Protein Alignment Ada and ADA

DIOPT Version :10

• Sequence 1: NP_649866.1
• Gene: Ada / 41092
• FlyBaseID: FBgn0037661
• Length: 337
• Species: Drosophila melanogaster
• Sequence 2: NP_000013.2
• Gene: ADA / 100
• HGNCID: 186
• Length: 363
• Species: Homo sapiens
• Alignment Length: 356
• Identity: 87/356 - (24%)
• Similarity: 145/356 - (40%)
• Gaps: 58/356 - (16%)

  Fly     9 PKVELHAHLNGSLGIKSLCDLGER----LYGTSCKDFLKLCA---------HFSRFEKDMDACFE 60
            ||||||.||:||:..:::...|.|    |...:.:..|.:..         ..::|:..|.|
Human    10 PKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPA--- 71

  Fly    61 KFAFVHELTSTREGL-RFATELAIRDFAEDNVQYVEMRTTPKANENYSRRDYLQIVIDAI---KA 121
                   :...||.: |.|.|. :...|::.|.|||:|.:|....|..        ::.|   :|
Human    72 -------IAGCREAIKRIAYEF-VEMKAKEGVVYVEVRYSPHLLANSK--------VEPIPWNQA 120

  Fly   122 ASETYPEITVKLLPSINRAEPVDVAEETVSL-------------AVELARAH-PNLILGIDLSGN 172
            ..:..|:..|.|:....:....|...:..|:             .|||.:.: ...::.|||:|:
Human   121 EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGD 185

  Fly   173 ---PGKGRFSDFAPILAQARDKGLKLAIHCAEIENPSEVKEMLH-FGMSRCGHGTFLTPED---I 230
               ||............:|...|:...:|..|:.:...|||.:. ....|.||| :.|.||   .
Human   186 ETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHG-YHTLEDQALY 249

  Fly   231 GQLKQRNIAIECCLTSNVKSGTVPSLEEHHLKRIMEADAPKVICTDDSGVFDTTLTKEFLIAAET 295
            .:|:|.|:..|.|..|:..:|......||.:.|:....|...:.|||..:|.:||..::.:....
Human   250 NRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRD 314

  Fly   296 FGLTREQCIDLTLEAVHHSFASEQEQIQMAD 326
            .|.|.|:...|.:.|...||..|.|:.::.|
Human   315 MGFTEEEFKRLNINAAKSSFLPEDEKRELLD 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ada	NP_649866.1	ADA_AMPD	8..327	CDD:238250	87/356 (24%)
ADA	NP_000013.2	A_deaminase	10..350	CDD:425964	87/356 (24%)
		Required for binding to DDP4. /evidence=ECO:0000269|PubMed:15016824	126..143		3/16 (19%)