Protein Alignment alpha-Man-IIa and MAN2A2

DIOPT Version :10

• Sequence 1: NP_001262413.1
• Gene: alpha-Man-IIa / 41126
• FlyBaseID: FBgn0011740
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: NP_001307906.1
• Gene: MAN2A2 / 4122
• HGNCID: 6825
• Length: 1175
• Species: Homo sapiens
• Alignment Length: 1224
• Identity: 466/1224 - (38%)
• Similarity: 665/1224 - (54%)
• Gaps: 176/1224 - (14%)

  Fly     2 LRIRRRFALVICSG---CLLVFLSLYIILNFAAPAATQIKQPNYEN-----------IENKLHEL 52
            ::::::  :.:|..   |:.|| |||::|:     ..|.....::|           ::|::.:|
Human     1 MKLKKQ--VTVCGAAIFCVAVF-SLYLMLD-----RVQHDPTRHQNGGNFPRSQISVLQNRIEQL 57

  Fly    53 ENGLQEHGEEMRNLRARLAE-TSNRDDP-------------IRPPLKVARSPRPGQCQDVVQDV- 102
            |..|:|:.|.:.:::..:.| |:|.:.|             :.||     .|||.......||.
Human    58 EQLLEENHEIISHIKDSVLELTANAEGPPAMLPYYTVNGSWVVPP-----EPRPSFFSISPQDCQ 117

  Fly   103 -------PNVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWI 160
                   ...::|||.:.:.:.|.::|||||:||::|.|||..::| ..|:||||||||||||||
Human   118 FALGGRGQKPELQMLTVSEELPFDNVDGGVWRQGFDISYDPHDWDA-EDLQVFVVPHSHNDPGWI 181

  Fly   161 QTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFV 225
            :||::||...|:|||::.:..|.::|..:|:|||:|:||:::.::...|:..::.:|.|||||..
Human   182 KTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNINVQKRAAVRRLVGNGQLEIA 246

  Fly   226 TGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLI 290
            |||||||||||||:..::.||.||..||::.:..||.:.||:||||:|.||||:|:::...:|||
Human   247 TGGWVMPDEANSHYFALIDQLIEGHQWLERNLGATPRSGWAVDPFGYSSTMPYLLRRANLTSMLI 311

  Fly   291 QRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMG 355
            ||.||::||..|....|||:|||.||:...|.:|.|||||||||:|||||||||:||||||||:.
Human   312 QRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLP 376

  Fly   356 SFGLSCPWKVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVN 420
            ...::||||||||.|::.|||.|:.||:||::||::|:|:||||:|||||||:.:..|||.|..|
Human   377 GGRINCPWKVPPRAITEANVAERAALLLDQYRKKSQLFRSNVLLVPLGDDFRYDKPQEWDAQFFN 441

  Fly   421 YERLFEHINSQAHFNVQAQFGTLQEYFDAVHQAERAG------QAEFPTLSGDFFTYADRSDNYW 479
            |:|||:..||:.:.:||||||||.:||||::  :|.|      ...||.||||||:||||.|:||
Human   442 YQRLFDFFNSRPNLHVQAQFGTLSDYFDALY--KRTGVEPGARPPGFPVLSGDFFSYADREDHYW 504

  Fly   480 SGYYTSRPYHKRMDRVLMHYVRAAEM---LSAWHS-WDGMA-RIE----ERLEQARRELSLFQHH 535
            :|||||||::|.:||||..::|.||:   |:|.|: ..|:| |..    ..|.:|||.|.|||||
Human   505 TGYYTSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDFTLLTEARRTLGLFQHH 569

  Fly   536 DGITGTAKTHVVVDYEQRMQEAL-KACQMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSG 599
            |.||||||..|||||..|:..:| ...|:::..:.|.:|.....|..|....:..:||:|.....
Human   570 DAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQVDDTRLSHDA 634

  Fly   600 VEDSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHH 664
            :.: ||.|.|  |..| :.||:.|.|...|..:|...|:||.|.|......|:..|:|..||
Human   635 LPE-RTVIQL--DSSP-RFVVLFNPLEQERFSMVSLLVNSPRVRVLSEEGQPLAVQISAHWS--- 692

  Fly   665 DTLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYP 729
             :.|:.:     ...|::....|:|.:||.  ||.:......|         |..|:|:.:..:.
Human   693 -SATEAV-----PDVYQVSVPVRLPALGLG--VLQLQLGLDGH---------RTLPSSVRIYLHG 740

  Fly   730 EDVKFGDPREISLRVGNGPTLAFSEQ------------GLLKSIQLTQDSPHVPVHFKFLKYGVR 782
            ..:.........|||.:..|..|:..            ||||||:...:.....|..:.|.||.|
Human   741 RQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGLLKSIRRVDEEHEQQVDMQVLVYGTR 805

  Fly   783 SHGDRSGAYLFLPNGPASP-VELGQPVVLVTKGKLESSVSVGLPSVVHQTI-------MRGGAPE 839
            :..|:||||||||:|.|.| |....||:.||:|...|.| |.....:||.:       :.|.:.:
Human   806 TSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPFFSEV-VAYYEHIHQAVRLYNLPGVEGLSLD 869

  Fly   840 IRNLVDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDA 904
            |.:||||....|.|:.:.:.|.|||..||:|||||.|...||.|.|||||||:||:|...:|:||
Human   870 ISSLVDIRDYVNKELALHIHTDIDSQGIFFTDLNGFQVQPRRYLKKLPLQANFYPMPVMAYIQDA 934

  Fly   905 NTRLTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRP 969
            ..||||.|.|.||.|||..|:||::.||||..||.||||||:.|||...:.:||:||:......|
Human   935 QKRLTLHTAQALGVSSLKDGQLEVILDRRLMQDDNRGLGQGLKDNKRTCNRFRLLLERRTVGSEP 999

  Fly   970 -------------------------SELHPAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQ 1009
                                     .:.|...|.:..:|..|..|..|......|..:..|.  .
Human  1000 DFFSKLAAMFRGLIFHSSRSGNREVQDSHSTSYPSLLSHLTSMYLNAPALALPVARMQLPGP--G 1062

  Fly  1010 FGGDHPSARE---DLDVSVMRRL-----TKSSAKTQRVGYVLHRTNLMQCGTPEEHT-------- 1058
            ....||.|..   |..:..:|.|     |..||:|   ..:|||.. ..||...::.
Human  1063 LRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAET---ALILHRKG-FDCGLEAKNLGFNCTTSQ 1123

  Fly  1059 ---------QKLDVCHLLPNVARCERTTLTFLQNLEHLDGMVAPEVCPMETAAY 1103
                     ..|||..|.|       |:||.|..|..........:.|||.|.:
Human  1124 GKVALGSLFHGLDVVFLQP-------TSLTLLYPLASPSNSTDVYLEPMEIATF 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	PLN02701	105..990	CDD:178304	406/945 (43%)
		Glyc_hyd_38C_2	1020..1108	CDD:408054	26/106 (25%)
MAN2A2	NP_001307906.1	PLN02701	136..1174	CDD:178304	436/1076 (41%)