DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8319 and ZSCAN32

DIOPT Version :9

Sequence 1:	NP_649920.2	Gene:	CG8319 / 41165	FlyBaseID:	FBgn0037722	Length:	383	Species:	Drosophila melanogaster
Sequence 2:	NP_001271456.1	Gene:	ZSCAN32 / 54925	HGNCID:	20812	Length:	697	Species:	Homo sapiens

Alignment Length:	294	Identity:	90/294 - (30%)
Similarity:	127/294 - (43%)	Gaps:	40/294 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 PNEEDFLFIENPDKGNLEAKKKLNKEIKKTHQTASRTT---------KSSITTSRAGRQLRSIKN 148
            ||...|.|.....|.||:.......||.|..|..||..         ..|..|||  ||.|:...
Human   408 PNRLGFEFKNEIKKENLKWDDSEEVEINKALQRKSRGVYWHSELQKGLESEPTSR--RQCRNSPG 470

  Fly   149 QTFKCELCIKQFKRQINLLDHMKVHSNSHVC------QNCEERFLFKADLDNHQCYRNS---NST 204
            ::.  |....|.|     :.|....:....|      :||.:..        |..::.:   ...
Human   471 ESE--EKTPSQEK-----MSHQSFCARDKACTHILCGKNCSQSV--------HSPHKPALKLEKV 520

  Fly   205 VECPECLKVFSSTQSLDSHKCKDMQERSPFQCPHCQQAFTREQNLKAHLLIHAESKQGNGPHKCS 269
            .:||||.|.||.:..|..|:.....|: |.:|..|.:.|:...||.|||..|.    |..|::|.
Human   521 SQCPECGKTFSRSSYLVRHQRIHTGEK-PHKCSECGKGFSERSNLTAHLRTHT----GERPYQCG 580

  Fly   270 YCQTGFFNKSALKVHIHAHMGERPHACPFCVSNFRSKQALKVHIRIHTGEKPYQCPHCPKTFSDN 334
            .|...|...|:|.||...|.||:|:.|..|...|.:......|.||||||.||:|..|.|.|:::
Human   581 QCGKSFNQSSSLIVHQRTHTGEKPYQCIVCGKRFNNSSQFSAHRRIHTGESPYKCAVCGKIFNNS 645

  Fly   335 NNLAKHRRRHSDERPYKCSICLQDFREKHHLKRH 368
            ::.:.||:.|:.|:||:||.|.:.|.:...|.||
Human   646 SHFSAHRKTHTGEKPYRCSHCERGFTKNSALTRH 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8319	NP_649920.2	zf-AD	4..79	CDD:285071
		COG5048	<153..368	CDD:227381	68/223 (30%)
		C2H2 Zn finger	153..173	CDD:275368	4/19 (21%)
		C2H2 Zn finger	179..196	CDD:275368	3/22 (14%)
		C2H2 Zn finger	207..227	CDD:275370	9/19 (47%)
		C2H2 Zn finger	236..256	CDD:275368	8/19 (42%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		zf-H2C2_2	308..332	CDD:290200	12/23 (52%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..368	CDD:275368	5/15 (33%)
ZSCAN32	NP_001271456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		SCAN	33..142	CDD:128708
		SCAN	33..121	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..177
		KRAB_A-box	218..250	CDD:295379
		Myb_DNA-bind_4	253..334	CDD:290549
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..482		10/39 (26%)
		COG5048	<455..668	CDD:227381	73/234 (31%)
		zf-C2H2	522..543	CDD:278523	9/20 (45%)
		C2H2 Zn finger	523..543	CDD:275368	9/19 (47%)
		zf-H2C2_2	535..559	CDD:290200	6/24 (25%)
		C2H2 Zn finger	551..571	CDD:275368	8/19 (42%)
		zf-H2C2_2	563..588	CDD:290200	11/28 (39%)
		C2H2 Zn finger	579..599	CDD:275368	7/19 (37%)
		zf-H2C2_2	591..616	CDD:290200	10/24 (42%)
		C2H2 Zn finger	607..627	CDD:275368	5/19 (26%)
		zf-H2C2_2	623..644	CDD:290200	13/20 (65%)
		C2H2 Zn finger	635..655	CDD:275368	6/19 (32%)
		zf-H2C2_2	647..671	CDD:290200	9/23 (39%)
		zf-C2H2	661..683	CDD:278523	8/19 (42%)
		C2H2 Zn finger	663..683	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000