Protein Alignment Ir85a and Grik1

DIOPT Version :10

• Sequence 1: NP_649833.1
• Gene: Ir85a / 41052
• FlyBaseID: FBgn0037630
• Length: 605
• Species: Drosophila melanogaster
• Sequence 2: NP_001104587.1
• Gene: Grik1 / 29559
• RGDID: 2732
• Length: 949
• Species: Rattus norvegicus
• Alignment Length: 736
• Identity: 133/736 - (18%)
• Similarity: 231/736 - (31%)
• Gaps: 261/736 - (35%)

  Fly    27 PL--DLKKSSIVMVKMSQILCKARIKVLFVYFENQTSHEHTGQILKEV--------------TKC 75
            ||  ::|||                |..:|.|:  .|||...:|||::              |..
  Rat   214 PLLKEMKKS----------------KEFYVIFD--CSHETAAEILKQILFMGMMTEYYHYFFTTL 260

  Fly    76 DISNQNTPLEAVKDDGILMYMVMITTNISQPLELSLIRKKS----AAKHRSHVFLL----VRDAD 132
            |:...:  ||..:..|:.|....: .||..|...|:|.|.|    .|..|....||    ..:|.
  Rat   261 DLFALD--LELYRYSGVNMTGFRL-LNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAA 322

  Fly   133 TVSDAWMRASFRQFWKIWLLNIVILYWRDGR-----LNAYRYNP------FMDNYLIPVDNKP-- 184
            .:.||             :..:.|...|..:     |..:|:.|      ||:  ||......
  Rat   323 LMYDA-------------VYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMN--LIKEARWDGL 372

  Fly   185 ------NEVPTLEQLFPKTIPNMQRKPLRMC-------IYKDDVRAIFWRQGTILG-TDG----- 230
                  |:...|.:.|...|.:::.:.....       :||...:...|...:.|. |||
  Rat   373 TGRITFNKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNRDRS 437

  Fly   231 --LLAAYVAERLNATMMITRPH---------SYNNHNLSSDICFLEVAKEYVDVAMNIRF----- 279
              :..:.....|..|.::..|:         .|.|..... .| |::.||..::   :.|
  Rat   438 NNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEG-YC-LDLLKELSNI---LGFLYDVK 497

  Fly   280 LVPD----------TFRKQAESTVSHTRDDLCV-----------IVPKAK--------------- 308
            ||||          .:....:..:.| |.||.|           ::..:|
  Rat   498 LVPDGKYGAQNDKGEWNGMVKELIDH-RADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPN 561

  Fly   309 -TAPTFWNIFRSFGSLVWALILVSVLVANVFCYIL----------------KSEVGRVPMQLF-- 354
             |.|..::........:|..:|::.|..:...:::                .|:|......|.
  Rat   562 GTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNS 626

  Fly   355 ----AGALTMPMTQIPPNH-SIRLFLIFWLYFGLLICSAFKGNLTSMMVFQPYLPDINQLGALAR 414
                .|||....:::.|.. |.|:....|.:|.|:|.|::..||.:.:..:.....|:....||:
  Rat   627 FWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAK 691

  Fly   415 SHYHIIIRPRHVKHIQH-------FLTLGHKHESRIREQMLE-VSDTQMYEMMRNND--IRFAYL 469
            .           ..|::       .:|...|.:....|:|.. :|..|...:::|:|  |:....
  Rat   692 Q-----------TKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLT 745

  Fly   470 EKYHIARFQVNSRVHMHLGRPLFHLMNSCLVPF------HAVYI------------VPYGSPYLG 516
            ..|.:                   ||.|..:.:      :...|            .|.||||..
  Rat   746 TDYAL-------------------LMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRD 791

  Fly   517 FLDSLIRSSHEFG-----FERYWDRIMNSAFIKSGVKVVNRRRGSG-----NDEPVVLKLQHFHA 571
            .:...|....|.|     .|::|                   ||:|     :.|...|.:::...
  Rat   792 KITIAILQLQEEGKLHMMKEKWW-------------------RGNGCPEEDSKEASALGVENIGG 837

  Fly   572 VFALWLVGIGMACIVLAWEHL 592
            :|.:...|:.::..|...|.|
  Rat   838 IFIVLAAGLVLSVFVAIGEFL 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir85a	NP_649833.1	None
Grik1	NP_001104587.1	PBP1_iGluR_Kainate	38..431	CDD:380605	51/252 (20%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	69/423 (16%)