Protein Alignment tgo and Bmal1

DIOPT Version :10

• Sequence 1: NP_731308.1
• Gene: tgo / 41084
• FlyBaseID: FBgn0264075
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: XP_017444554.1
• Gene: Bmal1 / 29657
• RGDID: 62003
• Length: 633
• Species: Rattus norvegicus
• Alignment Length: 540
• Identity: 202/540 - (37%)
• Similarity: 296/540 - (54%)
• Gaps: 61/540 - (11%)

  Fly    14 SRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGNTSSDGTY 78
            :||.|.:||:|||:||.::|.||:.:||||:|::||.||||:|||||.|||.|||..|..::..|
  Rat    80 AREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANY 144

  Fly    79 KPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDRE 143
            ||:||:|.|||||||.|||||||||.||.|::::||:||..:|||:|:|..|.||::::||.|..
  Rat   145 KPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIA 209

  Fly   144 KIREQLSTQESQNAGRILDLKSG-TVKKEGHQSSMRLSMGARRGFICRMRVG----NVNPESMVS 203
            |::||||:.::....|::|.|:| .||.:......||..||||.|.|||:..    .|..:...|
  Rat   210 KVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARRSFFCRMKCNRPSVKVEDKDFAS 274

  Fly   204 GHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSSHC---CLVAIGR 265
            ....:...|.|         :..:|.|||:|:||||    .|.::.|.:..:..|   |||||||
  Rat   275 TCSKKKADRKS---------FCTIHSTGYLKSWPPT----KMGLDEDSEPDNEGCNLSCLVAIGR 326

  Fly   266 LQVTSTAANDMSGS--NNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHPEDQS 328
            |. :......::|.  ....|:::|||:||||.|||||...||.|.|.||||..||::||.:|..
  Rat   327 LH-SHMVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIG 390

  Fly   329 HMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNS--SGKTMHG 391
            |:.|...|||:.:.::.:..|:.:.|:..::.||::.::|:||:|.||||||.||:  ....:.|
  Rat   391 HLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEG 455

  Fly   392 A----PLDAAAAHTPEQVQQQQQ---QEQHVYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAM 449
            .    |...|:.|:.:.:....:   :..|..|...||  ..|.....:|....:.:.:.|.:
  Rat   456 GDPTFPQLTASPHSMDSMLPSGEGGPKRTHPTVPGIPG--GTRAGAGKIGRMIAEEIMEIHRI-- 516

  Fly   450 QAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPLAKIPKSGTSPTPVAPNSWAALRP 514
                      :...|.|..::|:..|........|.||    .||...||...|.     |.|.|
  Rat   517 ----------RGSSPSSCGSSPLNITSTPPPDASSPGG----KKILNGGTPDIPS-----AGLLP 562

  Fly   515 QQQQQQQQPVTEGYQYQQTS 534
            .|.|:     |.||.|..:|
  Rat   563 GQAQE-----TPGYPYSDSS 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_731308.1	bHLH-PAS_ARNT	9..74	CDD:381517	36/59 (61%)
		PAS	90..154	CDD:214512	36/63 (57%)
		PAS_11	282..384	CDD:464214	46/101 (46%)
Bmal1	XP_017444554.1	bHLH-PAS_ARNTL_PASD3	74..137	CDD:381444	35/56 (63%)
		PAS	156..215	CDD:214512	33/58 (57%)
		PAS_11	346..448	CDD:464214	47/101 (47%)