Protein Alignment alpha-Man-IIa and Man2a2

DIOPT Version :10

• Sequence 1: NP_001262413.1
• Gene: alpha-Man-IIa / 41126
• FlyBaseID: FBgn0011740
• Length: 1109
• Species: Drosophila melanogaster
• Sequence 2: NP_766491.2
• Gene: Man2a2 / 140481
• MGIID: 2150656
• Length: 1152
• Species: Mus musculus
• Alignment Length: 1197
• Identity: 459/1197 - (38%)
• Similarity: 658/1197 - (54%)
• Gaps: 145/1197 - (12%)

  Fly     2 LRIRRRFALVICSG---CLLVFLSLYIILNFAA--PAATQ----IKQPNYENIENKLHELENGLQ 57
            ::::::  :.:|..   |:.|| |||::|:...  ||..|    ..:.....::|::.:||..|:
Mouse     1 MKLKKQ--VTVCGAAIFCVAVF-SLYLMLDRVQHDPARHQNGGNFPRSQISVLQNRIEQLEQLLE 62

  Fly    58 EHGEEMRNLRARLAE-TSNRDDPIRPPL----------KVARSPRPGQCQDVVQDV--------P 103
            |:.:.:..::..:.| |:|.:.|  |.|          .|...|||.......||.        .
Mouse    63 ENHDIISRIKDSVLELTANAEGP--PALLPYHTANGSWAVLPEPRPSFFSVSPQDCQFALGGRGQ 125

  Fly   104 NVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQ 168
            ..::|||.:.:.:.|.:::||||:||::|.|.|..::. ..|:||||||||||||||:||::||.
Mouse   126 KPELQMLTVSEDLPFDNVEGGVWRQGFDISYSPNDWDT-EDLQVFVVPHSHNDPGWIKTFDKYYT 189

  Fly   169 HDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPD 233
            ..|:|||::.:..|.::|..:|:|||:|:||:::.::...|:..::.:|.|||||..||||||||
Mouse   190 EQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPD 254

  Fly   234 EANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVK 298
            |||||:..::.||.||..||::.:..||.:.||:||||||.||||:|:::...:|||||.||::|
Mouse   255 EANSHYFALVDQLIEGHQWLERNLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIK 319

  Fly   299 KELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPW 363
            |..|....|||:|||:||:...|.:|.|||||||||:|||||||||:||||||||:....::|||
Mouse   320 KHFAATHSLEFMWRQMWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPW 384

  Fly   364 KVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHI 428
            |||||.|::.|||.|:.||:||::||:.|:|:||||:|||||||:.:..|||.|..||:|||:.:
Mouse   385 KVPPRAITEANVADRAALLLDQYRKKSRLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFL 449

  Fly   429 NSQAHFNVQAQFGTLQEYFDAVHQAERAG------QAEFPTLSGDFFTYADRSDNYWSGYYTSRP 487
            ||:..|:||||||||.|||||::  :|.|      ...||.||||||:||||.|:||:|||||||
Mouse   450 NSKPEFHVQAQFGTLSEYFDALY--KRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRP 512

  Fly   488 YHKRMDRVLMHYVRAAEMLSAWHSWDGMARIEER---------------LEQARRELSLFQHHDG 537
            ::|.:||||..::|.||:|.:      :|....|               |.:|||.|.||||||.
Mouse   513 FYKSLDRVLEAHLRGAEILYS------LALAHARRSGLAGQYPLSDFALLTEARRTLGLFQHHDA 571

  Fly   538 ITGTAKTHVVVDYEQRMQEALKAC-QMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVE 601
            ||||||..|||||..|:..:|.:. |:::..:.|.:|.....||.|....:..:||||.....:.
Mouse   572 ITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDQETYSFDPGTPFLQMDDSRVSHDALP 636

  Fly   602 DSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDT 666
            : ||.|.|  |..| :.||:.|.|...|..:|...|:||.|.|......|:..|:|..||...|.
Mouse   637 E-RTVIRL--DSSP-RFVVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQPLSVQISVHWSSATDM 697

  Fly   667 LTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQ---Y 728
            :...         |::....|:|.:||.  ||.:........:..|::.:..|...|.:.:   :
Mouse   698 VPDV---------YQVSVPVRLPGLGLG--VLQLQPDLDGPYTLQSSVRVYLNGVKLSVSRQSAF 751

  Fly   729 PEDVKFGDPREISLRVGN--------GPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHG 785
            |  |:..|.......:.|        |.|      ||||||:...:.....:..:||.||.|:..
Mouse   752 P--VRVVDSGASDFAISNRYMQVWFSGLT------GLLKSIRRVDEEQEQQMELEFLVYGTRTSK 808

  Fly   786 DRSGAYLFLPNGPASP-VELGQPVVLVTKGKLESSVSVGLPSVVHQTIMRGGAPEIRNL------ 843
            |:||||||||:..|.| |....||:.||:|...|.|:|.... .||.|.....|.:..|
Mouse   809 DKSGAYLFLPDSEAKPYVPKKPPVLRVTEGPFFSEVAVYYEH-FHQVIRLYNLPGVEGLSLDMSF 872

  Fly   844 -VDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTR 907
             |||....|.|:.:|:.|.|||...|:|||||.|...|:.|.|||||||:||:|...:|:|:..|
Mouse   873 QVDIRDYVNKELALRIHTDIDSQGTFFTDLNGFQIQPRQYLKKLPLQANFYPMPVMAYIQDSQRR 937

  Fly   908 LTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSEL 972
            |||.|.|.||.|||.:|:||::.||||..||.||||||:.|||...:.:||:||: ...:.| |:
Mouse   938 LTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGLGQGLKDNKITCNRFRLLLER-RTTMSP-EV 1000

  Fly   973 H-----PAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSARE---DLDVSVMRRL 1029
            |     ...|.:..:|..|..|..|......|:.:  |........||.|..   |..:..:|.|
Mouse  1001 HQEQERSTSYPSLLSHLTSMYLSTPPLVLPVAKRQ--GTSPALRSFHPLASPLPCDFHLLNLRML 1063

  Fly  1030 -TKSSAKTQRVGYVLHRTNLMQCGTPEEHT-----------------QKLDVCHLLPNVARCERT 1076
             .:.:........:|||.. ..||...::.                 ..|||..|.|       |
Mouse  1064 PAEDTLPATDSALILHRKG-FDCGLEAKNLGFNCTTSQGKLALGSLFHGLDVTFLQP-------T 1120

  Fly  1077 TLTFLQNLEHLDGMVAPEVCPMETAAY 1103
            :||.|..|..........:.|||.:.:
Mouse  1121 SLTLLYPLASPSNSTDISLEPMEISTF 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	PLN02701	105..990	CDD:178304	403/930 (43%)
		Glyc_hyd_38C_2	1020..1108	CDD:408054	21/102 (21%)
Man2a2	NP_766491.2	PLN02701	140..1151	CDD:178304	428/1053 (41%)