DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and aman-1

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_508811.1	Gene:	aman-1 / 180749	WormBaseID:	WBGene00018877	Length:	955	Species:	Caenorhabditis elegans

Alignment Length:	955	Identity:	262/955 - (27%)
Similarity:	396/955 - (41%)	Gaps:	232/955 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 WN----IKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYY--------QHDTKHILSNALRHL 182
            ||    :..||....||      ::||:|:|.|||:|.::|:        ....::|.:..:..|
Worm    23 WNTCHKVDQDPNVITAH------LIPHTHDDLGWIKTVDQYFWGAKPELVPVGVQYIYNTVIDEL 81

  Fly   183 HDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLT 247
            ..||:.:|.:||..:..|:|....:..:.|::.:|||||:|.:.||||..|||.||:.:::.|:|
Worm    82 LKNPDRRFSFAETGFLWRWYTSNSDFDRHQLQKLVKNGQIEIIGGGWVQNDEATSHYVDIIDQMT 146

  Fly   248 EGQTWLKQFMNV--TPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFL 310
            .|...|:|....  .|...|.|||||||..|..|.::.|:.::...|.||..|:...:.:.|||:
Worm   147 LGLQRLEQIFGECGKPVTGWQIDPFGHSREMANIYREMGYSSVYFARIHYLEKQIRLKNKTLEFM 211

  Fly   311 WR---QIWDNKGDTALFTHMMPFYSYDIPH------TCGPDPKVCCQFDFKRMGSFGLSCPWKVP 366
            |.   .|.|||    |||......:|..|.      .||.||                    .:.
Worm   212 WNTSDDITDNK----LFTGAFFNDNYGPPEGFCWDSLCGDDP--------------------IMD 252

  Fly   367 PRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQ 431
            ...|...||..:.|..||..|.:|....||.:::.:|.||::.....|   .||.::|.:::|:.
Worm   253 NLNIEGYNVKEKVDAFVDHVKNQAAHQSTNQVMLLMGSDFQYTNANSW---YVNLDKLIKYVNAD 314

  Fly   432 AHFNVQAQFGTLQEYFDAVHQAERAGQAEFPTLS---GDFFTYADRSDNYWSGYYTSRPYHKRMD 493
            ....|:..:.|...|..||       ||:.||||   .|||.||....:||:||:||||..|.|.
Worm   315 TSKKVRVIYSTPACYTKAV-------QAKTPTLSVKHDDFFPYASGRHSYWTGYFTSRPAFKGMI 372

  Fly   494 RVLMHYVRAAEMLSAWHSWDGMARI----EERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRM 554
            |      :|:.||......|.:|.:    :..:|..|...:|.||||.:|||||.:|..|||:::
Worm   373 R------QASCMLQLAKQLDVIANLGPEDDSDIEILREASALVQHHDAVTGTAKENVTRDYEKQL 431

  Fly   555 QEALKACQMVMQQSVYRL------------------LTKPSIYSPDFSFSYFTLDDSRWPGS-GV 600
            .:.:...::|:...:.::                  :.||...|.:||...|..:...:.|: .:
Worm   432 AKGVSEVEVVINDFMKKMNPDGLDPKLVLCPLINETICKPINGSSEFSVVIFNSNGRYFNGTIRI 496

  Fly   601 EDSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHD 665
            ..|:.|.:|                                   .|...|.:|:|:  |.::..|
Worm   497 PYSQKTAVL-----------------------------------RDAHKNVLESQI--VETFQID 524

  Fly   666 TLTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQYPE 730
            .|..|     ....|.|....||||:|..| |.....||||...:.:    ||
Worm   525 QLKDT-----DRLPYEIHVFVRVPPLGYTT-VFVEKGSKPERVHFNN----RK------------ 567

  Fly   731 DVKFGDPREISLRVGNGPTLA-FSEQGLLKSIQLTQDSPHVPVHFKFLKY-GVRSHGDR-SGAYL 792
              ||....||.    |...:| |..||.|..|..........:..:|..| |:.|..|: ||||:
Worm   568 --KFNTNVEIQ----NEYLIAGFDSQGYLSYITEKATKKKRSIRQEFFYYEGIDSKDDQPSGAYI 626

  Fly   793 FLPNGPASPVELGQPVVLVTK-------GKLESSVSVGLPSVVHQTIMRGGAPEIRNLVD----I 846
            |.|       :..||:.|.:|       |.:.:.|...:...|.|.|.   .|..:|.::    :
Worm   627 FRP-------KTQQPIALTSKLALEVVPGAIINEVRQKVSPFVSQQIR---LPRGKNYIEFEWIV 681

  Fly   847 GSLD-------NTEIVMRLETHIDSGDIFYTDLNGLQFIKR--------RRLDKLPLQANYYPIP 896
            |.:.       ..|.|.|..|.:.|.:..:||.||.|.::|        ...|..|:..|||||.
Worm   682 GPIPKETKNPITKEFVTRYTTEVHSKNQSFTDSNGRQAMERFFDGATSFEYSDTEPIAGNYYPIT 746

  Fly   897 SGMFIEDANTRLTLLTGQPLGGSSLAS-GELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVL 960
            |..:|:|.|.:.:::|.:..|  .:|| |.:|||..||...||..|: :..||
Worm   747 SFGYIKDENAQFSVITDRAQG--MVASDGVVEIMLHRRCFYDDHFGV-EEALD------------ 796

  Fly   961 EKVNNCVRPSELHPAGYLTSAAH-------KASQSLLDPL--DKF 996
                   .|.: ..||.:....|       |||.|.|.||  |.|
Worm   797 -------EPGK-DGAGLVAMGKHIVLFTDVKASTSQLRPLAIDNF 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	109/360 (30%)
		Alpha-mann_mid	478..554	CDD:214875	32/79 (41%)
		Glyco_hydro_38C	744..1103	CDD:285047	80/292 (27%)
aman-1	NP_508811.1	GH38N_AMII_LAM_like	36..313	CDD:212121	91/309 (29%)
		Alpha-mann_mid	357..431	CDD:286360	32/79 (41%)
		Glyco_hydro_38C	537..944	CDD:285047	97/353 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840