DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pyd and TJP3

DIOPT Version :10

Sequence 1:NP_001246998.1 Gene:pyd / 41062 FlyBaseID:FBgn0262614 Length:2395 Species:Drosophila melanogaster
Sequence 2:XP_047294567.1 Gene:TJP3 / 27134 HGNCID:11829 Length:985 Species:Homo sapiens


Alignment Length:938 Identity:300/938 - (31%)
Similarity:450/938 - (47%) Gaps:180/938 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   244 TTWEYHTVAVTRVPGYGFGIAVSGGRDNPHFANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGV 308
            |.||.||..:::.|..|||||:|||||.|     ..|:.||||:.|||||.|||..|.|:.||||
Human    71 TIWEQHTATLSKDPRRGFGIAISGGRDRP-----GGSMVVSDVVPGGPAEGRLQTGDHIVMVNGV 130

  Fly   309 SLENVEYATAVQVLRDSGNTVQLVVK--RRVPLNPINAA-------------------------- 345
            |:||...|.|:|:|:.......:.||  ||:.|....|:                          
Human   131 SMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRG 195

  Fly   346 ----------------------GAVQHQHSHSLSSVGLMANGSGGVAPTPITSLSQPNSLNSSLV 388
                                  |......||...|.|      ||.....:..:|....|....|
Human   196 YDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPG------GGSEANGLALVSGFKRLPRQDV 254

  Fly   389 QNASSGQPIKVTLTKGGKKDDYGVVLGCRLFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCG 453
            |.    :|:|..|.|....:::||.||.::|:|.|:...   |.|....|||||:|.:|:..: .
Human   255 QM----KPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSG---LAARHRGLQEGDLILQINGVS-S 311

  Fly   454 DTMSLKEAKKIIDGCKERLNLVVLRDITNQTAVSQLNLNNSASHQASGNIYATHQPQVSGCSSSN 518
            ..:||.:.:::|:..:.:|:|:||||                    .|.......|.||  .|.:
Human   312 QNLSLNDTRRLIEKSEGKLSLLVLRD--------------------RGQFLVNIPPAVS--DSDS 354

  Fly   519 NNLEDPYLPGGASYSSQ--NLYVQPPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQ 581
            :.|||  :...||..||  ..::.||                      ||...|.|     ...|
Human   355 SPLED--ISDLASELSQAPPSHIPPP----------------------PRHAQRSP-----EASQ 390

  Fly   582 LDRPVTPTRGR------SAAIDEP--PRPPPPRGSSGGAAQEDFY--SSRRQLYEERQSAEPRFI 636
            .|.||...|.|      |..|.||  .|...||.||     .|.|  .|.:.:.:...|.:.|.:
Human   391 TDSPVESPRLRRESSVDSRTISEPDEQRSELPRESS-----YDIYRVPSSQSMEDRGYSPDTRVV 450

  Fly   637 SFQKEGSVGIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSL 701
            .|.|..|:|:||.|||:.||||:.||.||||..||:..||:||:|||:....:||||||.|||.|
Human   451 RFLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGL 515

  Fly   702 Q--DRIDLIVQYCKEEYDEVVTNQRGDSFHIKTHFHCDNPSKGEMAFKAGDVFRVIDTLHNGV-- 762
            .  :.::|:.|..::.:.::|.::.||||:|:|||..:......:.|..||||.|:||||.|.  
Human   516 PPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQ 580

  Fly   763 ----VGSWQVLKIGRGHQEMQRGVIPNKSRAEELATAQFNATKKEMNANESRGN----FFRRRRS 819
                .|.|..:::||..:|.:||:|||:||||:||:.:.......:....|.|:    .|.|.|.
Human   581 SHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRG 645

  Fly   820 THRRSKSLSRENWDDVVFSDSISKFPAYERVVLRHPGFVRPVVLFGPVSDLARERLAKDFPDKFS 884
            ..|.:|..::.:.:|:.......::|.|||||||...|.||||:.|||:|:|.::|..:.||:|.
Human   646 LRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFE 710

  Fly   885 TPLQDDDKSAATSGKCRIVRLSNIRDVMDRGKHALLDITPNAVDRLNYAQFYPVVIFLKTDSKHV 949
            ..    :..:.|....:|::|..:|.:.::.||||||:||:|::||||.|:||:|:|...:|:..
Human   711 IA----ETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPA 771

  Fly   950 IKQLRHGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIALS-DEESWYRKLRDSIDLQQSGAVWM 1013
            :|.||..|..|:.:|:::|..|.|||.:..||:|:..|.|: ..::||::|:..|..||:..:|.
Human   772 LKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWT 836

  Fly  1014 SESKPVESLSDDFLFPM-----TTSRLSYASSPESDLELSPGPSASLSLGN-------------- 1059
            :|.:...||.|:...|.     :::.||..|...||.| :.|...:.:.|.              
Human   837 AEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDYE-TDGEGGAYTDGEGYTDGEGGPYTDVD 900

  Fly  1060 ----LPQLVKASSDPSIATNQDNLDRDR 1083
                .|.|.: ||:| :..::....|||
Human   901 DEPPAPALAR-SSEP-VQADESQSPRDR 926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pydNP_001246998.1 PDZ1_ZO1-like 249..335 CDD:467209 42/87 (48%)
PDZ2_ZO1-like_ds 397..479 CDD:467210 26/81 (32%)
PDZ3_ZO1-like_domain 632..711 CDD:467211 40/80 (50%)
SH3_ZO 729..790 CDD:212793 27/66 (41%)
GuKc 831..1007 CDD:214504 66/176 (38%)
ZU5 2264..2365 CDD:459941
TJP3XP_047294567.1 PDZ1_ZO1-like 76..157 CDD:467209 41/85 (48%)
PDZ2_ZO1-like_ds 259..337 CDD:467210 26/81 (32%)
PDZ3_ZO1-like_domain 446..527 CDD:467211 40/80 (50%)
SH3_ZO-3 542..612 CDD:212961 30/69 (43%)
GuKc 654..830 CDD:214504 66/179 (37%)
Blue background indicates that the domain is not in the aligned region.

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