Protein Alignment alpha-Man-IIa and MAN2C1

DIOPT Version :10

• Sequence 1: NP_001262413.1
• Gene: alpha-Man-IIa / 41126
• FlyBaseID: FBgn0011740
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: NP_001243423.1
• Gene: MAN2C1 / 4123
• HGNCID: 6827
• Length: 1057
• Species: Homo sapiens
• Alignment Length: 946
• Identity: 173/946 - (18%)
• Similarity: 293/946 - (30%)
• Gaps: 331/946 - (34%)

  Fly   152 HSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWA-----EISYFARFYHDLGENKKL 211
            |.|.|..|:..|:|..:...:..:: ||:.:..|||  ||:|     ::.:....|..|..
Human   258 HCHIDTAWLWPFKETVRKCARSWVT-ALQLMERNPE--FIFACSQAQQLEWVKSRYPGLYS---- 315

  Fly   212 QMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTM 276
            :::.....||...|.|.||..|........::.|..:||.:..|......:..|..|.||:|..:
Human   316 RIQEFACRGQFVPVGGTWVEMDGNLPSGEAMVRQFLQGQNFFLQEFGKMCSEFWLPDTFGYSAQL 380

  Fly   277 PYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGP 341
            |.|:...|.:..|.|:..:::.......       ...|:....:.:..|..|..||
Human   381 PQIMHGCGIRRFLTQKLSWNLVNSFPHH-------TFFWEGLDGSRVLVHFPPGDSY-------- 430

  Fly   342 DPKVCCQFDFKRMGSFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDF 406
                            |:....:...:|:::.....|::              .:..|...||..
Human   431 ----------------GMQGSVEEVLKTVANNRDKGRAN--------------HSAFLFGFGDGG 465

  Fly   407 RFKQNTEWDVQRVNYERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLSGDFFTY 471
            .....|..|    ..:||     |......:.|..:.::.|.|:    .:...:..|..|:.|.
Human   466 GGPTQTMLD----RLKRL-----SNTDGLPRVQLSSPRQLFSAL----ESDSEQLCTWVGELFL- 516

  Fly   472 ADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEMLSAWHSWDGMARIEE------RLEQARRELS 530
                 ...:|.||:....|:.:|.....:...|:||:.    .:||..:      :|:...|.|.
Human   517 -----ELHNGTYTTHAQIKKGNRECERILHDVELLSSL----ALARSAQFLYPAAQLQHLWRLLL 572

  Fly   531 LFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRW 595
            |.|.||.:||:                  ..|||.::::..                  .:|.|.
Human   573 LNQFHDVVTGS------------------CIQMVAEEAMCH------------------YEDIRS 601

  Fly   596 PGSGVEDSRTTIILGEDILPSKHVVMHNTLPHWREQLVDF------------------------Y 636
            .|:.:..:....:...:..|...::: ||||..|.:::..                        .
Human   602 HGNTLLSAAAAALCAGEPGPEGLLIV-NTLPWKRIEVMALPKPGGAHSLGLTPSPGDSAQHGLCS 665

  Fly   637 VSSPFVSVTDLANNP---VEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMG-LATYV 697
            .|||.::....|  |   |.:..:|..|......|||   .||.|....|.:.::.|.| |.:.|
Human   666 CSSPHLTAAPAA--PAACVRSARAPTDSASRPPPTKT---DGSVTLDNGIIRVKLDPTGRLTSLV 725

  Fly   698 LTISDSKPEHTSYASNLLLRKNPTSLPLGQYPEDVKFGDPREISLR---VGNGPTLAFSEQGLLK 759
            |..|..:........|..:..:  .:||.....||.   ...:..|   :|...|||...:|.|:
Human   726 LVASGREAIAEGAVGNQFVLFD--DVPLYWDAWDVM---DYHLETRKPVLGQAGTLAVGTEGGLR 785

  Fly   760 SIQ--LTQDSP-------------------HVPVHF----KFL---------------------- 777
            ...  |.|.||                   |..||:    |||
Human   786 GSAWFLLQISPNSRLSQEVVLDVGCPYVRFHTEVHWHEAHKFLKVEFPARVRSSQATYEIQFGHL 850

  Fly   778 --------------------------------------KYGVRSHGD-RSGAYLFLPNGPASPVE 803
                                                  |||....|. .|.:.|..|..|.:..:
Human   851 QRPTHYNTSWDWARFEVWAHRWMDLSEHGFGLALLNDCKYGASVRGSILSLSLLRAPKAPDATAD 915

  Fly   804 LGQP----VVLVTKGKLE-----------------------------SSVSVGLPSVVHQTIMRG 835
            .|:.    .::..||..:                             |:.||..|:||.:|:.:.
Human   916 TGRHEFTYALMPHKGSFQDAGVIQAAYSLNFPLLALPAPSPAPATSWSAFSVSSPAVVLETVKQA 980

  Fly   836 -GAPEIRNLVDIGSLDNTEIVMRL----ETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYY-- 893
             .:|:.|:|           |:||    .:|:|.    :..|:            ||:|....
Human   981 ESSPQRRSL-----------VLRLYEAHGSHVDC----WLHLS------------LPVQEAILCD 1018

  Fly   894 ----PIPSG-MFIEDANTRLT---------LLTGQP 915
                |.|:| :.:.|...:||         ||..||
Human  1019 LLERPDPAGHLTLRDNRLKLTFSPFQVLSLLLVLQP 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	PLN02701	105..990	CDD:178304	173/946 (18%)
		Glyc_hyd_38C_2	1020..1108	CDD:408054
MAN2C1	NP_001243423.1	MngB	247..1043	CDD:440152	169/933 (18%)