Protein Alignment pyd and TJP2

DIOPT Version :10

• Sequence 1: NP_001246998.1
• Gene: pyd / 41062
• FlyBaseID: FBgn0262614
• Length: 2395
• Species: Drosophila melanogaster
• Sequence 2: NP_001163887.1
• Gene: TJP2 / 9414
• HGNCID: 11828
• Length: 1221
• Species: Homo sapiens
• Alignment Length: 1316
• Identity: 396/1316 - (30%)
• Similarity: 581/1316 - (44%)
• Gaps: 344/1316 - (26%)

  Fly   246 WEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGVSL 310
            ||.:||.:.:....|||||||||||||||.||:.||.:||||.||||:..||.|||::.|||..:
Human    60 WEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPM 124

  Fly   311 ENVEYATAVQVLRDSGNTVQLVVKR-----------RVPLNPINAAGAVQHQHS----HSLSSVG 360
            |:|.::.|||.||.||....:||||           ..||:..:.|..|..:..    .|..|..
Human   125 EDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPLDQDDRAFEVMDEFDGRSFRSGYSER 189

  Fly   361 LMANGSGG----------------VAPTPITSLSQPNSLNSSL----------VQNASSGQ---- 395
            ...|..||                .|.:....||:..|...||          .::.|.|:
Human   190 SRLNSHGGRSRSWEDSPERGRPHERARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLER 254

  Fly   396 ----------------------------------------------------------------- 395
                                                                             
Human   255 GLDHDFGPSRDRDRDRSRGRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSRE 319

  Fly   396 ----------------PIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDII 444
                            ||.|.|.|....::||:.||.::||||::   |..|.....:|.|||||
Human   320 HPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMT---RTGLATKDGNLHEGDII 381

  Fly   445 TRIHNTNCGDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQP 509
            .:|:.| ..:.|||.:|:|:|:..:.:|.|||||| :.||.::..:||:|.|
Human   382 LKINGT-VTENMSLTDARKLIEKSRGKLQLVVLRD-SQQTLINIPSLNDSDS------------- 431

  Fly   510 QVSGCSSSNNN-------LEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNLTPRG 567
            ::...|...:|       ....|.......||:.|..:|.:|            .|..|.|:..|
Human   432 EIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSR------------EDTPSRLSRMG 484

  Fly   568 RSRGPIMDGVSLQQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFYSSRRQLYEERQSAE 632
            .:..|..   |...:...|.|...:.....|.|..|.|:     ||...|.   |...|:.....
Human   485 ATPTPFK---STGDIAGTVVPETNKEPRYQEDPPAPQPK-----AAPRTFL---RPSPEDEAIYG 538

  Fly   633 P--RFISFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAV 695
            |  :.:.|:|..|||:||.|||:.||||..:|.|:.|..:||..||:|||||..|..|:.||:||
Human   539 PNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAV 603

  Fly   696 LFLLSLQ--DRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTL 758
            |:||.:.  :.:.::.|...:.|.:::...|||||.|::||.|:..:...:||..|:||||:|||
Human   604 LYLLEIPKGEMVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTL 668

  Fly   759 HNGVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGNFFRRR--RSTH 821
            ::|.:|:|..::||   .|:::|:||||||||::|:.| ||.:.  ||.: |.:|:|.|  ||..
Human   669 YDGKLGNWLAVRIG---NELEKGLIPNKSRAEQMASVQ-NAQRD--NAGD-RADFWRMRGQRSGV 726

  Fly   822 RRSKSLSRENWDDVVFSDSIS-KFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFST 885
            :::...|||:...||   |:| ||||||||:||..||.||||||||::|:|.|:||.:.||.|.|
Human   727 KKNLRKSREDLTAVV---SVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQT 788

  Fly   886 PLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHVI 950
             .:.:.|.|.:.....:|||:.:|.::::.||||||:||.|||.|||.|::|:|||...||:..:
Human   789 -AKTEPKDAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGV 852

