DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aduk and Atg1

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001163433.1	Gene:	Atg1 / 39454	FlyBaseID:	FBgn0260945	Length:	855	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	146/508 - (28%)
Similarity:	236/508 - (46%)	Gaps:	86/508 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ITDFEILEK--LGAGSYATVYKARHKKQRTYHAIKYVEMSTLSQTSRENLI-TEIRLLR---ELK 64
            :.::|...|  ||.|::|.|||.||:|:....|||.:  :...|...:||: .||::|:   ||.
  Fly     4 VGEYEYSSKDMLGHGAFAVVYKGRHRKKHMPVAIKCI--TKKGQLKTQNLLGKEIKILKELTELH 66

  Fly    65 HKYIVTLQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSH 129
            |:.:|.|.|.......:.:|:||||.|:|:.::..|..|.|.|.|.||.|||.|::.:....:.|
  Fly    67 HENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVH 131

  Fly   130 FDLKPQNLLLTR-------GANNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIVRKHQYDA 187
            .||||||:||:.       ..:.::||:||||||:.|..|.:...|.|||:|||||::...|||:
  Fly   132 RDLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDS 196

  Fly   188 KADLWSIGVILYECLFGKAPYSSRTIEELLLRIRKAEAITLPPN--ARISNECHDLLRRLLAHEP 250
            ||||||:|.|:|:||.||||:.::|..|  |:....:...|.|.  :.:|.:..|||..||....
  Fly   197 KADLWSLGTIVYQCLTGKAPFYAQTPNE--LKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNS 259

  Fly   251 TARISFADFFAHPFLDLK----------------------------------------TFPTEHT 275
            ..|||:..||.|.||..|                                        ..|.:..
  Fly   260 KDRISYESFFVHRFLQGKKAAVSPGEPSQAANLRRRVSKSGVLPVDMPPLGGTPPAKAKSPLQQQ 324

  Fly   276 LQKAIDLVTQACAYDEKHNYKEAYY-----------LYCSALQYFVPLITEETDATKRLALRNRA 329
            |::.:.||..|....::...:||..           ..|:.:.....|...|.:        :.:
  Fly   325 LEQELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENN--------SGS 381

  Fly   330 LSYTKRAEEI----KNCIIEDEYRMLAERQRQAATAATANQEPSSATQVPAAQPSSSRVAEMLE- 389
            .|..:.:::.    || :.||:.:.||:.|.|.|:.....|:..:.:..|  :|||..::|...
  Fly   382 CSSHEDSDDFVLVPKN-LPEDQRQGLAQVQAQPASGGQRPQQQQNQSSPP--RPSSLPISEPKPV 443

  Fly   390 PDSRYKQLYALSNSSPSMKTGLEIGRKGELYLYERKLDAALESYTSALGILVP 442
            |....:|:......:.:...|.:|.|...:.:.:.:.|....|.:|.:..:.|
  Fly   444 PAPARRQVARPGPLTVATLGGQQIPRSQPISVKQPRPDQRKSSVSSDINSISP 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	108/270 (40%)
		PKc_like	13..264	CDD:304357	107/265 (40%)
		MIT_2	274..348	CDD:239147	14/88 (16%)
		MIT	407..472	CDD:282117	7/36 (19%)
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	107/268 (40%)
		STKc_ULK1_2-like	15..273	CDD:271022	106/261 (41%)
		DUF3543	638..844	CDD:288883
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444963
Domainoid	1	1.000	166	1.000	Domainoid score	I809
eggNOG	1	0.900	-	-		E1_KOG0595
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46828
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24348
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.880