DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Man-IIa and man2b2

DIOPT Version :9

Sequence 1:	NP_001262413.1	Gene:	alpha-Man-IIa / 41126	FlyBaseID:	FBgn0011740	Length:	1109	Species:	Drosophila melanogaster
Sequence 2:	XP_001337519.3	Gene:	man2b2 / 100003570	ZFINID:	ZDB-GENE-140106-166	Length:	1006	Species:	Danio rerio

Alignment Length:	1052	Identity:	263/1052 - (25%)
Similarity:	435/1052 - (41%)	Gaps:	209/1052 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 NAHHKLKVFVVPHSHNDPGWIQTFEEYYQHDTKHILSNALRHLHDNPEMKFIWAEISYFARFYHD 204
            :|..|::.||:||||.|.||:.|.:|.......::.|..:..|......|||..|..:|..::.:
Zfish    18 DAAEKIQAFVIPHSHMDVGWVYTVQESMHAYASNVYSTVVEELTRVKNRKFIAVEQEFFRLWWTN 82

  Fly   205 LGEN-KKLQMKSIVKNGQLEFVTGGWVMPDEANSHWRNVLLQLTEGQTWLKQFMNVTPTASWAID 268
            :..: .|.|::.::..|:|||:.||.||.|||.:...:.:||||||..:|.:...|.|..:|.:|
Zfish    83 VASDWHKKQVRQLLLEGRLEFIIGGQVMHDEAVTDVDDAILQLTEGHGFLYETFGVRPRFAWHVD 147

  Fly   269 PFGHSPTMPYILQKSGFKNMLIQRTHYSVKKELAQQRQLEFLWRQIWDNKGDTALFTHMMPFYSY 333
            |||.|.|.|.:...:||...||.|..|.:|.::.:.::|:|:||.....|....:|||.|..:||
Zfish   148 PFGASATTPVLFALAGFDAHLISRIDYDLKDDMQKNKKLQFVWRGSPTLKEKQEIFTHTMDQFSY 212

  Fly   334 DIP------HTCG---------PDPKVCCQFDFKRMGSF-GLSCPWKVPPRTISDQNVAARSDLL 382
            ..|      :..|         |||        .:.|.: .:|.|       ::.:.|...:..:
Zfish   213 CTPSYIPFSNRSGFYWNGVALFPDP--------PKDGKYPNMSLP-------VTKETVELYAQTM 262

  Fly   383 VDQWKKKAELYRTNVLLIPLGDDFRFKQNTEWDVQRVNYERLFEHINSQA-HFNVQAQFGTLQEY 446
            ||..:.:|:.:|::.:|.|.|.|   ||.....||..|.:.|..:||:.: .:.|..|:.||::|
Zfish   263 VDNIRLRAQWFRSSHVLWPWGCD---KQFYNASVQFSNMDVLMNYINTHSDQYGVTVQYATLKDY 324

  Fly   447 FDAVHQAE-----RAGQAEFPTLSGDFFTYADRSDNYWSGYYTSRPYHKRMDRVLMHYVRAAEML 506
            |..:||..     |..|        ||..|:......|:|:|.||...|.:.|.....:.|:|.|
Zfish   325 FQTLHQTNLSWDVRGNQ--------DFLPYSTEPFQAWTGFYGSRNVLKGVARRASSLLYASESL 381

  Fly   507 -SAWH-SW-DGMARIE---ERLEQARRELSLFQHHDGITGTAKTHVVVDYEQRMQEALKACQMVM 565
             :.:| |: ||..:.|   .:|:..|..:|..|||||||||....|...|.:.:.:.:...:.::
Zfish   382 FTRYHISYPDGPVQREWALSKLKALRWAVSEVQHHDGITGTESPKVADMYMEHLLQGMMGAEELL 446

  Fly   566 QQSVYRLLTKPSIYSPDFSFSYFTLDDSRWPGSGVEDSRTTIILGEDILPSKHVVMHNTLPHWRE 630
             .:::.|   |...|.|..             ..::::.||.....:.:|.:|:.::|.|.....
Zfish   447 -AAIFLL---PQTLSNDIY-------------DQIKNTPTTARTDSENVPEQHIFVYNPLAWNIS 494

