DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment phu and Alppl2

DIOPT Version :10

Sequence 1:NP_649897.4 Gene:phu / 41135 FlyBaseID:FBgn0043791 Length:546 Species:Drosophila melanogaster
Sequence 2:NP_031459.3 Gene:Alppl2 / 11650 MGIID:108009 Length:529 Species:Mus musculus


Alignment Length:498 Identity:209/498 - (41%)
Similarity:290/498 - (58%) Gaps:33/498 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 QIVFDAVRSEERYAEYWQGLAAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLG- 116
            |:....:..||....:|...||:.||  ...||:.....|:|:::.:||||.:.|:||.|:..| 
Mouse    14 QVCPSVIPVEEENPAFWNRKAAEALD--AAKKLKPIQTSAKNLVILMGDGMGVSTVTATRILKGQ 76

  Fly   117 -----GEEKQFAFEQFPYVGLSKTYCANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQA 176
                 |.|.|.|.::||::.|||||..:.|:.|||.|.||:|.|||.|...||:|||.:|..|  
Mouse    77 QQGHLGPETQLAMDRFPHMALSKTYNTDKQIPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQC-- 139

  Fly   177 QAQAAHHVSSIAAWAQKQGMATGLVTTTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPD 241
            .....:.|.|:...|:|.|.:.|:||||||.||||||.|||..||.|.:||::.. :...|.|.|
Mouse   140 NTTWGNEVVSVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRGWYSDAQMPA-SALQDGCKD 203

  Fly   242 AAAQLINSPVGQKLNVIMGGGRENFLPKGV------TDSSGAPGRRLDGRNLIDEWKNQHTNSAQ 300
            .:.|||::   ..::||:||||:...|||.      ||:..| |.|||||||:.||..:| ..|:
Mouse   204 ISTQLISN---MDIDVILGGGRKFMFPKGTPDQEYPTDTKQA-GTRLDGRNLVQEWLAKH-QGAR 263

  Fly   301 YVENRRELL--NLSNHTSRVLGLFAPYHMAYHLDASPAEQPTLEEMVQSAMEILERQSAGRGYFL 363
            ||.||.||:  :|:...:.::|||.|..|.|.:...||:.|:|.||.:.|:.:|.|..  :|::|
Mouse   264 YVWNRSELIQASLNRSVTHLMGLFEPNDMKYEIHRDPAQDPSLAEMTEVAVRMLSRNP--KGFYL 326

  Fly   364 FVEGGRIDHGHHDTLALRAIDETAEFDKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKND 428
            ||||||||||||:|:|.||:.|...||.||..|...||..||:|:|::||||..|..||:.|...
Mouse   327 FVEGGRIDHGHHETVAYRALTEAVMFDSAVDKADKLTSEQDTMILVTADHSHVFSFGGYTQRGAS 391

  Fly   429 IFGINDGQLAADDLPYATLSYANGPGYDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESET 493
            |||:...: |.|...:.::.|.|||||.   |..|.   |.::......|..:...:.|||.|||
Mouse   392 IFGLAPFK-AEDGKSFTSILYGNGPGYK---LHNGA---RADVTEEESSNPTYQQQAAVPLSSET 449

  Fly   494 HGGDDVAVFASGPYAQLFTGVFEQHFIPHALGYASCLSDRNMC 536
            |.|:|||:||.||.|.|..||.||::|.|.:.:|:||.....|
Mouse   450 HSGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAACLEPYTDC 492

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
phuNP_649897.4 alkPPc 93..530 CDD:214515 195/450 (43%)
Alppl2NP_031459.3 Alk_phosphatase 51..486 CDD:395188 196/451 (43%)

Return to query results.
Submit another query.