Protein Alignment tgo and aha-1

DIOPT Version :10

• Sequence 1: NP_731308.1
• Gene: tgo / 41084
• FlyBaseID: FBgn0264075
• Length: 642
• Species: Drosophila melanogaster
• Sequence 2: NP_001251327.1
• Gene: aha-1 / 172889
• WormBaseID: WBGene00000095
• Length: 453
• Species: Caenorhabditis elegans
• Alignment Length: 459
• Identity: 211/459 - (45%)
• Similarity: 279/459 - (60%)
• Gaps: 49/459 - (10%)

  Fly     1 MDEANIQDKERFASRENHCEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVAHMKA 65
            |::...::||||| ||||.|||||||||||.||.||::|||.|::|.|||||||||||||:|||.
 Worm    33 MEDEMGENKERFA-RENHSEIERRRRNKMTHYINELAEMVPQCASLGRKPDKLTILRMAVSHMKG 96

  Fly    66 LRGTGNTSSDGT-YKPSFLTDQELKHLILEAADGFLFVVSCDSGRVIYVSDSVTPVLNYTQSDWY 129
            :|  |:|:.|.| |||||||||||||||||||:||||||.|.:|:|:||:||:|||||..|.||.
 Worm    97 IR--GHTAQDETSYKPSFLTDQELKHLILEAANGFLFVVCCQTGKVLYVADSITPVLNLKQEDWL 159

  Fly   130 GTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKEGHQSSMRLSMGARRGFICRMRVG 194
            ..:|.|.|||||::|||:||...| .:..::||||||:||:||  :|.|:.|..|||||||||||
 Worm   160 QRNLNELIHPDDQDKIRDQLCGSE-VSVNKVLDLKSGSVKREG--ASTRVHMSCRRGFICRMRVG 221

  Fly   195 NVNPESMVSGHLNRLKQRNSLGPSRDGTNYAVVHCTGYIKNWPPTDMFPNMHMERDVDDMSSHCC 259
            .:.|       |:||:.|..|. ...|.||.|:||||||||.||..:           :..:..|
 Worm   222 ALEP-------LHRLRNRRPLF-QHAGQNYVVMHCTGYIKNAPPQGI-----------NAPASSC 267

  Fly   260 LVAIGRLQVTSTAANDMSGSNNQSEFITRHAMDGKFTFVDQRVLNILGYTPTELLGKICYDFFHP 324
            ||||.||||.|........|.||  |..|.:.|||.||:|.||.:::|.:..:|:|:..::..||
 Worm   268 LVAIARLQVASMPVCADPTSTNQ--FSVRVSEDGKMTFIDARVSDLIGLSSDQLIGRYWWNLAHP 330

  Fly   325 EDQSHMKESFDQVLKQKGQMFSLLYRARAKNSEYVWLRTQAYAFLNPYTDEVEYIVCTNSSGKTM 389
            .|:..:::||..:|..:....::..|.   :::|:.....||.|:|||:::.||:|.|:..
 Worm   331 ADEKTLQDSFVALLSDQPMRINIRVRT---STDYIPCTVSAYKFMNPYSEQFEYVVATHQI---- 388

  Fly   390 HGAPL-DAAAAHTPEQVQQQQQQEQHVYVQAAPGVDYARRELTPVGSATNDGMYQTHMLAMQAPT 453
              ||. |.....|...|.|.|..|......|...|||        |.:::.|....   |..||.
 Worm   389 --APQEDINNWVTAPTVPQPQASEFGELGGAPSAVDY--------GQSSSGGWRPE---AQGAPQ 440

  Fly   454 PQQQ 457
            .|.|
 Worm   441 AQWQ 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tgo	NP_731308.1	bHLH-PAS_ARNT	9..74	CDD:381517	48/64 (75%)
		PAS	90..154	CDD:214512	40/63 (63%)
		PAS_11	282..384	CDD:464214	32/101 (32%)
aha-1	NP_001251327.1	bHLH-PAS_ARNT	41..105	CDD:381517	48/66 (73%)
		PAS	120..179	CDD:214512	38/58 (66%)
		PAS_11	288..393	CDD:464214	35/115 (30%)