Protein Alignment: alpha-Man-IIa and Man2a2

• Sequence 1: NP_001262413.1
• Gene: alpha-Man-IIa
• FlyBaseID: FBgn0011740
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: NP_766491.2
• Gene: Man2a2
• MGIID: 2150656
• Length: 1152
• Species: Mus musculus
• Alignment Length: 1197
• Identity: 459/1198 (38%)
• Similarity: 658/1198 (55%)
• Gaps: 145/1198 (12%)

  Fly     2 LRIRRRFALVICSG---CLLVFLSLYIILNFAA--PAATQ----IKQPNYENIENKLHELENGLQ 57
            ::::::  :.:|..   |:.|| |||::|:...  ||..|    ..:.....::|::.:||..|:
Mouse     1 MKLKKQ--VTVCGAAIFCVAVF-SLYLMLDRVQHDPARHQNGGNFPRSQISVLQNRIEQLEQLLE 62

  Fly    58 EHGEEMRNLRARLAE-TSNRDDPIRPPL----------KVARSPRPGQCQDVVQDV--------P 103
            |:.:.:..::..:.| |:|.:.|  |.|          .|...|||.......||.        .
Mouse    63 ENHDIISRIKDSVLELTANAEGP--PALLPYHTANGSWAVLPEPRPSFFSVSPQDCQFALGGRGQ 125

  Fly   104 NVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQ 168
            ..::|||.:.:.:.|.:::||||:||::|.|.|..::. ..|:||||||||||||||:||::||.
Mouse   126 KPELQMLTVSEDLPFDNVEGGVWRQGFDISYSPNDWDT-EDLQVFVVPHSHNDPGWIKTFDKYYT 189

  Fly   169 HDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPD 233
            ..|:|||::.:..|.::|..:|:|||:|:||:::.::...|:..::.:|.|||||..||||||||
Mouse   190 EQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPD 254

  Fly   234 EANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVK 298
            |||||:..::.||.||..||::.:..||.:.||:||||||.||||:|:::...:|||||.||::|
Mouse   255 EANSHYFALVDQLIEGHQWLERNLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIK 319

  Fly   299 KELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPW 363
            |..|....|||:|||:||:...|.:|.|||||||||:|||||||||:||||||||:....::|||
Mouse   320 KHFAATHSLEFMWRQMWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPW 384

  Fly   364 KVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHI 428
            |||||.|::.|||.|:.||:||::||:.|:|:||||:|||||||:.:..|||.|..||:|||:.:
Mouse   385 KVPPRAITEANVADRAALLLDQYRKKSRLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFL 449

  Fly   429 NSQAHFNVQAQFGTLQEYFDAVHQAERAG------QAEFPTLSGDFFTYADRSDNYWSGYYTSRP 487
            ||:..|:||||||||.|||||::  :|.|      ...||.||||||:||||.|:||:|||||||
Mouse   450 NSKPEFHVQAQFGTLSEYFDALY--KRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRP 512

  Fly   488 YHKRMDRVLMHYVRAAEMLSAWHSWDGMARIEER---------------LEQARRELSLFQHHDG 537
            ::|.:||||..::|.||:|.:      :|....|               |.:|||.|.||||||.
Mouse   513 FYKSLDRVLEAHLRGAEILYS------LALAHARRSGLAGQYPLSDFALLTEARRTLGLFQHHDA 571

  Fly   538 ITGTAKTHVVVDYEQRMQEALKAC-QMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVE 601
            ||||||..|||||..|:..:|.:. |:::..:.|.:|.....||.|....:..:||||.....:.
Mouse   572 ITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDQETYSFDPGTPFLQMDDSRVSHDALP 636

  Fly   602 DSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDT 666
            : ||.|.|  |..| :.||:.|.|...|..:|...|:||.|.|......|:..|:|..||...|.
Mouse   637 E-RTVIRL--DSSP-RFVVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQPLSVQISVHWSSATDM 697

  Fly   667 LTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQ---Y 728
            :...         |::....|:|.:||.  ||.:........:..|::.:..|...|.:.:   :
Mouse   698 VPDV---------YQVSVPVRLPGLGLG--VLQLQPDLDGPYTLQSSVRVYLNGVKLSVSRQSAF 751

  Fly   729 PEDVKFGDPREISLRVGN--------GPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHG 785
            |  |:..|.......:.|        |.|      ||||||:...:.....:..:||.||.|:..
Mouse   752 P--VRVVDSGASDFAISNRYMQVWFSGLT------GLLKSIRRVDEEQEQQMELEFLVYGTRTSK 808

  Fly   786 DRSGAYLFLPNGPASP-VELGQPVVLVTKGKLESSVSVGLPSVVHQTIMRGGAPEIRNL------ 843
            |:||||||||:..|.| |....||:.||:|...|.|:|.... .||.|.....|.:..|
Mouse   809 DKSGAYLFLPDSEAKPYVPKKPPVLRVTEGPFFSEVAVYYEH-FHQVIRLYNLPGVEGLSLDMSF 872

  Fly   844 -VDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTR 907
             |||....|.|:.:|:.|.|||...|:|||||.|...|:.|.|||||||:||:|...:|:|:..|
Mouse   873 QVDIRDYVNKELALRIHTDIDSQGTFFTDLNGFQIQPRQYLKKLPLQANFYPMPVMAYIQDSQRR 937

  Fly   908 LTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSEL 972
            |||.|.|.||.|||.:|:||::.||||..||.||||||:.|||...:.:||:||: ...:.| |:
Mouse   938 LTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGLGQGLKDNKITCNRFRLLLER-RTTMSP-EV 1000

  Fly   973 H-----PAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSARE---DLDVSVMRRL 1029
            |     ...|.:..:|..|..|..|......|:.:  |........||.|..   |..:..:|.|
Mouse  1001 HQEQERSTSYPSLLSHLTSMYLSTPPLVLPVAKRQ--GTSPALRSFHPLASPLPCDFHLLNLRML 1063

  Fly  1030 -TKSSAKTQRVGYVLHRTNLMQCGTPEEHT-----------------QKLDVCHLLPNVARCERT 1076
             .:.:........:|||.. ..||...::.                 ..|||..|.|       |
Mouse  1064 PAEDTLPATDSALILHRKG-FDCGLEAKNLGFNCTTSQGKLALGSLFHGLDVTFLQP-------T 1120

  Fly  1077 TLTFLQNLEHLDGMVAPEVCPMETAAY 1103
            :||.|..|..........:.|||.:.:
Mouse  1121 SLTLLYPLASPSNSTDISLEPMEISTF 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	195/345 (57%)
		Alpha-mann_mid	478..554	CDD:214875	43/91 (47%)
		Glyco_hydro_38C	744..1103	CDD:285047	137/401 (34%)
Man2a2	NP_766491.2	PLN02701	140..1151	CDD:178304	428/1054 (41%)
		CE4_SF	165..508	CDD:301698	195/345 (57%)
		Alpha-mann_mid	503..588	CDD:214875	43/91 (47%)
		Glyco_hydro_38C	752..1147	CDD:285047	140/416 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C64041491
eggNOG	1	0.900				E1_KOG1959
Hieranoid	1	1.000
Homologene	1	1.000				H55954
Inparanoid	1	1.050	761	1.000	Inparanoid score	I538
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0002017
OrthoInspector	1	1.000				T615910
orthoMCL	1	0.900				OOG5_130088
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R3970
TreeFam	1	0.960
	11	10.780