  Fly   951 KQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIAL-SDEESWYRKLRDSIDLQQSGAVWMS 1014
            |.:|..|...::|||:||.:|..||::..:|:|:..|.| |..:||:..|:|:|..||..|||:|
Human   853 KTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWVS 917

  Fly  1015 ESKPVESLSDD------FLFPMTTSRLSYASSPESDLELSPGPSASLSLGNLPQ-----LVKA-- 1066
            |.| :|.:.||      :|..|....||..|...||.|.:.|...:.:...|.:     ||.:
Human   918 EGK-MEGMDDDPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELDEPAEEPLVSSIT 981

  Fly  1067 -SSDP-----SI-------------ATNQDNLDRDRDIIGEGLPPPYTVPYDHAVPANPNRRQTM 1112
             ||:|     ||             |.:.|.| ||..      |||...| :.......|:.::.
Human   982 RSSEPVQHEESIRKPSPEPRAQMRRAASSDQL-RDNS------PPPAFKP-EPPKAKTQNKEESY 1038

  Fly  1113 DSSKYSIYGTNVPPQQQQPGVGGDTAAVRPQSLYGINAPDLPPRIDRQSKPGDIPLNTSGSSSRN 1177
            |.||...|.:|             .:||......|.:....||.:  .:||
Human  1039 DFSKSYEYKSN-------------PSAVAGNETPGASTKGYPPPV--AAKP-------------- 1074

  Fly  1178 GTLGRS---------AQERLFGKAVVQDDVQAEYITRNALVGSGAAETLDRQQQQQQQTHASLER 1233
             |.|||         .||   |:.|.:...:.:...::.|......|.:|.:.:.|:..    |.
Human  1075 -TFGRSILKPSTPIPPQE---GEEVGESSEEQDNAPKSVLGKVKIFEKMDHKARLQRMQ----EL 1131

  Fly  1234 QARLNAQLKANGVGAGGGGASTYDSVSSYDSYNNTQMAMQNLGRLGPNAPDDLKSVPNANGRPLP 1298
            |...||::                           ::|.::         .|:.:||....:|.|
Human  1132 QEAQNARI---------------------------EIAQKH---------PDIYAVPIKTHKPDP 1160

  Fly  1299 PTGQSHEYGRTPHDHRSFGGPNDLNRQSSPGRPHYHDMNASRNIDPRNGTPQRPSNLGLESSPRK 1363
            .|.| |...|.|..            |.:|.|| |.|...|...|..            |...|:
Human  1161 GTPQ-HTSSRPPEP------------QKAPSRP-YQDTRGSYGSDAE------------EEEYRQ 1199

  Fly  1364 PLVE--TKTDYGKYSR 1377
            .|.|  .:..||:.:|
Human  1200 QLSEHSKRGYYGQSAR 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ1_ZO1-like	249..335	CDD:467209	48/85 (56%)
		PDZ2_ZO1-like_ds	397..479	CDD:467210	33/81 (41%)
		PDZ3_ZO1-like_domain	632..711	CDD:467211	36/82 (44%)
		SH3_ZO	729..790	CDD:212793	27/60 (45%)
		GuKc	831..1007	CDD:214504	81/177 (46%)
		ZU5	2264..2365	CDD:459941
TJP2	NP_001163887.1	PDZ1_ZO1-like	63..149	CDD:467209	48/85 (56%)
		U2AF_lg	175..>257	CDD:273727	13/81 (16%)
		SF-CC1	214..>305	CDD:273721	8/90 (9%)
		PDZ2_ZO1-like_ds	337..415	CDD:467210	33/81 (41%)
		PDZ3_ZO1-like_domain	540..621	CDD:467211	35/80 (44%)
		SH3_ZO-2	635..697	CDD:212960	31/64 (48%)
		GuKc	731..910	CDD:214504	84/182 (46%)