Protein Alignment Ada and AMPD3

DIOPT Version :10

• Sequence 1: NP_649866.1
• Gene: Ada / 41092
• FlyBaseID: FBgn0037661
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: NP_000471.1
• Gene: AMPD3 / 272
• HGNCID: 470
• Length: 776
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 82/435 - (18%)
• Similarity: 138/435 - (31%)
• Gaps: 131/435 - (30%)

  Fly     1 MEQF--LKGLP--------KVELHAHLNGSLGIKSLCDLGERLYGT------SCKDFLKLC---- 45
            |.:|  ||..|        ||:.|.|....:..|.|....:..|.|      :.|...|:.
Human   303 MSEFKELKSNPHRDFYNVRKVDTHIHAAACMNQKHLLRFIKHTYQTEPDRTVAEKRGRKITLRQV 367

  Fly    46 ---AHFSRFEKDMDAC-----------FEKF---------AFVHELTSTREG-------LRFATE 80
               .|...::..:|:.           |:||         :.:.:|....|.       .|...|
Human   368 FDGLHMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKE 432

  Fly    81 LAIRDFAEDNVQYVEMR-----TTPKANEN----------YS--RRDYLQI--VIDAIKAASETY 126
            :| |:..|...||.|.|     .:|:...|          ||  .|..:|:  :.|..::.
Human   433 VA-RELEESKYQYSEPRLSIYGRSPEEWPNLAYWFIQHKVYSPNMRWIIQVPRIYDIFRSK---- 492

  Fly   127 PEITVKLLPSINRAEPVDVAEETVSLAVELARAHP----------NLILGIDLSGNPGK---GRF 178
                 ||||:..:      ..|.:.|.:..|..:|          ..:.|.|...:..|   ..|
Human   493 -----KLLPNFGK------MLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMF 546

  Fly   179 SDFAP-------------------------ILAQ-ARDKGLKLAI---HCAEIENPSEVKEMLHF 214
            ||.:|                         :|.. .|::||...:   ||.|..:.:.:.... .
Human   547 SDKSPNPDVWTSEQNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAF-L 610

  Fly   215 GMSRCGHGTFLTPEDIGQLKQRNIAIECCLTSNVKSGTVPSLEEHHLKRIMEADAPKVICTDDSG 279
            ......||..|....:.|.......|...::....:.......::.|:..:.......:.|||..
Human   611 TADNISHGLLLKKSPVLQYLYYLAQIPIAMSPLSNNSLFLEYSKNPLREFLHKGLHVSLSTDDPM 675

  Fly   280 VFDTT---LTKEFLIAAETFGLTREQCIDLTLEAVHHSFASEQEQ 321
            .|..|   |.:|:.|||:.:.|:.....::...:|..|..|.||:
Human   676 QFHYTKEALMEEYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEK 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ada	NP_649866.1	ADA_AMPD	8..327	CDD:238250	78/426 (18%)
AMPD3	NP_000471.1	AMP_deaminase	137..768	CDD:437158	82/435 (19%)