Protein Alignment tgo and EPAS1

DIOPT Version :10

• Sequence 1: NP_731308.1
• Gene: tgo / 41084
• FlyBaseID: FBgn0264075
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: XP_011531000.1
• Gene: EPAS1 / 2034
• HGNCID: 3374
• Length: 883
• Species: Homo sapiens
• Alignment Length: 783
• Identity: 194/783 - (24%)
• Similarity: 294/783 - (37%)
• Gaps: 231/783 - (29%)

  Fly     7 QDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKALRGTGN 71
            ::|.|.|:|   |     ||:|.|....||:..:|...:::...||.:|:|:|::.::..:...:
Human    29 KEKSRDAAR---C-----RRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSS 85

  Fly    72 TSSDGTYKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWYGTSLYEH 136
            ..|:...:..  .||::.:|.|:|.:||:.||:.| |.:|::|::::..:..||.:..|.|:::.
Human    86 VCSENESEAE--ADQQMDNLYLKALEGFIAVVTQD-GDMIFLSENISKFMGLTQVELTGHSIFDF 147

  Fly   137 IHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVGNVNPESM 201
            .||.|.|:|||.||.:..          ||..||.       ..|...|.|..||:....|
Human   148 THPCDHEEIRENLSLKNG----------SGFGKKS-------KDMSTERDFFMRMKCTVTN---- 191

  Fly   202 VSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIK---NWPPTDMF-----PNMHMERDVDDMSSHC 258
             .|....||          ...:.|:||||.:|   |.||.:..     |.:           .|
Human   192 -RGRTVNLK----------SATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLL-----------SC 234

  Fly   259 CLVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFH 323
            .::....:|..|    .|....:...|::||:||.|||:.|.|:..::||.|.||||:..|:|:|
Human   235 LIIMCEPIQHPS----HMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYH 295

  Fly   324 PEDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTN----- 383
            ..|..:|.:| .|.|..|||:.|..||..||:..||||.||.....||...:.:.|:|.|
Human   296 ALDSENMTKS-HQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSE 359

  Fly   384 -----------------------------SSGKTMHGAP------LDAAAAHTPEQVQQ------ 407
                                         ||||   ||.      |.......||::.|
Human   360 IEKNDVVFSMDQTESLFKPHLMAMNSIFDSSGK---GAVSEKSNFLFTKLKEEPEELAQLAPTPG 421

  Fly   408 ----------QQQQEQHVYVQA--APGVDYARRELTPVGSATNDGMYQTHMLAMQAPTPQQQQQQ 460
                      |..:|...|.:|  .|...:| .||....:.:..|......:. ||..|......
Human   422 DAIISLDFGNQNFEESSAYGKAILPPSQPWA-TELRSHSTQSEAGSLPAFTVP-QAAAPGSTTPS 484

  Fly   461 QQRPGSAQTTPVG--------------------YTYDT------------------THSPY-SAG 486
            .....|:.:||..                    :..||                  |.:|| ...
Human   485 ATSSSSSCSTPNSPEDYYTSLDNDLKIEVIEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMD 549

  Fly   487 GP----SP-------LAKIPKSGTSP--------------TPVAPNSWAALRPQQQQ-------Q 519
            |.    ||       ||:.|:|  :|              .||||:|...|...|||       .
Human   550 GEDFQLSPICPEERLLAENPQS--TPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEP 612

  Fly   520 QQQPVTEGYQYQQTSPARSP--SGPTYTQLSAGNGNRQQAQPGAYQAGPPPPPNAPGMWDW---- 578
            :.:|::..: :...|.|..|  .|...|.||: .|.|...|      .||.||...|...|
Human   613 EHRPMSSIF-FDAGSKASLPPCCGQASTPLSS-MGGRSNTQ------WPPDPPLHFGPTKWAVGD 669

  Fly   579 ---QQAGGHPHPPHPTAHPHHPHAHPGGPAGAG-------QPQGQEFSDMLQM---LDHTPTTFE 630
               :..|..|..| |.:.||..........|.|       .|.....|:.|::   |::....|:
Human   670 QRTEFLGAAPLGP-PVSPPHVSTFKTRSAKGFGARGPDVLSPAMVALSNKLKLKRQLEYEEQAFQ 733

  Fly   631 DLN 633
            ||:
Human   734 DLS 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_731308.1	bHLH-PAS_ARNT	9..74	CDD:381517	17/64 (27%)
		PAS	90..154	CDD:214512	24/63 (38%)
		PAS_11	282..384	CDD:464214	44/135 (33%)
EPAS1	XP_011531000.1	bHLH-PAS_HIF2a_PASD2	22..87	CDD:381571	17/65 (26%)
		PAS	99..160	CDD:214512	22/61 (36%)
		PAS_3	267..354	CDD:430001	37/87 (43%)
		HIF-1	530..562	CDD:463274	6/31 (19%)
		HIF-1a_CTAD	846..882	CDD:430212