DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and Man2a2

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	NP_766491.2	Gene:	Man2a2 / 140481	MGIID:	2150656	Length:	1152	Species:	Mus musculus

Alignment Length:	1197	Identity:	459/1197 - (38%)
Similarity:	658/1197 - (54%)	Gaps:	145/1197 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LRIRRRFALVICSG---CLLVFLSLYIILNFAA--PAATQ----IKQPNYENIENKLHELENGLQ 57
            ::::::  :.:|..   |:.|| |||::|:...  ||..|    ..:.....::|::.:||..|:
Mouse     1 MKLKKQ--VTVCGAAIFCVAVF-SLYLMLDRVQHDPARHQNGGNFPRSQISVLQNRIEQLEQLLE 62

  Fly    58 EHGEEMRNLRARLAE-TSNRDDPIRPPL----------KVARSPRPGQCQDVVQDV--------P 103
            |:.:.:..::..:.| |:|.:.|  |.|          .|...|||.......||.        .
Mouse    63 ENHDIISRIKDSVLELTANAEGP--PALLPYHTANGSWAVLPEPRPSFFSVSPQDCQFALGGRGQ 125

  Fly   104 NVDVQMLELYDRMSFKDIDGGVWKQGWNIKYDPLKYNAHHKLKVFVVPHSHNDPGWIQTFEEYYQ 168
            ..::|||.:.:.:.|.:::||||:||::|.|.|..::. ..|:||||||||||||||:||::||.
Mouse   126 KPELQMLTVSEDLPFDNVEGGVWRQGFDISYSPNDWDT-EDLQVFVVPHSHNDPGWIKTFDKYYT 189

  Fly   169 HDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHDLGENKKLQMKSIVKNGQLEFVTGGWVMPD 233
            ..|:|||::.:..|.::|..:|:|||:|:||:::.::...|:..::.:|.|||||..||||||||
Mouse   190 EQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKWWDNISAQKRAAVRRLVGNGQLEIATGGWVMPD 254

  Fly   234 EANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAIDPFGHSPTMPYILQKSGFKNMLIQRTHYSVK 298
            |||||:..::.||.||..||::.:..||.:.||:||||||.||||:|:::...:|||||.||::|
Mouse   255 EANSHYFALVDQLIEGHQWLERNLGATPRSGWAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIK 319

  Fly   299 KELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSYDIPHTCGPDPKVCCQFDFKRMGSFGLSCPW 363
            |..|....|||:|||:||:...|.:|.|||||||||:|||||||||:||||||||:....::|||
Mouse   320 KHFAATHSLEFMWRQMWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPW 384

  Fly   364 KVPPRTISDQNVAARSDLLVDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHI 428
            |||||.|::.|||.|:.||:||::||:.|:|:||||:|||||||:.:..|||.|..||:|||:.:
Mouse   385 KVPPRAITEANVADRAALLLDQYRKKSRLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFL 449

  Fly   429 NSQAHFNVQAQFGTLQEYFDAVHQAERAG------QAEFPTLSGDFFTYADRSDNYWSGYYTSRP 487
            ||:..|:||||||||.|||||::  :|.|      ...||.||||||:||||.|:||:|||||||
Mouse   450 NSKPEFHVQAQFGTLSEYFDALY--KRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRP 512

  Fly   488 YHKRMDRVLMHYVRAAEMLSAWHSWDGMARIEER---------------LEQARRELSLFQHHDG 537
            ::|.:||||..::|.||:|.:      :|....|               |.:|||.|.||||||.
Mouse   513 FYKSLDRVLEAHLRGAEILYS------LALAHARRSGLAGQYPLSDFALLTEARRTLGLFQHHDA 571

  Fly   538 ITGTAKTHVVVDYEQRMQEALKAC-QMVMQQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVE 601
            ||||||..|||||..|:..:|.:. |:::..:.|.:|.....||.|....:..:||||.....:.
Mouse   572 ITGTAKEAVVVDYGVRLLRSLVSLKQVIINAAHYLVLGDQETYSFDPGTPFLQMDDSRVSHDALP 636

