DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxP and Foxp2

DIOPT Version :9

Sequence 1:	NP_001247011.1	Gene:	FoxP / 41182	FlyBaseID:	FBgn0262477	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_036021645.1	Gene:	Foxp2 / 114142	MGIID:	2148705	Length:	740	Species:	Mus musculus

Alignment Length:	371	Identity:	159/371 - (42%)
Similarity:	202/371 - (54%)	Gaps:	75/371 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 SYMHDEFAMRKYYHPLFAHGICRWPGCEMDLEDITSFVKHLNTEHGLDDRSTAQARVQMQVVSQL 206
            |..|:|....   |.|:.||:|:|||||...||...|:||||.||.||||||||.|||||||.||
Mouse   355 SSSHEETGAS---HTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQL 416

  Fly   207 ESHLQKERDRLQAMMHHLYLSK----------QLLSPTKIDRKDVPGREGKFCRSPLTVNSIGRP 261
            |..|.|||:||||||.||::..          .|:|...:.:..:........::|.|..:...|
Mouse   417 EIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTP 481

  Fly   262 IRQTNSPS---PLNLPMVNSTNLCSIKKRNHDKNTFSINGGLPYMLERAGLDVQQEIHRNREFYK 323
            |  |..||   |.::|     |:.:|::|:.||               ..:.:..||..|.||||
Mouse   482 I--TQGPSVITPASVP-----NVGAIRRRHSDK---------------YNIPMSSEIAPNYEFYK 524

  Fly   324 NADVRPPFTYASLIRQAIIDSPDKQLTLNEIYNWFQNTFCYFRRNAATWKNAIRTNLSLHKCFVR 388
            |||||||||||:||||||::|.|:||||||||:||..||.||||||||||||:|.||||||||||
Mouse   525 NADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVR 589

  Fly   389 YEDDFGSFWMVDDNEFVKRRHLSRGRPRKYEPSSSPNSCQSGNGVPT-DKN-PCDNCTQHCTSLP 451
            .|:..|:.|.||:.|:.|||                  .|...|.|| .|| |        |||.
Mouse   590 VENVKGAVWTVDEVEYQKRR------------------SQKITGSPTLVKNIP--------TSLG 628

  Fly   452 PGADNPLDSNNPNDLGRIGCLPYCGSDGLSKASKDYSNMDSGMIES 497
            .||  .|:::....|.. ..||...:.||      .:|..||::::
Mouse   629 YGA--ALNASLQAALAE-SSLPLLSNPGL------INNASSGLLQA 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxP	NP_001247011.1	FOXP-CC	157..224	CDD:292777	46/66 (70%)
FoxP	NP_001247011.1	FH	328..400	CDD:238016	53/71 (75%)
Foxp2	XP_036021645.1	FOXP-CC	367..434	CDD:406546	46/66 (70%)
		COG5025	502..>733	CDD:227358	94/214 (44%)
		FH_FOXP2	528..609	CDD:410839	58/80 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5382
eggNOG	1	0.900	-	-		E2759_KOG4385
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4184
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001519
OrthoInspector	1	1.000	-	-		otm43440
orthoMCL	1	0.900	-	-		OOG6_103982
Panther	1	1.100	-	-	O	PTHR45796
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X957
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.720