Protein Alignment: pyd and Tjp3

• Sequence 1: NP_001246998.1
• Gene: pyd
• FlyBaseID: FBgn0262614
• Length: 2395
• Species: Drosophila melanogaster
• Sequence 2: NP_001269025.1
• Gene: Tjp3
• MGIID: 1351650
• Length: 913
• Species: Mus musculus
• Alignment Length: 963
• Identity: 316/964 (33%)
• Similarity: 474/964 (49%)
• Gaps: 164/964 (17%)

  Fly   237 RFKKGDR---TTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQV 298
            ||:..|.   |.||.||..:.:.|..|||||||||.|.   |:|  |:.||||:.|||||.||:.
Mouse     4 RFQVADMEELTIWEQHTATLYKDPRRGFGIAVSGGHDR---ASG--SVVVSDVVPGGPAEGRLRT 63

  Fly   299 NDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVK--RRVPLNPINAAGAVQHQHS------HS 355
            .|.|:.|||||:|||..|.|:|:|:....|..:.||  |||.|....|:.|..||.|      |.
Mouse    64 GDHIVMVNGVSVENVTSAFAIQILKTCTKTANVTVKRPRRVQLPATKASPASGHQLSDQEEADHG 128

  Fly   356 LSSVGLMANGS----------------------------GGVAPTPITSLSQPNSLN-----SSL 387
            ....|..::||                            ||         |:.|.|:     ..|
Mouse   129 RGYEGDSSSGSGRSWGERSRRSRAGRRGRVGSHGRRSSGGG---------SEANGLDLVSGYKRL 184

  Fly   388 VQNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNC 452
            .:.....:|:|..|.|....:::||.||.::|:|.|:...   |.|..:.|||||:|.:|:..:.
Mouse   185 PKQDVLMRPLKSVLVKRRNSEEFGVKLGSQIFIKHITESG---LAARNHGLQEGDLILQINGVSS 246

  Fly   453 GDTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSS 517
            .: :||.:.:::|:..:..|.|:||||                    ||.......|.||  .|.
Mouse   247 AN-LSLSDTRRLIEKSEGELTLLVLRD--------------------SGQFLVNIPPAVS--DSD 288

  Fly   518 NNNLEDPYLPGGASYSSQNLYVQPPTRTSNGPNINGNGLNDEKSNL---TPRGRSRGPIMDGVSL 579
            ::.:||      .|..:..|...||:.....|........|.:::.   ||:.|.|
Mouse   289 SSLMED------ISDLTSELSQAPPSHVPPPPLKGQRSPEDSQTDSPVETPQPRRR--------- 338

  Fly   580 QQLDRPVTPTRGRSAAIDEPPRPPPPRGSSGGAAQEDFY--SSRRQLYEERQSAEPRFISFQKEG 642
               :|.|     .|.||.||..|        |.::.|.|  .||:.|.:...|.:.|.:||.|..
Mouse   339 ---ERSV-----NSRAIAEPESP--------GESRYDIYRVPSRQSLEDRGYSPDTRVVSFPKGA 387

  Fly   643 SVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQ--DRI 705
            |:|:||.|||:.||||:.||.||||..||:..||:||:||.|....:||||||.|||.|.  :.:
Mouse   388 SIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDEILQVNGMPFRNLTREEAVQFLLGLPPGEDM 452

  Fly   706 DLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCD-NPSKGEMAFKAGDVFRVIDTL---------HN 760
            :|:.|..::.:.::|.::.||||:|:|||..: :|..| :.|..||||.|:|||         |:
Mouse   453 ELVTQSKQDIFKKMVQSRVGDSFYIRTHFELEPSPPYG-LGFTRGDVFHVVDTLYPGSGPGHGHS 516

  Fly   761 GVVGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMN-------ANESRGNFFR--- 815
            ...|.|...::||..:|.:||||||:||||:||:.:  |.::...       .:..|..|:|
Mouse   517 SHGGLWLAARMGRDLREQERGVIPNQSRAEQLASLE--AAQRAAGVGPGASVGSNPRAEFWRLRG 579

  Fly   816 RRRSTHRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFP 880
            .||.|.:.|...|||   |:........:|.|||||||...|.||||:.|||:|:|.::|..:.|
Mouse   580 LRRGTKKASTQRSRE---DLSALTRQGHYPPYERVVLREASFKRPVVILGPVADIAMKKLTTEMP 641

  Fly   881 DKFSTPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTD 945
            ::|...    :..:.|....:|::|..:|.:.:|.||||||:||:|::||||.|:||:|||...:
Mouse   642 EEFEIA----ESMSRTDSPSKIIKLDTVRVIAERDKHALLDVTPSAIERLNYVQYYPIVIFCAPE 702

  Fly   946 SKHVIKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIAL-SDEESWYRKLRDSIDLQQSG 1009
            |:..:|.||..|..|:.:||::|..|.|||::...|:|:..|.| ...:|||::::..|..||:.
Mouse   703 SRPALKALREWLAPASRRSSRRLYAQAQKLQKHSGHLFTATIPLHGTSDSWYQEVKAVIQQQQAR 767

  Fly  1010 AVWMSESKPVESLSDDFLFP-----MTTSRLSYASSPESDLELSPGPSASLSLGNLPQLVKASSD 1069
            .:|.:|.: :.|.|:|...|     .::..||..|...||.|.:.|..|.......||.|.....
Mouse   768 PIWTAEDQ-LNSSSEDLDLPGHGLAASSGDLSCDSRTNSDYEDTDGEGAYTDREGGPQDVDEEVA 831

  Fly  1070 PSIATNQDN---LDRDRDIIGEG--LPPPYTVPYDHAVPANPNRRQTMDSSKY 1117
            |:.......   :|..:.::|.|  :...:....|.....:..|:.:|.:.|:
Mouse   832 PTALARSSEPVWVDDHQGLMGHGTTITDKWETQADSHYTQDQRRQDSMRTYKH 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	43/85 (51%)
		PDZ_signaling	396..477	CDD:238492	26/81 (32%)
		PDZ_signaling	633..710	CDD:238492	41/79 (52%)
		SH3_ZO	729..790	CDD:212793	30/71 (42%)
		GuKc	831..1007	CDD:214504	68/177 (38%)
		ZU5	2263..2351	CDD:279170
Tjp3	NP_001269025.1	PDZ_signaling	19..99	CDD:238492	43/85 (51%)
		PDZ_signaling	194..270	CDD:238492	25/80 (31%)
		PDZ_signaling	378..443	CDD:238492	37/65 (57%)
		SH3	473..546	CDD:302595	33/74 (45%)
		GuKc	589..765	CDD:214504	71/183 (39%)
		Guanylate_kin	620..764	CDD:279019	57/148 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C115544735
eggNOG	1	0.900				E1_KOG3580
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950		0	Normalized mean entropy	S6759
OMA	1	1.010
OrthoDB	1	1.010				D1175136at2759
OrthoFinder	1	1.000				FOG0001893
OrthoInspector	1	1.000				T615128
orthoMCL	1	0.900				OOG5_129845
Panther	1	1.100			LDO	PTHR13865
Phylome	1	0.910		0.800	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R3326
TreeFam	0	0.000	Not matched by this tool.
	11	10.740