  Fly   602 DSRTTIILGEDILPSKHVVMHNTLPHWREQLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDT 666
            : ||.|.|  |..| :.||:.|.|...|..:|...|:||.|.|......|:..|:|..||...|.
Mouse   637 E-RTVIRL--DSSP-RFVVVFNPLEQERLSVVSLLVNSPRVRVLSEEGQPLSVQISVHWSSATDM 697

  Fly   667 LTKTIHPQGSTTKYRIIFKARVPPMGLATYVLTISDSKPEHTSYASNLLLRKNPTSLPLGQ---Y 728
            :...         |::....|:|.:||.  ||.:........:..|::.:..|...|.:.:   :
Mouse   698 VPDV---------YQVSVPVRLPGLGLG--VLQLQPDLDGPYTLQSSVRVYLNGVKLSVSRQSAF 751

  Fly   729 PEDVKFGDPREISLRVGN--------GPTLAFSEQGLLKSIQLTQDSPHVPVHFKFLKYGVRSHG 785
            |  |:..|.......:.|        |.|      ||||||:...:.....:..:||.||.|:..
Mouse   752 P--VRVVDSGASDFAISNRYMQVWFSGLT------GLLKSIRRVDEEQEQQMELEFLVYGTRTSK 808

  Fly   786 DRSGAYLFLPNGPASP-VELGQPVVLVTKGKLESSVSVGLPSVVHQTIMRGGAPEIRNL------ 843
            |:||||||||:..|.| |....||:.||:|...|.|:|.... .||.|.....|.:..|
Mouse   809 DKSGAYLFLPDSEAKPYVPKKPPVLRVTEGPFFSEVAVYYEH-FHQVIRLYNLPGVEGLSLDMSF 872

  Fly   844 -VDIGSLDNTEIVMRLETHIDSGDIFYTDLNGLQFIKRRRLDKLPLQANYYPIPSGMFIEDANTR 907
             |||....|.|:.:|:.|.|||...|:|||||.|...|:.|.|||||||:||:|...:|:|:..|
Mouse   873 QVDIRDYVNKELALRIHTDIDSQGTFFTDLNGFQIQPRQYLKKLPLQANFYPMPVMAYIQDSQRR 937

  Fly   908 LTLLTGQPLGGSSLASGELEIMQDRRLASDDERGLGQGVLDNKPVLHIYRLVLEKVNNCVRPSEL 972
            |||.|.|.||.|||.:|:||::.||||..||.||||||:.|||...:.:||:||: ...:.| |:
Mouse   938 LTLHTAQALGVSSLGNGQLEVILDRRLMQDDNRGLGQGLKDNKITCNRFRLLLER-RTTMSP-EV 1000

  Fly   973 H-----PAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHPSARE---DLDVSVMRRL 1029
            |     ...|.:..:|..|..|..|......|:.:  |........||.|..   |..:..:|.|
Mouse  1001 HQEQERSTSYPSLLSHLTSMYLSTPPLVLPVAKRQ--GTSPALRSFHPLASPLPCDFHLLNLRML 1063

  Fly  1030 -TKSSAKTQRVGYVLHRTNLMQCGTPEEHT-----------------QKLDVCHLLPNVARCERT 1076
             .:.:........:|||.. ..||...::.                 ..|||..|.|       |
Mouse  1064 PAEDTLPATDSALILHRKG-FDCGLEAKNLGFNCTTSQGKLALGSLFHGLDVTFLQP-------T 1120

  Fly  1077 TLTFLQNLEHLDGMVAPEVCPMETAAY 1103
            :||.|..|..........:.|||.:.:
Mouse  1121 SLTLLYPLASPSNSTDISLEPMEISTF 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	194/344 (56%)
		Alpha-mann_mid	478..554	CDD:214875	42/90 (47%)
		Glyco_hydro_38C	744..1103	CDD:285047	137/400 (34%)
Man2a2	NP_766491.2	PLN02701	140..1151	CDD:178304	428/1053 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838009
Domainoid	1	1.000	430	1.000	Domainoid score	I586
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55954
Inparanoid	1	1.050	761	1.000	Inparanoid score	I543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55783
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002281
OrthoInspector	1	1.000	-	-		otm44240
orthoMCL	1	0.900	-	-		OOG6_102728
Panther	1	1.100	-	-	O	PTHR11607
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3970
SonicParanoid	1	1.000	-	-		X2015
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790