DRSC/TRiP Functional Genomics Resources

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Protein Alignment tgo and Hif1a

DIOPT Version :10

Sequence 1:NP_731308.1 Gene:tgo / 41084 FlyBaseID:FBgn0264075 Length:642 Species:Drosophila melanogaster
Sequence 2:XP_006240258.1 Gene:Hif1a / 29560 RGDID:61928 Length:828 Species:Rattus norvegicus


Alignment Length:611 Identity:141/611 - (23%)
Similarity:248/611 - (40%) Gaps:147/611 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 QDKERFAS---RENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKA--L 66
            :.|.|.:|   :|...:..|.||:|.:....||:..:|....::...||.:::|:.:::::.  |
  Rat     9 EKKNRMSSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKL 73

  Fly    67 RGTGNTSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGT 131
            ...|:...:...|      .::....|:|.|||:.|:: |.|.:||:||:|...:..||.:..|.
  Rat    74 LDAGDLDIEDEMK------AQMNCFYLKALDGFVMVLT-DDGDMIYISDNVNKYMGLTQFELTGH 131

  Fly   132 SLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNV 196
            |:::..||.|.|::||.|:.            ::|.|:|...|::       :|.|..||:.   
  Rat   132 SVFDFTHPCDHEEMREMLTH------------RNGPVRKGKEQNT-------QRSFFLRMKC--- 174

  Fly   197 NPESMVS-GHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSSHCCL 260
               ::.| |....:|          ...:.|:||||:|..:..:...|....::     ....||
  Rat   175 ---TLTSRGRTMNIK----------SATWKVLHCTGHIHVYDTSSNQPQCGYKK-----PPMTCL 221

  Fly   261 VAI-------GRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKIC 318
            |.|       ..:::..          :...|::||::|.||::.|:|:..::||.|.||||:..
  Rat   222 VLICEPIPHPSNIEIPL----------DSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSI 276

  Fly   319 YDFFHPEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTN 383
            |:::|..|..|:.::...:. .|||:.:..||..||...|||:.|||....|....:.:.|||.|
  Rat   277 YEYYHALDSDHLTKTHHDMF-TKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVN 340

  Fly   384 --SSGKTMHGAPLDAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYARREL-TPVGSATNDGMY--- 442
              .||...|            :.:...||.|.  .::.....|....:| |.|.|.....::   
  Rat   341 YVVSGIIQH------------DLIFSLQQTES--VLKPVESSDMKMTQLFTKVESEDTSCLFDKL 391

  Fly   443 --QTHMLAMQAP---------------TPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYS------ 484
              :...|.:.||               |..:.||.:..|          .|:....|.|      
  Rat   392 KKEPDALTLLAPAAGDTIISLDFGSDDTETEDQQLEDVP----------LYNDVMFPSSNEKLNI 446

  Fly   485 --AGGPSPLAKIPKSGTSPTPVAPNSWAALRPQQQQQQQQPVTEGYQYQQTSPARSPSGPTYTQL 547
              |..|.|.::.||...|....|.|...||:     .:..|.:.|..:........|:.|:    
  Rat   447 NLAMSPLPASETPKPLRSSADPALNQEVALK-----LESSPESLGLSFTMPQIQDQPASPS---- 502

  Fly   548 SAGNGNRQQAQPGAYQAGPPPPPNAP 573
               :|:.:|:.         |.||:|
  Rat   503 ---DGSTRQSS---------PEPNSP 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tgoNP_731308.1 bHLH-PAS_ARNT 9..74 CDD:381517 16/69 (23%)
PAS 90..154 CDD:214512 24/63 (38%)
PAS_11 282..384 CDD:464214 37/103 (36%)
Hif1aXP_006240258.1 bHLH-PAS_HIF1a_PASD8 14..84 CDD:381570 14/69 (20%)
PAS 94..149 CDD:214512 23/55 (42%)
PAS_3 255..340 CDD:430001 30/85 (35%)
HIF-1 551..580 CDD:463274
HIF-1a_CTAD 791..827 CDD:430212
Blue background indicates that the domain is not in the aligned region.

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