DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aduk and AT2G37840

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_850285.1	Gene:	AT2G37840 / 818361	AraportID:	AT2G37840	Length:	733	Species:	Arabidopsis thaliana

Alignment Length:	555	Identity:	156/555 - (28%)
Similarity:	263/555 - (47%)	Gaps:	138/555 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ITDFEILEKLGAGSYATVYKARHKKQRTYHAIKYVEMSTLSQTSRENLITEIRLLRELKHKYIVT 70
            :.|:.:..::|:||::.|::|||:...|..|||.:.|..|::..:|:|::||.:||.:.|..|:.
plant     9 VGDYLVGRQIGSGSFSVVWEARHRVDGTEVAIKEIAMDRLNKKLQESLMSEIFILRRINHPNIIR 73

  Fly    71 LQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQ 135
            |.|.......:::|||||..|:||.:::....:||:|.::|::||||.:|.:|.|::.|.|||||
plant    74 LIDMIKSPGKVHLVLEYCKGGDLSVYVQRHGIVPEATAKHFMQQLAAGLQVLRDNNIIHRDLKPQ 138

  Fly   136 NLLLTRGANNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIVRKHQYDAKADLWSIGVILYE 200
            ||||:...|:..||:||||||:.|:...:.:.|.||||||||||::..:|||||||||:|.||::
plant   139 NLLLSTNENDADLKIADFGFARSLQPRGLAETLCGSPLYMAPEIMQLQKYDAKADLWSVGAILFQ 203

  Fly   201 CLFGKAPYSSRTIEELLLRIRKAEAITLPPNAR-ISNECHDLLRRLLAHEPTARISFADFFAHPF 264
            .:.|:.|::..:..:||..|.::..:..|.:.| :|.:|.||.::||...|..|::|.:||.|||
plant   204 LVTGRTPFTGNSQIQLLQNIIRSTELHFPGDCRDLSLDCIDLCQKLLRRNPVERLTFEEFFNHPF 268

  Fly   265 L-DLKTFPTEHTLQKAIDLVTQ----ACAYDEKHNYKEAYYLYCSALQYFV----------PLIT 314
            | |.:::...   :..:.|.|.    :.......|.:|:....|  |.:.:          |...
plant   269 LSDRQSYDFS---RSRLGLRTMDGFLSSGSSPSRNMEESSQEDC--LPFLLDDDSSGPEGSPSYL 328

  Fly   315 EETDATK------------RLALRNRALSYTKRA-------EEIKNCIIEDEYRMLAE-----RQ 355
            ::|.:.|            |..:.:..|.:|:..       ::::|    |.:|...:     |.
plant   329 KKTSSMKSSSGIKVDTRIERKEVESSPLKHTELTSGYSSFNQKVEN----DRFRFETQINSDRRN 389

  Fly   356 RQAATAAT-----------------------------------------------ANQEP----- 368
            |:..|..|                                               .:|.|
plant   390 RREPTGLTDSRSLIAPGRVDDSQDSMDQDFVLVSGPPVDMPSSSSSSSKPYNFPFKSQSPPVELF 454

  Fly   369 ----SSATQVPAAQPSSSRVAEMLEPDSRYKQLYALSNSSPSMKTG-LEIG-------------- 414
                ||...:|....:|:.:.:....||:|        |:||...| |::|
plant   455 NRSISSTAPMPIIGATSNSIGQFGSLDSQY--------SAPSTSHGSLDLGDAFEQPSTHSLTRI 511

  Fly   415 ---RK-----GELYLYER-KLDAALESYTSALGIL 440
               ||     .|| :||| :.|..||:::..|.||
plant   512 RSLRKYAATIAEL-VYERIESDKHLEAFSIQLAIL 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	105/256 (41%)
		PKc_like	13..264	CDD:304357	104/251 (41%)
		MIT_2	274..348	CDD:239147	14/106 (13%)
		MIT	407..472	CDD:282117	16/58 (28%)
AT2G37840	NP_850285.1	STKc_ATG1_ULK_like	18..268	CDD:270911	104/249 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	222	1.000	Domainoid score	I706
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003680
OrthoInspector	1	1.000	-	-		otm3171
orthoMCL	1	0.900	-	-		OOG6_101938
Panther	1	1.100	-	-	O	PTHR24348
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.810