||.|:|||||...||:..|:|||||||.||||||||.|||||||.|||..|.||.:||||
Human   308 HPLYGHGECKWPGCETLCEDLGQFIKHLNTEHALDDRSTAQCRVQMQVVQQLEIQLAKESERLQA 372

  Fly   220 MMHHLYLSKQLLSPTKIDRKDVPGREGKFCRSPLTVNS-------IGRPIRQTNSP-SPLNLPMV 276
            ||.||::......|.......||| ...|  |.:||::       :..|.....:| :||..|.:
Human   373 MMAHLHMRPSEPKPFSQPLNPVPG-SSSF--SKVTVSAADSFPDGLVHPPTSAAAPVTPLRPPGL 434

  Fly   277 NSTNLCSIKKRNHDKNTFSINGGLPYMLERAGLD-----VQQEIHRNREFYKNADVRPPFTYASL 336
            .|.               |::||.|  ..|...|     :..|:.:|.|||||||||||||||||
Human   435 GSA---------------SLHGGGP--ARRRSSDKFCSPISSELAQNHEFYKNADVRPPFTYASL 482

  Fly   337 IRQAIIDSPDKQLTLNEIYNWFQNTFCYFRRNAATWKNAIRTNLSLHKCFVRYEDDFGSFWMVDD 401
            |||||:::||:|||||||||||...|.|||||.||||||:|.||||||||||.|:..|:.|.||:
Human   483 IRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTATWKNAVRHNLSLHKCFVRVENVKGAVWTVDE 547

  Fly   402 NEFVKRR----------------HLSRGR-PRKYEPS---------SSPNSCQSGN--------- 431
            .|:.|||                .||.|. ...|:.:         :||.....|:
Human   548 REYQKRRPPKMTGSPTLVKNMISGLSYGALNASYQAALAESSFPLLNSPGMLNPGSASSLLPLSH 612

  Fly   432 ---GVPTDKNPCDNCTQHCTSLPP-------------------------GADNPLDSNNPND 465
               |.|.:..|.:..:......||                         ||.||..|..|.|
Human   613 DDVGAPVEPLPSNGSSSPPRLSPPQYSHQVQVKEEPAEAEEDRQPGPPLGAPNPSASGPPED 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:292777	46/66 (70%)
		FH	328..400	CDD:238016	53/71 (75%)
FOXP4	XP_011512591.1	FOXP-CC	310..377	CDD:292777	46/66 (70%)
		Forkhead	474..553	CDD:278670	56/78 (72%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5407
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001519
OrthoInspector	1	1.000	-	-		otm41385
orthoMCL	1	0.900	-	-		OOG6_103982
Panther	1	1.100	-	-	O	PTHR45796
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4064
SonicParanoid	1	1.000	-	-		X957
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.940