Protein Alignment Ada and ADA2

DIOPT Version :10

• Sequence 1: NP_649866.1
• Gene: Ada / 41092
• FlyBaseID: FBgn0037661
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: NP_001269154.1
• Gene: ADA2 / 51816
• HGNCID: 1839
• Length: 511
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 82/338 - (24%)
• Similarity: 142/338 - (42%)
• Gaps: 68/338 - (20%)

  Fly    39 KDFLKLCAHFSRFEKDMDACFEKFAFV--H-ELTSTREGL---RFATEL---------------- 81
            :|:.|...:.:.|:   |:....|..|  | |:..|.:.:   :|.|..
Human   166 EDYRKRVQNVTEFD---DSLLRNFTLVTQHPEVIYTNQNVVWSKFETIFFTISGLIHYAPVFRDY 227

  Fly    82 ---AIRDFAEDNVQYVEMR---------TTPKANENYSRRDYLQIVIDAIKAASETYPE-ITVKL 133
               ::::|.||||.|:|:|         :....:|.:|.:.|.::....:    ||:|| |.:|:
Human   228 VFRSMQEFYEDNVLYMEIRARLLPVYELSGEHHDEEWSVKTYQEVAQKFV----ETHPEFIGIKI 288

  Fly   134 LPSINRAEPVDVAEETVSLAVELARAHPNLILGIDLSGNPGKGR-FSDFAPILAQARDKGLKLA- 196
            :.|.:|::.|.|..|::.:|:.|....|.::.|.||.|:...|. ..|:...|......|:||.
Human   289 IYSDHRSKDVAVIAESIRMAMGLRIKFPTVVAGFDLVGHEDTGHSLHDYKEALMIPAKDGVKLPY 353

  Fly   197 -IHCAEIE-----NPSEVKEMLHFGMSRCGHGTFLT--PEDIGQLKQRNIAIECCLTSNVKSGTV 253
             .|..|.:     ....:.:.|....:|.|||..|:  |.......:::|.||.|..||.....|
Human   354 FFHAGETDWQGTSIDRNILDALMLNTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLV 418

  Fly   254 PSLEEHHLKRIMEADAPKVICTDDSGVFDTT-LTKEFLIAAETF----GL-----TREQCIDLTL 308
            ..|..|.:..:|....|.||.:||..:|... |:.:|.   |.|    |:     |.:|   |.:
Human   419 SDLRNHPVATLMATGHPMVISSDDPAMFGAKGLSYDFY---EVFMGIGGMKADLRTLKQ---LAM 477

  Fly   309 EAVHHSFASEQEQ 321
            .::.:|...|.|:
Human   478 NSIKYSTLLESEK 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ada	NP_649866.1	ADA_AMPD	8..327	CDD:238250	82/338 (24%)
ADA2	NP_001269154.1	adm_rel	30..509	CDD:273620	82/338 (24%)
		Dimerization	30..100
		PRB domain	127..185		4/21 (19%)