  Fly   631 QLVDFYVSSPFVSVTDLANNPVEAQVSPVWSWHHDTLTKTIHPQGSTTKYRIIFKARVPPMGLAT 695
            ..|:..|......|.|.....|.||:.|              ...|:|.|.:.|...:..:....
Zfish   495 TYVNVSVQYAMAVVLDDDGKAVPAQIQP--------------SMESSTVYDLFFVVELGGLQYRK 545

  Fly   696 YVLTISDSKPEHTSYASNL-----LLRKNPTSLPLGQYPEDVKFGDPREISLRVGNGPTLAF-SE 754
            |.:....| |..|..|...     :::.|.|::...:     |.|  |::...:.....|.| .|
Zfish   546 YTVQFPQS-PCDTGSACGATHVAKVVKFNKTNVRQWK-----KTG--RKLLPVLNECYKLMFDQE 602

  Fly   755 QGLLKSIQLTQDSPHVPVHFKFLKYGVRSHGD-RSGA----YLFLPNGPASPVELGQPVVL-VTK 813
            ..||.||........|.|...|.:|  :::|| :||.    |:|..||.|.|..  :.||: :..
Zfish   603 TNLLHSITDRSKKIRVRVQQDFWEY--KANGDVQSGPISDNYIFTANGSAVPAY--KSVVMEIVP 663

  Fly   814 GKLESS---------------------VSVGLPSVVHQTIMRGGAPEIRNLVDIGSLD-NTEIVM 856
            ||:.|.                     |.||...       |.....:.....:|.|: |.|.|.
Zfish   664 GKVISEIRQYFYREEEDANHTYSVVTRVPVGFKG-------RLSCFRLEQSYKVGPLEVNRETVF 721

  Fly   857 RLETHIDSGDIFYTDLNGLQFIKR--RRLDKLPLQANYYPIPSGMFIEDANTRLTLLTGQPLGGS 919
            |..|.:.:....:||.||.|.:||  :......:..||||:....::||.::|:..|:.:..|.:
Zfish   722 RTRTSLQNNRTLFTDNNGYQMMKRTYKGYANNTVARNYYPMVRVAYMEDESSRVVFLSERAHGVA 786

  Fly   920 SLASGELEIMQDRRLASDDERGLGQGVLDN-----KPVL-----------HIYR----------- 957
            ||:.|:||:|..|||.::.|...|..:..|     :|||           .||:
Zfish   787 SLSQGQLEVMLHRRLWNNQEWNQGYNLTLNDSSVVRPVLWMMLGSPDSLSSIYQQEAVELQHRPV 851

  Fly   958 -LVLEKVNNCVRPSE------LHPAGYLTSAAHKASQSLLDPLDKFIFAENEWIGAQGQFGGDHP 1015
             :.:::....:...|      :||. .|....|  .|||..|         .|     .:..:|.
Zfish   852 VMAIDQPQKLLNQRETFSGPSVHPV-VLPQNLH--MQSLSIP---------GW-----NYSPEHS 899

  Fly  1016 SAREDLDVSVMRRLTKSSAKTQRVGYVLHRTNLMQCGTPEEHTQKL-----DVCHLLPNVARCER 1075
            |..::          ||.....|:  :|..|:|.:.|.....:|..     :|...:..|::.:.
Zfish   900 SGGDE----------KSEVNFDRI--LLRITHLYEEGESPVLSQPTTINLKEVMQGIGKVSKVQE 952

  Fly  1076 TTLTFLQNLEHL 1087
            .:||...|:..|
Zfish   953 CSLTGTWNISDL 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Man-IIa	NP_001262413.1	GH38N_AMII_GMII_SfManIII_like	144..483	CDD:212120	107/361 (30%)
		Alpha-mann_mid	478..554	CDD:214875	29/81 (36%)
		Glyco_hydro_38C	744..1103	CDD:285047	96/414 (23%)
man2b2	XP_001337519.3	PLN02701	20..1002	CDD:178304	262/1050 (25%)
man2b2	XP_001337519.3	GH38-57_N_LamB_YdjC_SF	23..348	CDD:330225	104/350 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1959
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810